N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma. - Wikidata - awgldk - TriplyDB

N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma.

N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma.

http://www.wikidata.org/entity/Q37111115

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A small-molecule smoothened agonist prevents glucocorticoid-induced neonatal cerebellar injury Control of the Normal and Pathological Development of Neural Stem and Progenitor Cells by the PC3/Tis21/Btg2 and Btg1 Genes Proper formation of whisker barrelettes requires periphery-derived Smad4-dependent TGF-beta signaling In vivo Mn-enhanced MRI for early tumor detection and growth rate analysis in a mouse medulloblastoma model.N-Myc regulates expression of pluripotency genes in neuroblastoma including lif, klf2, klf4, and lin28b.Mouse models for cancer stem cell research.Huwe1 ubiquitin ligase is essential to synchronize neuronal and glial differentiation in the developing cerebellum The p53 inhibitor MDM2 facilitates Sonic Hedgehog-mediated tumorigenesis and influences cerebellar foliation Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway c-myc and N-myc promote active stem cell metabolism and cycling as architects of the developing brain.Nos2 inactivation promotes the development of medulloblastoma in Ptch1(+/-) mice by deregulation of Gap43-dependent granule cell precursor migration.Widespread contribution of Gdf7 lineage to cerebellar cell types and implications for hedgehog-driven medulloblastoma formation.Suppression of Medulloblastoma Lesions by Forced Migration of Preneoplastic Precursor Cells with Intracerebellar Administration of the Chemokine Cxcl3.Intracranial orthotopic allografting of medulloblastoma cells in immunocompromised mice.MicroRNA-29b-1 impairs in vitro cell proliferation, self‑renewal and chemoresistance of human osteosarcoma 3AB-OS cancer stem cells.Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma.Targeted inhibition of histone deacetylases and hedgehog signaling suppress tumor growth and homologous recombination in aerodigestive cancers.Myc proteins in brain tumor development and maintenance.Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC.Bax deficiency prolongs cerebellar neurogenesis, accelerates medulloblastoma formation and paradoxically increases both malignancy and differentiation.Review: In vivo models for defining molecular subtypes of the primitive neuroectodermal tumor genome: current challenges and solutions.Bmi1 overexpression in the cerebellar granule cell lineage of mice affects cell proliferation and survival without initiating medulloblastoma formation.Medulloblastoma or not? Crucial role in tumorigenesis of the timing of migration of cerebellar granule precursor cells, regulated by Nos2 and Tis21 Role of MYC in Medulloblastoma.Role of nitric oxide in cerebellar development and function: focus on granule neurons.Review: personalized mice: modelling the molecular heterogeneity of medulloblastoma.What underlies the diversity of brain tumors?Modeling and Targeting MYC Genes in Childhood Brain Tumors.Norrin/Frizzled4 signalling in the preneoplastic niche blocks medulloblastoma initiation.Deletion of Atoh1 disrupts Sonic Hedgehog signaling in the developing cerebellum and prevents medulloblastoma.Pleiotropic role for MYCN in medulloblastoma.Combinations of genetic mutations in the adult neural stem cell compartment determine brain tumour phenotypes.On hedgehogs and human cancer.Geminin deficiency enhances survival in a murine medulloblastoma model by inducing apoptosis of preneoplastic granule neuron precursors.ATOH1 Promotes Leptomeningeal Dissemination and Metastasis of Sonic Hedgehog Subgroup Medulloblastomas.Dynamic expression of N-myc in mouse embryonic development using an enhanced green fluorescent protein reporter gene in the N-myc locus.Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo.Biological and clinical heterogeneity of MYCN-amplified medulloblastoma.

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N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma.

http://www.wikidata.org/entity/Q37111115

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on January 2009

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma.

@en

N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma.

@nl

type

label

N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma.

@en

N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma.

@nl

prefLabel

N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma.

@en

N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma.

@nl

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Genes & Development

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N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma.

@en

P2093

Brian A Emmenegger

http://www.w3.org/2001/XMLSchema#string

Fan Wang

http://www.w3.org/2001/XMLSchema#string

Hiroshi Hasegawa

http://www.w3.org/2001/XMLSchema#string

Jessica D Kessler

http://www.w3.org/2001/XMLSchema#string

John W Dutton

http://www.w3.org/2001/XMLSchema#string

Robert J Wechsler-Reya

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Sonja N Brun

http://www.w3.org/2001/XMLSchema#string

Zeng-Jie Yang

http://www.w3.org/2001/XMLSchema#string

P2860

The Hallmarks of Cancer

Cancerous stem cells can arise from pediatric brain tumors

Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

Identification of human brain tumour initiating cells

Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum

N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation

Clinical practice. Adenomatous polyps of the colon

The Hedgehog response network: sensors, switches, and routers

Pituitary adenylate cyclase-activating polypeptide and sonic hedgehog interact to control cerebellar granule precursor cell proliferation

The transmembrane semaphorin Sema6A controls cerebellar granule cell migration

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157-170

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scholarly article

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10.1101/GAD.1759909

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2

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23

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2009-01-01T00:00:00Z

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23950919

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19171780

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medulloblastoma

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2648542

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