Membrane-targeting potentiates guanine nucleotide exchange factor CDC25 and SOS1 activation of Ras transforming activity.
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M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase RalMembrane-associated guanylate kinase with inverted orientation (MAGI)-1/brain angiogenesis inhibitor 1-associated protein (BAP1) as a scaffolding molecule for Rap small G protein GDP/GTP exchange protein at tight junctionsThe phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptorDifferential interactions of human Sos1 and Sos2 with Grb2Regulation of Sos activity by intramolecular interactions.CDC42 and FGD1 cause distinct signaling and transforming activities.N terminus of Sos1 Ras exchange factor: critical roles for the Dbl and pleckstrin homology domainsPhosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2Tight association of GRB2 with receptor protein-tyrosine phosphatase alpha is mediated by the SH2 and C-terminal SH3 domainsThe endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brainDOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membraneL-selectin activates the Ras pathway via the tyrosine kinase p56lckThe localization of bullous pemphigoid antigen 180 (BP180) in hemidesmosomes is mediated by its cytoplasmic domain and seems to be regulated by the beta4 integrin subunitInteractions of nucleotide release factor Dss4p with Sec4p in the post-Golgi secretory pathway of yeast.Stimulation of Ras guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) upon tyrosine phosphorylation by the Cdc42-regulated kinase ACK1Interactions between Src homology (SH) 2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factorThe role of the PH domain in the signal-dependent membrane targeting of Sos.The proto-oncogene product c-Cbl becomes tyrosine phosphorylated by stimulation with GM-CSF or Epo and constitutively binds to the SH3 domain of Grb2/Ash in human hematopoietic cellsLck regulates Vav activation of members of the Rho family of GTPasesSyk-dependent phosphorylation of Shc. A potential link between FcepsilonRI and the Ras/mitogen-activated protein kinase signaling pathway through SOS and Grb2Insulin-stimulated disassociation of the SOS-Grb2 complexThe isoform-specific stretch of hSos1 defines a new Grb2-binding domain.Intersectin can regulate the Ras/MAP kinase pathway independent of its role in endocytosis.Evidence that DOCK180 up-regulates signals from the CrkII-p130(Cas) complex.Ras history: The saga continues.Signal transduction in T lymphocytes using a conditional allele of SosPhysical modulation of intracellular signaling processes by locational regulation.A novel interaction of CLN3 with nonmuscle myosin-IIB and defects in cell motility of Cln3(-/-) cellsTargeting mutant KRAS for anticancer therapeutics: a review of novel small molecule modulators.Requirements of multiple domains of SLI-1, a Caenorhabditis elegans homologue of c-Cbl, and an inhibitory tyrosine in LET-23 in regulating vulval differentiation.Rac regulates cardiovascular superoxide through diverse molecular interactions: more than a binary GTP switch.Insulin stimulation of a MEK-dependent but ERK-independent SOS protein kinaseTC21 causes transformation by Raf-independent signaling pathways.The Ras-specific exchange factors mouse Sos1 (mSos1) and mSos2 are regulated differently: mSos2 contains ubiquitination signals absent in mSos1The 66-kDa Shc isoform is a negative regulator of the epidermal growth factor-stimulated mitogen-activated protein kinase pathway.Catalytic activity of the mouse guanine nucleotide exchanger mSOS is activated by Fyn tyrosine protein kinase and the T-cell antigen receptor in T cellsShc isoform-specific tyrosine phosphorylation by the insulin and epidermal growth factor receptors.Activation of the Drosophila C3G leads to cell fate changes and overproliferation during development, mediated by the RAS-MAPK pathway and RAP1.Activation of cJUN N-terminal kinase by herpes simplex virus type 1 enhances viral replication.
P2860
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P2860
Membrane-targeting potentiates guanine nucleotide exchange factor CDC25 and SOS1 activation of Ras transforming activity.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Membrane-targeting potentiates ...... of Ras transforming activity.
@ast
Membrane-targeting potentiates ...... of Ras transforming activity.
@en
type
label
Membrane-targeting potentiates ...... of Ras transforming activity.
@ast
Membrane-targeting potentiates ...... of Ras transforming activity.
@en
prefLabel
Membrane-targeting potentiates ...... of Ras transforming activity.
@ast
Membrane-targeting potentiates ...... of Ras transforming activity.
@en
P2093
P2860
P356
P1476
Membrane-targeting potentiates ...... of Ras transforming activity.
@en
P2093
L A Quilliam
P2860
P304
P356
10.1073/PNAS.91.18.8512
P407
P577
1994-08-01T00:00:00Z