A role for Cdk2 kinase in negatively regulating DNA replication during S phase of the cell cycle.
about
Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cellsDNA replication at the single-molecule levelThe cell cycle regulator p27Kip1 interacts with MCM7, a DNA replication licensing factor, to inhibit initiation of DNA replicationMCM-BP regulates unloading of the MCM2-7 helicase in late S phaseXenopus Cdc45-dependent loading of DNA polymerase alpha onto chromatin under the control of S-phase Cdk.Identification of a binding region for human origin recognition complex proteins 1 and 2 that coincides with an origin of DNA replicationLoss of rereplication control in Saccharomyces cerevisiae results in extensive DNA damageChanges in association of the Xenopus origin recognition complex with chromatin on licensing of replication originsChromosome association of minichromosome maintenance proteins in Drosophila endoreplication cyclesIdentification of a preinitiation step in DNA replication that is independent of origin recognition complex and cdc6, but dependent on cdk2G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus.The human origin recognition complex protein 1 dissociates from chromatin during S phase in HeLa cellsThe potential role of As-sumo-1 in the embryonic diapause process and early embryo development of Artemia sinicaPersistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutantsLicensing of Centromeric Chromatin Assembly through the Mis18α-Mis18β Heterotetramer.Acute reduction of an origin recognition complex (ORC) subunit in human cells reveals a requirement of ORC for Cdk2 activation.Aberrant DNA polymerase alpha is excluded from the nucleus by defective import and degradation in the nucleusXic1 degradation in Xenopus egg extracts is coupled to initiation of DNA replication.Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts.Association of RPA with chromosomal replication origins requires an Mcm protein, and is regulated by Rad53, and cyclin- and Dbf4-dependent kinases.Protein phosphatase 2A regulates binding of Cdc45 to the prereplication complex.Cut5 is required for the binding of Atr and DNA polymerase alpha to genotoxin-damaged chromatin.Developmental activation of the Rb-E2F pathway and establishment of cell cycle-regulated cyclin-dependent kinase activity during embryonic stem cell differentiationCell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation.Timing of cyclin E gene expression depends on the regulated association of a bipartite repressor element with a novel E2F complex.Genetic analysis of mammalian cyclin-dependent kinases and their inhibitors.Cell cycle-dependent regulation of human DNA polymerase alpha-primase activity by phosphorylation.Control of chromosomal DNA replication in the early Xenopus embryo.Checkpoint genes in cancer.Control of DNA replication and chromosome ploidy by geminin and cyclin AIdentification of the nuclear localization signal in Xenopus cyclin E and analysis of its role in replication and mitosis.Cell cycle- and chromatin binding state-dependent phosphorylation of human MCM heterohexameric complexes. A role for cdc2 kinase.Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by gemininProtein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpointReplication licensing--defining the proliferative state?Replication licensing and the DNA damage checkpoint.A genetic screen for suppressors and enhancers of the Drosophila PAN GU cell cycle kinase identifies cyclin B as a target.Nuclear accumulation of cyclin E/Cdk2 triggers a concentration-dependent switch for the destruction of p27Xic1.Cell cycle control of chorion gene amplificationEukaryotic MCM proteins: beyond replication initiation.
P2860
Q22010574-BCE962F1-9D8A-4ACD-B386-960E923B306AQ22121971-D8AE80FA-C3C4-4FAB-A2CC-0329FFED0C50Q24295113-A7B473BB-1462-41C7-95BC-B50183346795Q24322662-02183B11-F944-428E-A7EB-C22CC29858E1Q24533333-7DD43386-D2EE-463D-BDE9-0817CA6953F8Q24537498-92DD11CF-2A29-4D61-A79C-E55DA2C892A3Q24558657-93AAD0D4-D88B-4D62-8384-FD6A8351B355Q24600305-67E2F858-FCBF-42DE-BA0B-0F0145419519Q24678160-F54CDF4D-7830-4426-81E9-891234698D49Q24683693-CFD884E7-96A5-45BC-9EFA-45F1F899E86DQ27937350-C2FC725E-EF2D-4AEB-A6B9-635E09809934Q28139209-5E242F9B-53BC-4187-8625-01143158E56CQ28660863-C57A7703-587F-46FD-A03D-EFFA733D6D84Q29614856-7EBAFFAD-9990-4DDD-A2C8-8D312290516CQ30277213-80C27548-6C5E-4DD0-91A0-935DC843D4A4Q30437070-324E9023-6ED4-4E85-878E-5FFFF46F2D6FQ30491813-60A2260B-301A-4AD9-A914-908AE4E3C46CQ31060526-BB28FE61-352B-46E2-A910-39CB0F9993E2Q31136186-B696DE48-1A81-4897-B790-5579B98587A0Q32028781-D5D81F54-8494-4759-86C3-D2723D778FC4Q33184133-28293382-0238-43ED-9F22-CD8E4353BC2CQ33193630-6B463AA0-F4E1-48B9-B21E-17959B53561AQ33734599-EAF64DA5-DDF3-44C2-B6FF-ED7E5E650C2DQ33872351-AC98223E-2B0A-4195-950D-70C0B6FE8DECQ33890688-FD2D4130-ABEC-4222-A9F4-084400A7FEF8Q33925119-60790942-CCF9-4DBF-9E58-AA18F2465432Q33957212-81250915-6E05-40A4-AFB4-EAF2BCA7A8FAQ34080275-3D52F00E-8AFD-441A-B75B-50107490DC38Q34235181-43EB4D4A-D864-432A-BCF5-1989CB89EC6AQ34323837-66A6F724-9A4A-409A-B23C-543BABBE7EFFQ34417402-B30085CC-9511-4475-875E-661981AD59C4Q34473489-C90B957A-9144-4CF0-B2A4-AF6F28993C33Q34513299-C56EB100-F495-4062-843C-9829B8F0799DQ34519707-1BA559F5-AD33-487B-B7ED-4B35A0C1AB8BQ34534992-6D054253-5A06-4117-AFC4-2AE99A72317EQ34547673-CA5EFB19-1DB1-428C-B835-9883929A2372Q34613014-95B0318F-14AF-47DC-AB4C-42263626C253Q35168200-5EED7382-16C0-492F-93E8-60732F9F5868Q35192801-BB625F09-790D-4920-B932-4B86C5DA3CE4Q35684975-58EE8D5C-9595-4285-BC85-96CE5A20BB0D
P2860
A role for Cdk2 kinase in negatively regulating DNA replication during S phase of the cell cycle.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
A role for Cdk2 kinase in nega ...... ing S phase of the cell cycle.
@ast
A role for Cdk2 kinase in nega ...... ing S phase of the cell cycle.
@en
type
label
A role for Cdk2 kinase in nega ...... ing S phase of the cell cycle.
@ast
A role for Cdk2 kinase in nega ...... ing S phase of the cell cycle.
@en
prefLabel
A role for Cdk2 kinase in nega ...... ing S phase of the cell cycle.
@ast
A role for Cdk2 kinase in nega ...... ing S phase of the cell cycle.
@en
P2093
P2860
P356
P1476
A role for Cdk2 kinase in nega ...... ing S phase of the cell cycle.
@en
P2093
P2860
P304
P356
10.1083/JCB.137.1.183
P407
P577
1997-04-01T00:00:00Z