Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia - Wikidata - awgldk - TriplyDB

Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia

Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia

http://www.wikidata.org/entity/Q36487090

about

Potential Therapeutical Contributions of the Endocannabinoid System towards Aging and Alzheimer's Disease Alzheimer's disease: new data highlight nonneuronal cell types and the necessity for presymptomatic prevention strategies A deficiency in CCR2+ monocytes: the hidden side of Alzheimer's disease Innate immunity in Alzheimer's disease: a complex affair Oxidized cholesterol as the driving force behind the development of Alzheimer's disease Bidirectional microglia-neuron communication in the healthy brain Microglia development and function Functional impairment of microglia coincides with Beta-amyloid deposition in mice with Alzheimer-like pathology Neuroinflammation in Alzheimer's disease In vivo imaging of microglial activation by positron emission tomography with [(11)C]PBR28 in the 5XFAD model of Alzheimer's disease Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion Inflammatory Stress on Autophagy in Peripheral Blood Mononuclear Cells from Patients with Alzheimer's Disease during 24 Months of Follow-Up Amyloid-β-induced astrocytic phagocytosis is mediated by CD36, CD47 and RAGE Epigenetic suppression of neuroligin 1 underlies amyloid-induced memory deficiency Drivers of age-related inflammation and strategies for healthspan extension Mechanisms underlying inflammation in neurodegeneration Microglia as a critical player in both developmental and late-life CNS pathologies.Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice.Microfluidic chemotaxis platform for differentiating the roles of soluble and bound amyloid-β on microglial accumulation.Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease.In vivo dynamics of innate immune sentinels in the CNS.Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease.Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Aβ by microglia Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology.Abeta-directed single-chain antibody delivery via a serotype-1 AAV vector improves learning behavior and pathology in Alzheimer's disease mice.Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2.New insights on the role of microglia in synaptic pruning in health and disease Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease.Proliferation in the Alzheimer hippocampus is due to microglia, not astroglia, and occurs at sites of amyloid deposition.Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function Acute reduction of microglia does not alter axonal injury in a mouse model of repetitive concussive traumatic brain injury.CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models.Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimer's disease Deletion of CD14 attenuates Alzheimer's disease pathology by influencing the brain's inflammatory milieu.Immunolesion-induced loss of cholinergic projection neurones promotes β-amyloidosis and tau hyperphosphorylation in the hippocampus of triple-transgenic mice.CD45 deficiency drives amyloid-β peptide oligomers and neuronal loss in Alzheimer's disease mice Comparison of conventional ELISA with electrochemiluminescence technology for detection of amyloid-β in plasma CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-β phagocytosis.How to get from here to there: macrophage recruitment in Alzheimer's disease Homeostatic and injury-induced microglia behavior in the aging brain.

P2860

Q26783325-3EC7CEF4-D92E-4E9C-B205-4C635ED19988 Q26852851-5ED17D10-5896-4182-972E-BA0274B7C341 Q26997058-1C9834C5-C9D9-4E90-AEBD-AD0EEB38EA84 Q27006944-F1AA1F65-C95B-4464-A99C-86F404A27B9C Q27023315-6B62D93A-3787-4477-A3D5-03234A2AA16A Q27024873-FD50ED93-126F-40A7-A175-59F8B4A4172E Q27316453-B576BE61-3BF0-4324-ABE8-2DB04BF14A4B Q27327835-193F9B97-048B-4763-A3F0-BD27CC6867B2 Q28259238-667589DD-2D61-49AB-808B-3BC645258A96 Q28274003-A12EF7AA-EF36-4A00-A0B3-9AA1C957F796 Q28294279-46F5C8AD-BE13-4F90-B9D4-62EFE31E6BFD Q28548344-0E70EE3C-FA47-4F9D-BA0D-91EC1768F654 Q28576584-40C739B7-FFEF-46FC-8DF8-6B44C25C8CD9 Q28583995-7F3611CE-838F-42CE-BA63-D246878690E8 Q28649560-DC776874-8CB0-48E7-9514-B9BB9FD23422 Q29617977-F2E9426D-F743-42CC-B7E4-CC0BA2A3AEB6 Q30411278-A989A5FF-13A7-4509-84AC-C9123A10B481 Q30530388-891C88FE-2F39-436F-836C-F2C2951A0A9B Q30539682-5348CFB1-D500-4965-B2BA-E5FE47F83718 Q30545790-F5BC83F1-7722-405A-B158-D0FD3D0778CE Q30547038-978B4356-A54E-460C-B593-CAAC6F12B4C7 Q30581719-E936CA79-DB66-4CF4-98EB-A1619366978B Q30665205-80FD248F-143D-4692-A5AD-7F66C13EC62F Q30805627-1E8BA8FE-1141-44CA-A1B6-C36A306D12E8 Q33605644-B1F9994F-9BB6-4A56-B268-714425C4B8DC Q33727947-2D84B616-0F0D-41A7-8BBC-358258CA8F3C Q33821505-E2F8F87C-D601-4933-A0A1-AB339D51073E Q33999537-E88C3E1A-793F-4008-A9F9-5D2426DB95E6 Q34146055-52CF770D-6EE6-41E6-8FFD-DBDB7CB84DA5 Q34172143-0C572988-BD11-45DB-90B7-E52F68172DA3 Q34223717-679A1968-90D4-42A5-865B-C309DF0E214C Q34254575-8AB5BD2D-E967-4067-BE30-4F013FBE25A6 Q34306241-1EC3C6E4-DF08-47BB-B9D7-8D9D270C847C Q34383143-DAF91CCD-3A0C-4C61-AAB1-6C10155C2EBA Q34659234-67776848-54E1-41BC-9329-BD810DAD2430 Q34744169-C11893BF-82D3-4BEE-94C8-7DFE84FA826E Q34786869-07FF7BEA-E87E-4471-A3DF-3FA0C50A6143 Q34796584-B3C31EDD-9C11-418E-825D-22EA8829D74F Q34912085-AEDA1934-DBA2-4782-ABA0-D275BB133428 Q34953779-1299ADF2-C384-49B3-BBA9-CBBF3B4BB042

P2860

Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia

http://www.wikidata.org/entity/Q36487090

description

2009 nî lūn-bûn

@nan

2009年の論文

@ja

2009年学术文章

@wuu

2009年学术文章

@zh-cn

2009年学术文章

@zh-hans

2009年学术文章

@zh-my

2009年学术文章

@zh-sg

2009年學術文章

@yue

2009年學術文章

@zh

2009年學術文章

@zh-hant

name

Formation and maintenance of A ...... es in the absence of microglia

@ast

Formation and maintenance of A ...... es in the absence of microglia

@en

type

label

Formation and maintenance of A ...... es in the absence of microglia

@ast

Formation and maintenance of A ...... es in the absence of microglia

@en

prefLabel

Formation and maintenance of A ...... es in the absence of microglia

@ast

Formation and maintenance of A ...... es in the absence of microglia

@en

P1433

Q36487090-18669D3A-E6F4-4522-B468-19CC11C36F48

P1476

Q36487090-C8D65B7A-A9A4-4D9D-9B39-05957C43CA42

P2093

Q36487090-05E52F35-DD15-4FC6-8CC7-1FD09C253255

Q36487090-1588F9F0-2E06-464A-A3EA-BFA6DACAF2C1

Q36487090-1C43B1D3-32E4-4AD0-99F0-200F91BF32C0

Q36487090-24649D61-56B1-4F29-BC9C-CEEE6271D2D0

Q36487090-473F1C59-B2D0-4A30-82D1-D9EC4ED0B43F

Q36487090-6054E978-91C1-46A9-9279-67F877214F4C

Q36487090-7808CE55-C06D-4C35-9436-0360CBA3D4FB

Q36487090-83804395-E25D-434A-B8B5-73254A086B72

Q36487090-B6F7C6A5-18A9-44B6-8C3C-51DBE94CF463

Q36487090-B8212A0F-F01E-4EC2-8CF0-A3FEB8D12B9D

P2860

Q36487090-087056A4-F982-4B51-AABF-CF0BAC00D2A2

Q36487090-2B137D95-1ABC-470E-8B34-C8C6BB79C30E

Q36487090-4939FE9B-9D84-4BF1-9A43-1500858ABBA2

Q36487090-71A8314E-D245-4061-9614-2D8724EE2260

Q36487090-785B0445-962C-4021-85FB-5F58C735E63D

Q36487090-7A6C5C21-CA44-4DD5-9659-BB59276DA857

Q36487090-82013D3D-A0EF-4EC5-9E21-5EB2725C53FB

Q36487090-8AD8D4D3-77B9-438D-8FAE-BBABF43038C6

Q36487090-96FFDE0F-3B0E-415A-ABC4-381F29693276

Q36487090-A07C0174-219C-41F8-A4AA-219DF0889612

P2888

Q36487090-7CBE0452-4210-4E16-8E20-8B50DBD2449B

P304

Q36487090-E0DDF7ED-FFBB-49FC-95F0-D6C89F07B477

P31

Q36487090-1FBF010F-54C2-4635-8A12-0B06909F30BA

P356

Q36487090-EB0FCB05-ABD1-4A16-8C43-ED540F3BD9CE

P407

Q36487090-AF6FDA08-6DC8-4856-A549-A6F00CE6A6C4

P433

Q36487090-4F53F657-E435-4D17-80AC-5A6881E9A810

P478

Q36487090-05D075B2-D26D-408F-9260-492B23A85A76

P50

Q36487090-4EC20435-24F0-4D5E-A445-8EE4E34E4DF3

Q36487090-696751C0-F364-45FC-ABC4-717C5D1BC64B

Q36487090-74810365-D96E-4BCD-9A37-72BAD126E010

Q36487090-8D9D1C2F-E20C-4685-8C73-DD3931ACE2BA

Q36487090-AB14B2A3-5FF3-48E1-B869-7F704762DC22

P577

Q36487090-49D2E27D-72E8-44F5-87EA-8618BE66EB03

P5875

Q36487090-8F95386A-BEE1-44FA-98D0-161A66193E0C

P698

Q36487090-8E7C4E0C-8B54-4A19-A9B6-8C831374E42C

P921

Q36487090-130EB152-455F-4D0D-A2D0-61D00307597F

Q36487090-82F425BC-336A-4D42-B2AD-978692EC2D67

P932

Q36487090-61B2E531-F2FC-45EB-998B-6086891A0958

P356

P1433

Nature Neuroscience

P1476

Formation and maintenance of A ...... es in the absence of microglia

@en

P2093

Frank L Heppner

http://www.w3.org/2001/XMLSchema#string

Georg Winkelmann

http://www.w3.org/2001/XMLSchema#string

Hartwig Wolburg

http://www.w3.org/2001/XMLSchema#string

Jörg Odenthal

http://www.w3.org/2001/XMLSchema#string

Rebecca Radde

http://www.w3.org/2001/XMLSchema#string

Roland E Kälin

http://www.w3.org/2001/XMLSchema#string

Sam Gandy

http://www.w3.org/2001/XMLSchema#string

Stefan A Grathwohl

http://www.w3.org/2001/XMLSchema#string

Stephan A Kaeser

http://www.w3.org/2001/XMLSchema#string

Therese Eldh

http://www.w3.org/2001/XMLSchema#string

P2860

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

Microglia: active sensor and versatile effector cells in the normal and pathologic brain

Amyloid-beta immunotherapy for Alzheimer's disease: the end of the beginning.

Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology.

Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease

Association of microglia with amyloid plaques in brains of APP23 transgenic mice.

Inflammation in Alzheimer disease: driving force, bystander or beneficial response?

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology.

Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology.

Cerebral and peripheral amyloid phagocytes--an old liaison with a new twist.

P2888

P304

1361-1363

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/NN.2432

http://www.w3.org/2001/XMLSchema#string

P407

P433

11

http://www.w3.org/2001/XMLSchema#string

P478

12

http://www.w3.org/2001/XMLSchema#string

P50

Matthias Staufenbiel

P577

2009-10-18T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

38019324

http://www.w3.org/2001/XMLSchema#string

P698

19838177

http://www.w3.org/2001/XMLSchema#string

P921

Alzheimer's disease

P932

4721582

http://www.w3.org/2001/XMLSchema#string