Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake - Wikidata - awgldk - TriplyDB

Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake

Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake

http://www.wikidata.org/entity/Q35059247

about

High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice Parkinson's disease: animal models and dopaminergic cell vulnerability Transgenic LRRK2 (R1441G) rats-a model for Parkinson disease?Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration Cognitive dysfunction and depression in Parkinson's disease: what can be learned from rodent models?Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging.LRRK2 affects vesicle trafficking, neurotransmitter extracellular level and membrane receptor localization.Selective expression of Parkinson's disease-related Leucine-rich repeat kinase 2 G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression.Small molecule kinase inhibitors for LRRK2 and their application to Parkinson's disease models.The I2020T Leucine-rich repeat kinase 2 transgenic mouse exhibits impaired locomotive ability accompanied by dopaminergic neuron abnormalities Expression of human E46K-mutated α-synuclein in BAC-transgenic rats replicates early-stage Parkinson's disease features and enhances vulnerability to mitochondrial impairment.LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function Human dopamine transporter gene: differential regulation of 18-kb haplotypes The function of orthologues of the human Parkinson's disease gene LRRK2 across species: implications for disease modelling in preclinical research.Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice.Leucine-rich repeat kinase 2 (LRRK2) cellular biology: a review of recent advances in identifying physiological substrates and cellular functions.Insights into LRRK2 function and dysfunction from transgenic and knockout rodent models.LRRK2 and vesicle trafficking.LRRK2, a puzzling protein: insights into Parkinson's disease pathogenesis Cellular processes associated with LRRK2 function and dysfunction Models of LRRK2-Associated Parkinson's Disease.Genetic rat models of Parkinson's disease.LRRK2 R1441G mice are more liable to dopamine depletion and locomotor inactivity.Targeted kinase inhibition relieves slowness and tremor in a Drosophila model of LRRK2 Parkinson's disease.New developments in genetic rat models of Parkinson's disease.Dopamine D2 receptor-mediated neuroprotection in a G2019S Lrrk2 genetic model of Parkinson's disease.

P2860

Q27303568-215C7DEE-026D-4DAC-97C6-19B47CA0BCC2 Q27308060-504D79A4-52C2-422C-A291-36E86077BCA1 Q28080503-6A06CC0E-D500-4316-AA26-EEF79600B601 Q30410927-2DD07BC4-2C25-4B9F-A3F4-F614FA8C25D1 Q30653185-88372F26-59D6-48AB-B072-B37E0A871EB7 Q34307633-F98E9705-84AB-484F-BD34-FE5385E2E4B6 Q34325540-DF7D13A4-7EE0-4469-A9C6-FAF647A0C955 Q35027709-A18814F7-4B3F-448E-AB49-4AFAAF035A84 Q35999331-89CC8A0E-9FB0-457C-A83F-B55B24384A5A Q36015579-2FA9737F-E068-4E87-A7DD-2380513290F0 Q36305967-ED54B371-1094-42BD-859A-872C878827CC Q36553302-65065FB7-FD75-4250-B2F9-346E6A1CCDAB Q36581417-6A2CB0E6-FB71-46A0-98F4-7A2DFAB19657 Q37408178-476DE36E-56FF-42E7-934D-B8A385F245AF Q37513500-4A47E9EE-6BB6-45BD-B8AF-08AABC85CA27 Q37701053-13A17073-C35A-4AB0-AFB9-03AED663793B Q37955275-CC3659A3-408B-435A-BA46-21AF3DDE42D7 Q38044434-23E2D8BB-75C0-4E8A-A849-FCDF43A33AA7 Q38044441-5582F82E-ADD7-414E-ABF8-813FE041BF90 Q38218398-3159ACFB-2015-41CF-9B29-D86BD57A9FBB Q38433725-BB19B63A-3E72-492B-A54E-2BA59B784080 Q39206443-1525C623-3D45-4A43-BF04-E4DEBAC8E7D6 Q42542683-C82DF0E0-855C-4A63-82BD-02F6A232F0D2 Q42927984-2840C720-EB3F-47EC-9058-AEE2FDCB162C Q48163602-28A5782E-BD10-4DE3-B28D-2E51D975F9C5 Q48502440-F1F3F501-8658-4365-9ECC-2735A380FC3D Q50055669-5121AB01-E0C3-4256-A025-66FAD4BB7CEE

P2860

Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake

http://www.wikidata.org/entity/Q35059247

description

2011 nî lūn-bûn

@nan

2011 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年学术文章

@wuu

2011年学术文章

@zh-cn

2011年学术文章

@zh-hans

2011年学术文章

@zh-my

2011年学术文章

@zh-sg

2011年學術文章

@yue

name

Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake

@ast

Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake

@en

type

label

Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake

@ast

Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake

@en

prefLabel

Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake

@ast

Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake

@en

P1433

Q35059247-8095921D-8B74-4B12-8439-F9266C99B758

P1476

Q35059247-4A8DB271-A42A-46E7-AD7C-E4C2CADB6E47

P2093

Q35059247-006A7F20-0D04-4A16-BFCC-99FAB52771F8

Q35059247-0A677E7F-F71B-4E39-9B7B-F5F3E2517BB0

Q35059247-0EEDCB8D-6510-4D8E-8633-4834DA5CF5E4

Q35059247-616A182C-39B0-4443-A299-91C95849BEC7

Q35059247-F8D3BAA0-BCCE-4D84-9B61-23B539A73A7F

P2860

Q35059247-04FEB019-41B2-4AB9-BAC3-89F3755CA505

Q35059247-099E1247-AF7A-4313-B9B6-C3F3DC15E932

Q35059247-13AB329D-A84D-43B7-BDD9-40700F37F582

Q35059247-1483E4FA-6946-4670-BE03-D98075886591

Q35059247-14FF7275-A25F-4E60-9628-C627A8D50A4D

Q35059247-158BD28D-C32C-421B-A9BC-79B15CA88247

Q35059247-1752B641-EAAC-405D-A243-AF1F7B731B3B

Q35059247-20FB2118-25C7-4CFE-A4EC-1F86B79C9A40

Q35059247-22305D35-E3BA-479A-9D89-1EF06DC0AB4D

Q35059247-2449FEF1-5B50-4BC1-BC3B-F3858852FA40

P304

Q35059247-0972461B-E0BB-46CE-B295-51A2C7F767D4

P31

Q35059247-BE070099-468F-4137-94CF-FD3C50EA5778

P356

Q35059247-A7587053-34E2-4FC8-8C3E-4DB4E4306C82

P407

Q35059247-13F1AD2F-2E54-46F6-9284-6B4A10D38B56

P433

Q35059247-1A1834CE-1DAC-4992-B479-6B39488743BA

P478

Q35059247-6E398316-E123-45D7-B318-BAFC14C89395

P50

Q35059247-04B1D1BB-D915-4369-83C4-063631ADA55C

P577

Q35059247-0F8D0617-7A5D-456C-82D0-3A1CD96FA260

P698

Q35059247-4DF9F911-89DD-446A-809E-8B4F95441012

P921

Q35059247-57df9742-3a36-4b19-b3a4-2f5ab1d8aa92

P932

Q35059247-574B8FB6-C282-4D96-B0AC-24C6C35043B9

P356

P1433

International Journal of Biological Sciences

P1476

Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake

@en

P2093

Hongxia Zhou

http://www.w3.org/2001/XMLSchema#string

Jianbin Tong

http://www.w3.org/2001/XMLSchema#string

Weimin C Hong

http://www.w3.org/2001/XMLSchema#string

Xu-Gang Xia

http://www.w3.org/2001/XMLSchema#string

Yong-Jian Liu

http://www.w3.org/2001/XMLSchema#string

P2860

Genome sequence of the Brown Norway rat yields insights into mammalian evolution

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice

The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

Kinase activity of mutant LRRK2 mediates neuronal toxicity

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

P304

753-761

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.7150/IJBS.7.753

http://www.w3.org/2001/XMLSchema#string

P407

P433

6

http://www.w3.org/2001/XMLSchema#string

P478

7

http://www.w3.org/2001/XMLSchema#string

P50

P577

2011-06-09T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

21698001

http://www.w3.org/2001/XMLSchema#string

P921

P932

3119847

http://www.w3.org/2001/XMLSchema#string