about
The notch regulator MAML1 interacts with p53 and functions as a coactivatorRegulation of ploidy and senescence by the AMPK-related kinase NUAK1Vitamin D3 up-regulated protein 1(VDUP1) is regulated by FOXO3A and miR-17-5p at the transcriptional and post-transcriptional levels, respectively, in senescent fibroblastsMel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cellsThe HBP1 transcriptional repressor participates in RAS-induced premature senescenceThe Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cellsMel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteinsStem cells, senescence, neosis and self-renewal in cancer.Redox control of senescence and age-related diseaseAromatase Inhibitor-Mediated Downregulation of INrf2 (Keap1) Leads to Increased Nrf2 and Resistance in Breast CancerSilencing of the Menkes copper-transporting ATPase (Atp7a) gene increases cyclin D1 protein expression and impairs proliferation of rat intestinal epithelial (IEC-6) cells.Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressorHuman RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges.A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen.Role of senescence and mitotic catastrophe in cancer therapy.Tumor suppression by p53: making cells senescent.BMI1 and Mel-18 oppositely regulate carcinogenesis and progression of gastric cancer.DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretionExpression of BMI-1 and Mel-18 in breast tissue--a diagnostic marker in patients with breast cancerExtracellular cystatin SN and cathepsin B prevent cellular senescence by inhibiting abnormal glycogen accumulation.ARF-induced downregulation of Mip130/LIN-9 protein levels mediates a positive feedback that leads to increased expression of p16Ink4a and p19Arf.Cellular senescence: a link between cancer and age-related degenerative disease?microRNA-141 regulates BMI1 expression and induces senescence in human diploid fibroblasts.Oncogenic role of the chromobox protein CBX7 in gastric cancer.Cancer and schizophrenia: is there a paradox?The polycomb group protein BMI1 is a transcriptional target of HDAC inhibitors.Reprogramming of replicative senescence in hepatocellular carcinoma-derived cells.RNAi-mediated silencing of the Bmi-1 gene causes growth inhibition and enhances doxorubicin-induced apoptosis in MCF-7 cells.Epimorphic regeneration in mice is p53-independentArsenite induces premature senescence via p53/p21 pathway as a result of DNA damage in human malignant glioblastoma cells.Inhibition of Mdm2 sensitizes human retinal pigment epithelial cells to apoptosis.PLK1 inhibition down-regulates polycomb group protein BMI1 via modulation of the miR-200c/141 cluster.βTrCP regulates BMI1 protein turnover via ubiquitination and degradation.Reversing the aging stromal phenotype prevents carcinoma initiationCyclin D1 determines mitochondrial function in vivo.Chemotherapeutic approaches for targeting cell death pathways.PML-nuclear bodies decrease with age and their stress response is impaired in aged individuals.MicroRNA-31 is a transcriptional target of histone deacetylase inhibitors and a regulator of cellular senescenceBioengineering embryonic stem cell microenvironments for the study of breast cancerMYCN and MYC regulate tumor proliferation and tumorigenesis directly through BMI1 in human neuroblastomas.
P2860
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P2860
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
What has senescence got to do with cancer?
@ast
What has senescence got to do with cancer?
@en
type
label
What has senescence got to do with cancer?
@ast
What has senescence got to do with cancer?
@en
prefLabel
What has senescence got to do with cancer?
@ast
What has senescence got to do with cancer?
@en
P2860
P1433
P1476
What has senescence got to do with cancer?
@en
P2093
Goberdhan P Dimri
P2860
P304
P356
10.1016/J.CCR.2005.05.025
P577
2005-06-01T00:00:00Z