Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration.
about
The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomesThe genetics and neuropathology of frontotemporal lobar degenerationMechanisms of granulin deficiency: lessons from cellular and animal modelsLysosome size, motility and stress response regulated by fronto-temporal dementia modifier TMEM106BThe ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway.TMEM106B expression is reduced in Alzheimer's disease brainsRegulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a).Transmembrane protein 106A is silenced by promoter region hypermethylation and suppresses gastric cancer growth by inducing apoptosisGenome-wide association studies in neurology.Reassessment of risk genotypes (GRN, TMEM106B, and ABCC9 variants) associated with hippocampal sclerosis of aging pathologyThe TMEM106B locus and TDP-43 pathology in older persons without FTLDTransmembrane protein 106a activates mouse peritoneal macrophages via the MAPK and NF-κB signaling pathways.A novel Alzheimer disease locus located near the gene encoding tau protein.Frontotemporal dementia caused by CHMP2B mutation is characterised by neuronal lysosomal storage pathology.Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin.TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways.An extended proteome map of the lysosomal membrane reveals novel potential transporters.TMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia.Progranulin promotes peripheral nerve regeneration and reinnervation: role of notch signaling.Expression of TMEM106B, the frontotemporal lobar degeneration-associated protein, in normal and diseased human brain.Increased expression of the frontotemporal dementia risk factor TMEM106B causes C9orf72-dependent alterations in lysosomes.Elevated TMEM106B levels exaggerate lipofuscin accumulation and lysosomal dysfunction in aged mice with progranulin deficiencyTMEM106B protects C9ORF72 expansion carriers against frontotemporal dementia.TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions.Genetics of FTLD: overview and what else we can expect from genetic studies.TiME for TMEM106B"New Old Pathologies": AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS).ROS1 fusions in cancer: a review.What we know about TMEM106B in neurodegeneration.Molecular Genetics of Neurodegenerative Dementias.Subcellular Trafficking of Mammalian Lysosomal Proteins: An Extended View.Multifaceted role of SMCR8 as autophagy regulator.TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons.Quantitative proteomics reveals a role for epigenetic reprogramming during human monocyte differentiation.The Lysosomal Trafficking Transmembrane Protein 106B Is Linked to Cell Death.The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and function.A recurrent de novo mutation in TMEM106B causes hypomyelinating leukodystrophy.A Dementia-Associated Risk Variant near TMEM106B Alters Chromatin Architecture and Gene Expression.Progranulin: a new avenue towards the understanding and treatment of neurodegenerative disease.Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice.
P2860
Q24314869-E4F64234-9E61-443D-835C-B0752D8E19ABQ24615201-8AC10DEB-2F68-428F-84CF-2EC8C9551E41Q26824221-900BC2A9-10BE-486D-B1D4-96AD5017461FQ28585799-B1700C3B-33DE-4FD1-99BA-274C8E84667AQ29465536-F0049EBC-ED6F-42E9-9849-98FBD675E70BQ33746240-F225DD1F-BFCF-4817-B5DD-396689E96365Q33888606-A28EBD14-7667-4F26-9A29-F3A0D3ABB3B8Q34311246-438AF4D1-2872-463E-ABFE-18737003621EQ34658391-94316682-77A3-4195-A90B-6C91FB58D638Q34734941-B53037E4-71A4-4F3D-82BE-0FE726444BD3Q35153681-7825B1FD-70DB-401D-8A38-E1A9DF09AA35Q35894863-000F0326-4229-4BBD-881B-BCBF070A0A06Q36070145-6CB3B8C6-09F1-4981-85E0-FCC6D48E38B7Q36073666-E5B8D00F-7E70-4AF8-A433-00F83B1C3B56Q36078240-B579E66C-1932-4576-A568-9B1AD386014EQ36247028-82FDCE87-6761-4E99-8EAE-4DA16A74E9B7Q36910788-14879B63-412A-477F-9286-BA7F45A5FAE9Q37154601-F524B9ED-C943-4CDE-91E3-36AC86D59225Q37359314-8AAE0EB6-9E8A-49F0-9EE5-90647E346705Q37485507-1CB692BE-4DD6-4697-9D96-C624C50C159DQ37530270-CABAAA6B-1C2C-4491-A0DD-49D1D9402453Q37609848-A5E6B139-326D-4DE3-A9A9-077D3DFC1C25Q37621660-1B94C520-05A1-4807-8E8F-E9DF1E3C819DQ37730909-D8A93611-4130-41EE-A587-8DDF4E4E2C78Q38786774-4A4F81A6-E647-46F0-8970-7FEC7A1F3B40Q38797600-69199346-91A5-4E86-82A9-3731AE665B8CQ38841003-E762CBAC-4C94-4D61-B35E-F706E3A6C1EFQ38852070-ACE0223F-B45C-4C11-8408-0C052F3A9C1FQ38932474-A2767DEF-8EA8-48F1-B75F-261462C48853Q39035458-F56AA41D-138F-4754-841B-256F6AD4F22CQ39063017-90CF9291-533C-43CB-AE58-4E9374FB9D8BQ39428501-6598F435-161C-410C-BD15-C913A21B04E2Q41644307-12B152F2-5B32-489C-BF85-A84C99BD3DFFQ41700803-E67DFB13-263D-40DE-BBE1-F4D079265475Q42089594-0D5FE38D-F990-4317-A716-0B3A269C9CC0Q42962467-860F0D0F-1C77-44BF-B6FD-2272C07D617BQ46317492-4C674D5F-72B9-40DE-A70F-F544DDA81CBAQ47620193-F3AE31D5-4DC9-43C3-84C7-1CA0057FB107Q47623958-725ACE14-AED2-4D83-8883-2E66941A417DQ48187381-BCDD8852-D904-407C-ADE8-1BE69CEAB704
P2860
Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Membrane orientation and subce ...... totemporal lobar degeneration.
@ast
Membrane orientation and subce ...... totemporal lobar degeneration.
@en
type
label
Membrane orientation and subce ...... totemporal lobar degeneration.
@ast
Membrane orientation and subce ...... totemporal lobar degeneration.
@en
prefLabel
Membrane orientation and subce ...... totemporal lobar degeneration.
@ast
Membrane orientation and subce ...... totemporal lobar degeneration.
@en
P2093
P2860
P50
P356
P1476
Membrane orientation and subce ...... totemporal lobar degeneration.
@en
P2093
Benjamin M Schwenk
Christina M Lang
Elisabeth Kremmer
Katrin Fellerer
P2860
P304
19355-19365
P356
10.1074/JBC.M112.365098
P407
P577
2012-04-17T00:00:00Z