Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide - Wikidata - awgldk - TriplyDB

Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide

Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide

http://www.wikidata.org/entity/Q36961011

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Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase Anandamide and vanilloid TRPV1 receptors Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes Structure-guided inhibitor design for human FAAH by interspecies active site conversion Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain Binding and Inactivation Mechanism of a Humanized Fatty Acid Amide Hydrolase by α-Ketoheterocycle Inhibitors Revealed from Cocrystal Structures X-ray Crystallographic Analysis of α-Ketoheterocycle Inhibitors Bound to a Humanized Variant of Fatty Acid Amide Hydrolase Fluoride-Mediated Capture of a Noncovalent Bound State of a Reversible Covalent Enzyme Inhibitor: X-ray Crystallographic Analysis of an Exceptionally Potent α-Ketoheterocycle Inhibitor of Fatty Acid Amide Hydrolase Reversible Competitive α-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational Constraints in the Acyl Side Chain: Orally Active, Long-Acting Analgesics Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH)Rational Design of Fatty Acid Amide Hydrolase Inhibitors That Act by Covalently Bonding to Two Active Site Residues Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase: New Targets for Future Antidepressants Preclinical Characterization of the FAAH Inhibitor JNJ-42165279 Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders Latest advances in the discovery of fatty acid amide hydrolase inhibitors Effects of homologues and analogues of palmitoylethanolamide upon the inactivation of the endocannabinoid anandamide Enzymatic pathways that regulate endocannabinoid signaling in the nervous system Keys to Lipid Selection in Fatty Acid Amide Hydrolase Catalysis: Structural Flexibility, Gating Residues and Multiple Binding Pockets α-Ketoheterocycle inhibitors of fatty acid amide hydrolase: exploration of conformational constraints in the acyl side chain.The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).Assessment of the pharmacology and tolerability of PF-04457845, an irreversible inhibitor of fatty acid amide hydrolase-1, in healthy subjects.Discovery libraries targeting the major enzyme classes: the serine hydrolases.Mast cells promote fibroblast populated collagen lattice contraction through gap junction intercellular communication.Control of spasticity in a multiple sclerosis model is mediated by CB1, not CB2, cannabinoid receptors.A new class of inhibitors of 2-arachidonoylglycerol hydrolysis and invasion of prostate cancer cells.Endocannabinoid modulation by FAAH and monoacylglycerol lipase within the analgesic circuitry of the periaqueductal grey The cannabinoid system: a role in both the homeostatic and hedonic control of eating?Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models.Chemical strategies for activity-based proteomics.The endocannabinoid system: physiology and pharmacology.α-Ketoheterocycle-based Inhibitors of Fatty Acid Amide Hydrolase (FAAH).Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates.Clickable, photoreactive inhibitors to probe the active site microenvironment of fatty acid amide hydrolase().Changes of blood endocannabinoids during anaesthesia: a special case for fatty acid amide hydrolase inhibition by propofol?New targets for neuropathic pain therapeutics.Supraspinal modulation of pain by cannabinoids: the role of GABA and glutamate Comprehensive Analysis of Structure-Activity Relationships of α-Ketoheterocycles as sn-1-Diacylglycerol Lipase α Inhibitors Hemodynamic profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase.Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597).Identification of N-acylethanolamines in Dictyostelium discoideum and confirmation of their hydrolysis by fatty acid amide hydrolase.

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Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide

http://www.wikidata.org/entity/Q36961011

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2000 nî lūn-bûn

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2000年の論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年论文

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2000年论文

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2000年论文

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name

Exceptionally potent inhibitor ...... genous oleamide and anandamide

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Exceptionally potent inhibitor ...... genous oleamide and anandamide

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Exceptionally potent inhibitor ...... genous oleamide and anandamide

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PNAS.97.10.5044

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Proceedings of the National Academy of Sciences of the United States of America

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Exceptionally potent inhibitor ...... genous oleamide and anandamide

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P2093

A E Lerner

http://www.w3.org/2001/XMLSchema#string

B F Cravatt

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B J Austin

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D L Boger

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G D Wilkie

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H Miyauchi

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H Sato

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M P Hedrick

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M P Patricelli

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R A Fecik

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P2860

Molecular characterization of human and mouse fatty acid amide hydrolases

Inhibition of human neutrophil elastase. 4. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of P2-modified, orally active peptidyl pentafluoroethyl ketones

Fatty acid amide hydrolase competitively degrades bioactive amides and esters through a nonconventional catalytic mechanism

Anandamide may mediate sleep induction

Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist

Anandamide modulates sleep and memory in rats

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

Chemical characterization of a family of brain lipids that induce sleep

Methyl arachidonyl fluorophosphonate: a potent irreversible inhibitor of anandamide amidase

Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide

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5044-5049

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10

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12511584

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10805767

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25778

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