The position of the fast-inactivation gate during lidocaine block of voltage-gated Na+ channels
about
High-affinity blockade of voltage-operated skeletal muscle and neuronal sodium channels by halogenated propofol analoguesMexiletine block of disease-associated mutations in S6 segments of the human skeletal muscle Na(+) channelFast- or slow-inactivated state preference of Na+ channel inhibitors: a simulation and experimental studyModulation of sodium channel inactivation gating by a novel lactam: implications for seizure suppression in chronic limbic epilepsyA pharmacophore derived phenytoin analogue with increased affinity for slow inactivated sodium channels exhibits a desired anticonvulsant profileIsoform-specific lidocaine block of sodium channels explained by differences in gatingRapid and slow voltage-dependent conformational changes in segment IVS6 of voltage-gated Na(+) channelsResidues in Na(+) channel D3-S6 segment modulate both batrachotoxin and local anesthetic affinities.Molecular mechanism of allosteric modification of voltage-dependent sodium channels by local anestheticsA revised view of cardiac sodium channel "blockade" in the long-QT syndromeMolecular determinants of state-dependent block of voltage-gated sodium channels by pilsicainide.Mechanisms of anesthesia: towards integrating network, cellular, and molecular level modeling.Sodium channel inactivation: molecular determinants and modulation.Molecular action of lidocaine on the voltage sensors of sodium channelsA structural rearrangement in the sodium channel pore linked to slow inactivation and use dependence.Block of inactivation-deficient Na+ channels by local anesthetics in stably transfected mammalian cells: evidence for drug binding along the activation pathway.State-dependent block of wild-type and inactivation-deficient Na+ channels by flecainide.Antagonism of lidocaine inhibition by open-channel blockers that generate resurgent Na current.Local anesthetics disrupt energetic coupling between the voltage-sensing segments of a sodium channel.Using lidocaine and benzocaine to link sodium channel molecular conformations to state-dependent antiarrhythmic drug affinity.Isoflurane inhibits the tetrodotoxin-resistant voltage-gated sodium channel Nav1.8.Block of human cardiac sodium channels by lacosamide: evidence for slow drug binding along the activation pathway.Advances in targeting voltage-gated sodium channels with small molecules.Lidocaine reduces the transition to slow inactivation in Na(v)1.7 voltage-gated sodium channels.The sodium channel as a target for local anesthetic drugs.Functional Interactions between Distinct Sodium Channel Cytoplasmic Domains through the Action of Calmodulin.Outward stabilization of the S4 segments in domains III and IV enhances lidocaine block of sodium channels.Block of wild-type and inactivation-deficient cardiac sodium channels IFM/QQQ stably expressed in mammalian cells.Flecainide sensitivity of a Na channel long QT mutation shows an open-channel blocking mechanism for use-dependent block.An improved model for the binding of lidocaine and structurally related local anaesthetics to fast-inactivated voltage-operated sodium channels, showing evidence of cooperativityVoltage-dependent blockade of normal and mutant muscle sodium channels by benzylalcohol.Lidocaine induces a slow inactivated state in rat skeletal muscle sodium channels.Bupivacaine blocks N-type inactivating Kv channels in the open state: no allosteric effect on inactivation kinetics.Commentary: A revised view of local anesthetic action: what channel state is really stabilized?Cocaine binds to a common site on open and inactivated human heart (Na(v)1.5) sodium channels.Selective block of late Na(+) current by local anaesthetics in rat large sensory neurones.The selectivity filter of the voltage-gated sodium channel is involved in channel activation.The conformation and movement of Na channel inactivation gate peptide in linker between domain III and IV during inactivation by NMR spectroscopy and molecular modeling study.Compound-specific Na+ channel pore conformational changes induced by local anaesthetics.Mechanisms of Drug Binding to Voltage-Gated Sodium Channels.
P2860
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P2860
The position of the fast-inactivation gate during lidocaine block of voltage-gated Na+ channels
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
The position of the fast-inact ...... of voltage-gated Na+ channels
@ast
The position of the fast-inact ...... of voltage-gated Na+ channels
@en
type
label
The position of the fast-inact ...... of voltage-gated Na+ channels
@ast
The position of the fast-inact ...... of voltage-gated Na+ channels
@en
prefLabel
The position of the fast-inact ...... of voltage-gated Na+ channels
@ast
The position of the fast-inact ...... of voltage-gated Na+ channels
@en
P2860
P356
P1476
The position of the fast-inact ...... of voltage-gated Na+ channels
@en
P2093
S C Cannon
V Vedantham
P2860
P356
10.1085/JGP.113.1.7
P577
1999-01-01T00:00:00Z