Small temperature dependence of the kinetic isotope effect for the hydride transfer reaction catalyzed by Escherichia coli dihydrofolate reductase.
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The importance of ensemble averaging in enzyme kineticsChemical Ligation and Isotope Labeling to Locate Dynamic Effects during Catalysis by Dihydrofolate ReductaseLinking protein structure and dynamics to catalysis: the role of hydrogen tunnelling.Effects of a distal mutation on active site chemistry.On the curvature in logarithmic plots of rate coefficients for chemical reactionsHow Accurate Are Transition States from Simulations of Enzymatic Reactions?Update 1 of: Tunneling and dynamics in enzymatic hydride transfer.Good vibrations in enzyme-catalysed reactions.Escherichia coli dihydrofolate reductase catalyzed proton and hydride transfers: temporal order and the roles of Asp27 and Tyr100.Theoretical analysis of the unusual temperature dependence of the kinetic isotope effect in quinol oxidation.Coordinated effects of distal mutations on environmentally coupled tunneling in dihydrofolate reductase.Isotope effects as probes for enzyme catalyzed hydrogen-transfer reactions.Dynamics and dissipation in enzyme catalysisPromoting motions in enzyme catalysis probed by pressure studies of kinetic isotope effectsMechanisms and free energies of enzymatic reactions.Nonperfect synchronization of reaction center rehybridization in the transition state of the hydride transfer catalyzed by dihydrofolate reductase.Multidimensional tunneling, recrossing, and the transmission coefficient for enzymatic reactionsTransition state theory for enzyme kinetics.Hydrogen tunnelling in enzyme-catalysed H-transfer reactions: flavoprotein and quinoprotein systems.Connecting protein conformational dynamics with catalytic function as illustrated in dihydrofolate reductase.Unraveling the role of protein dynamics in dihydrofolate reductase catalysisThe Effect of Protein Mass Modulation on Human Dihydrofolate Reductase.Atom Tunneling in Chemistry.Protein motions during catalysis by dihydrofolate reductases.Triple isotopic labeling and kinetic isotope effects: exposing H-transfer steps in enzymatic systems.Hydrogen donor-acceptor fluctuations from kinetic isotope effects: a phenomenological model.Examinations of the Chemical Step in Enzyme Catalysis.Tuning of the H-transfer coordinate in primitive versus well-evolved enzymes.Temperature dependence of the kinetic isotope effects in thymidylate synthase. A theoretical study.An Analysis of All the Relevant Facts and Arguments Indicates that Enzyme Catalysis Does Not Involve Large Contributions from Nuclear Tunneling.Thymidylate synthase catalyzed H-transfers: two chapters in one tale.Simulations of remote mutants of dihydrofolate reductase reveal the nature of a network of residues coupled to hydride transfer.Coupling of protein motions and hydrogen transfer during catalysis by Escherichia coli dihydrofolate reductase.H/D isotope effect in methyl torsional interaction of acetone as calculated by a multicomponent molecular orbital method.HD isotope effect of methyl internal rotation for acetaldehyde in ground state as calculated from a multicomponent molecular orbital method.Benchmarking Quantum Mechanics/Molecular Mechanics (QM/MM) Methods on the Thymidylate Synthase-Catalyzed Hydride Transfer.Enzymatic Kinetic Isotope Effects from Path-Integral Free Energy Perturbation Theory.Variational transition state theory: theoretical framework and recent developments.Protein motions and dynamic effects in enzyme catalysis.Effect of pH on hydride transfer by Escherichia coli dihydrofolate reductase.
P2860
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P2860
Small temperature dependence of the kinetic isotope effect for the hydride transfer reaction catalyzed by Escherichia coli dihydrofolate reductase.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Small temperature dependence o ...... coli dihydrofolate reductase.
@ast
Small temperature dependence o ...... coli dihydrofolate reductase.
@en
type
label
Small temperature dependence o ...... coli dihydrofolate reductase.
@ast
Small temperature dependence o ...... coli dihydrofolate reductase.
@en
prefLabel
Small temperature dependence o ...... coli dihydrofolate reductase.
@ast
Small temperature dependence o ...... coli dihydrofolate reductase.
@en
P2093
P2860
P356
P1476
Small temperature dependence o ...... coli dihydrofolate reductase.
@en
P2093
P2860
P304
P356
10.1021/JP051184C
P407
P577
2005-05-01T00:00:00Z