A role for Pak protein kinases in Schwann cell transformation.
about
p21-Activated kinase 1 (Pak1) phosphorylates BAD directly at serine 111 in vitro and indirectly through Raf-1 at serine 112S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3FRAX597, a Small Molecule Inhibitor of the p21-activated Kinases, Inhibits Tumorigenesis of Neurofibromatosis Type 2 (NF2)-associated SchwannomasCdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity.Interaction between active Pak1 and Raf-1 is necessary for phosphorylation and activation of Raf-1Akt phosphorylation of serine 21 on Pak1 modulates Nck binding and cell migrationActivated PAK4 regulates cell adhesion and anchorage-independent growthCdc42 in oncogenic transformation, invasion, and tumorigenesisNeurofibromatosis type 1 - a model for nervous system tumour formation?Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitroComprehensive pharmacological profiling of neurofibromatosis cell lines.p21-Activated kinases are required for transformation in a cell-based model of neurofibromatosis type 2.Molecular pathways: targeting RAC-p21-activated serine-threonine kinase signaling in RAS-driven cancersActive p21-activated kinase 1 rescues MCF10A breast epithelial cells from undergoing anoikis.The Retinoblastoma Tumor Suppressor Transcriptionally Represses Pak1 in Osteoblasts.Brazilian Red Propolis Attenuates Inflammatory Signaling Cascade in LPS-Activated Macrophages.Tumor suppressor mutations and growth factor signaling in the pathogenesis of NF1-associated peripheral nerve sheath tumors. I. The role of tumor suppressor mutations.p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model.Pak protein kinases and their role in cancer.Malignant peripheral nerve sheath tumour (MPNST): the clinical implications of cellular signalling pathways.PAK signaling in cancer.Herbal therapeutics that block the oncogenic kinase PAK1: a practical approach towards PAK1-dependent diseases and longevity.P21 activated kinases: structure, regulation, and functions.Rho GTPases modulate malignant transformation of tumor cells.Targeting PAK1.Targeting group I p21-activated kinases to control malignant peripheral nerve sheath tumor growth and metastasis.Inhibition of MEK pathway in vestibular schwannoma cell culture.Signals from the Ras, Rac, and Rho GTPases converge on the Pak protein kinase in Rat-1 fibroblasts.P-21-activated protein kinase-1 functions as a linker between insulin and Wnt signaling pathways in the intestine.Induction of apoptosis in neurofibromatosis type 1 malignant peripheral nerve sheath tumor cell lines by a combination of novel farnesyl transferase inhibitors and lovastatin.Independent activation of endogenous p21-activated protein kinase-3 (PAK3) and JNK by thrombin in CCL39 fibroblasts.Pak4 induces premature senescence via a pathway requiring p16INK4/p19ARF and mitogen-activated protein kinase signaling.Fragile x mental retardation 1 and filamin a interact genetically in Drosophila long-term memory.Requirement for PAK4 in the anchorage-independent growth of human cancer cell lines.A role for Gab1/SHP2 in thrombin activation of PAK1: gene transfer of kinase-dead PAK1 inhibits injury-induced restenosis.Microtubule integrity regulates Pak leading to Ras-independent activation of Raf-1. insights into mechanisms of Raf-1 activation.Expression of Rho-family GTPases (Rac, cdc42, RhoA) and their association with p-21 activated kinase in adult rat peripheral nerve.
P2860
Q21134956-42939298-0C15-4E45-8136-7D73C0438D27Q24550986-6B66F0E2-599F-43DB-8F70-17DE89CFDED0Q27679769-E4838436-C700-452A-8FA3-2E05DE214C76Q27939243-22E17BCC-5BE4-494A-8FA4-BEA1DCB2D8C3Q28208695-E94C0C9B-00C0-404A-BA8B-870089F8919EQ28213453-443E22EF-8E14-4849-B78F-DAA5CEB27301Q28213663-E5D81121-722E-4EB8-B081-ACA0DACEF3B1Q28236231-7B72C721-40C7-4879-9E60-F7DECAF4C52EQ28265284-A6BB1E99-F43F-4759-A6C1-D51E5E8AF7E1Q28594862-99F4FB34-D51D-4F48-BE29-D528A192140BQ33622690-745E5381-0C3C-4518-8BF5-9B4E05C58B9DQ33745071-55B17EEF-CE86-47FC-9177-FEE8734DC2E1Q34200109-626B1A08-DB96-43A8-AAA3-CFF22E2C9C87Q34768946-9B81E517-2103-4664-880D-E6D51BCCF3C2Q35837201-28A3631A-447D-483C-BE29-3244E8229511Q35867602-B07F5C6F-4CEE-4881-8C40-0105525BC6BFQ35973936-DC914D2F-F3E6-4305-8721-D3A40C819DE6Q36405845-E3E6F74A-87FB-449D-86A2-C4511F04AFA7Q37376062-2C353947-7A3A-4BA5-B234-A948D1618D75Q37616238-5BADD236-6B55-4EC9-BA0A-EDB93DAFCD7BQ38060732-E6C1BF04-6BB3-49EB-A34A-729AA5B2A6FAQ38128777-D287BFEA-9AE6-4BEF-AF12-32DA11164A59Q38198494-74F6849D-33B6-484F-9E91-F3C060E67302Q38230951-7D931CBE-AAEB-4012-B4D3-C996187622E0Q38757029-256D17AF-B961-47A6-B5DB-146DE0EFC615Q38769437-EE4AAC63-F7D0-4D2B-B3F7-08CAF2C4B392Q39298876-B3D23B38-F28C-4301-8DFE-887E05C8D43EQ39444795-B32D838E-6596-42F9-8C3E-A1D2E14252F8Q39828329-3A5A45E7-3A21-429D-90F8-64BCADC1E785Q39998302-6D2F6395-D60D-4E73-A737-EE200E278E50Q40850226-5DA23FF6-3B42-40AF-80F0-C174AF43E2F8Q41978548-8E4B1BA4-36F7-4A08-8D10-72E0566AD0B9Q42042638-B91C0492-80DC-406A-8550-CF94A27F8037Q42824450-00697EB4-A123-4860-A107-AB2A63A7DBC2Q42926016-2C027366-92ED-49F6-97D4-1003C76AE3E3Q43556620-AD4A9140-5B6B-42D8-98FA-4454EB50ACA1Q48874872-35988CA2-E7F8-4B86-B480-1C7CAE2B6497
P2860
A role for Pak protein kinases in Schwann cell transformation.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
A role for Pak protein kinases in Schwann cell transformation.
@ast
A role for Pak protein kinases in Schwann cell transformation.
@en
type
label
A role for Pak protein kinases in Schwann cell transformation.
@ast
A role for Pak protein kinases in Schwann cell transformation.
@en
prefLabel
A role for Pak protein kinases in Schwann cell transformation.
@ast
A role for Pak protein kinases in Schwann cell transformation.
@en
P2093
P2860
P356
P1476
A role for Pak protein kinases in Schwann cell transformation.
@en
P2093
G I Tennekoon
J L Rutkowski
P C Phillips
P2860
P304
P356
10.1073/PNAS.95.9.5139
P407
P577
1998-04-01T00:00:00Z