Role of the mu 1 protein in reovirus stability and capacity to cause chromium release from host cells.
about
Antimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cells.Structure of the reovirus outer capsid and dsRNA-binding protein sigma3 at 1.8 A resolution.Structure of the reovirus membrane-penetration protein, Mu1, in a complex with is protector protein, Sigma3Determinants of strain-specific differences in efficiency of reovirus entryRequirements for the formation of membrane pores by the reovirus myristoylated micro1N peptide.Reovirus mu1 structural rearrangements that mediate membrane penetrationIndependent regulation of reovirus membrane penetration and apoptosis by the mu1 phi domainMutant cells selected during persistent reovirus infection do not express mature cathepsin L and do not support reovirus disassembly.Adaptation of reovirus to growth in the presence of protease inhibitor E64 segregates with a mutation in the carboxy terminus of viral outer-capsid protein sigma3.A monoclonal antibody specific for reovirus outer-capsid protein sigma3 inhibits sigma1-mediated hemagglutination by steric hindrance.Reovirus infection activates JNK and the JNK-dependent transcription factor c-Jun.Virion disassembly is required for apoptosis induced by reovirus.A single mutation in the carboxy terminus of reovirus outer-capsid protein sigma 3 confers enhanced kinetics of sigma 3 proteolysis, resistance to inhibitors of viral disassembly, and alterations in sigma 3 structure.Reovirus sigma NS and mu NS proteins form cytoplasmic inclusion structures in the absence of viral infection.Mammalian reovirus, a nonfusogenic nonenveloped virus, forms size-selective pores in a model membrane.Reovirus receptors and pathogenesis.Monoclonal antibodies to reovirus sigma 1 and mu 1 proteins inhibit chromium release from mouse L cells.Linkage between reovirus-induced apoptosis and inhibition of cellular DNA synthesis: role of the S1 and M2 genes.Reovirus variants selected during persistent infections of L cells contain mutations in the viral S1 and S4 genes and are altered in viral disassemblyThermostabilizing mutations in reovirus outer-capsid protein mu1 selected by heat inactivation of infectious subvirion particles.Mutations in reovirus outer-capsid protein sigma3 selected during persistent infections of L cells confer resistance to protease inhibitor E64Thermolabilizing pseudoreversions in reovirus outer-capsid protein micro 1 rescue the entry defect conferred by a thermostabilizing mutation.From touchdown to transcription: the reovirus cell entry pathwayReovirus receptors, cell entry, and proapoptotic signaling.Conformational changes required for reovirus cell entry are sensitive to pH.The μ1 72-96 loop controls conformational transitions during reovirus cell entry.Reovirus virion-like particles obtained by recoating infectious subvirion particles with baculovirus-expressed sigma3 protein: an approach for analyzing sigma3 functions during virus entry.In vitro recoating of reovirus cores with baculovirus-expressed outer-capsid proteins mu1 and sigma3.Protease cleavage of reovirus capsid protein mu1/mu1C is blocked by alkyl sulfate detergents, yielding a new type of infectious subvirion particle.Thermostability of reovirus disassembly intermediates (ISVPs) correlates with genetic, biochemical, and thermodynamic properties of major surface protein mu1.Sites and determinants of early cleavages in the proteolytic processing pathway of reovirus surface protein sigma3.Antibodies to rotavirus outer capsid glycoprotein VP7 neutralize infectivity by inhibiting virion decapsidation.Addition of exogenous protease facilitates reovirus infection in many restrictive cells.Strategy for nonenveloped virus entry: a hydrophobic conformer of the reovirus membrane penetration protein micro 1 mediates membrane disruption.Disulfide bonding among micro 1 trimers in mammalian reovirus outer capsid: a late and reversible step in virion morphogenesis.Reovirus apoptosis and virulence are regulated by host cell membrane penetration efficiency.The reovirus μ1 340-343 loop controls entry related conformational changes.The delta region of outer-capsid protein micro 1 undergoes conformational change and release from reovirus particles during cell entry.Peptides released from reovirus outer capsid form membrane pores that recruit virus particles.JAM-A-independent, antibody-mediated uptake of reovirus into cells leads to apoptosis.
P2860
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P2860
Role of the mu 1 protein in reovirus stability and capacity to cause chromium release from host cells.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Role of the mu 1 protein in re ...... omium release from host cells.
@ast
Role of the mu 1 protein in re ...... omium release from host cells.
@en
type
label
Role of the mu 1 protein in re ...... omium release from host cells.
@ast
Role of the mu 1 protein in re ...... omium release from host cells.
@en
prefLabel
Role of the mu 1 protein in re ...... omium release from host cells.
@ast
Role of the mu 1 protein in re ...... omium release from host cells.
@en
P2860
P1433
P1476
Role of the mu 1 protein in re ...... romium release from host cells
@en
P2093
B N Fields
J W Hooper
P2860
P304
P407
P577
1996-01-01T00:00:00Z