Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease. - Wikidata - awgldk - TriplyDB

Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease.

Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease.

http://www.wikidata.org/entity/Q37402225

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Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways LRRK2 transport is regulated by its novel interacting partner Rab32 RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's disease The role of the LRRK2 gene in Parkinsonism Protein degradation pathways in Parkinson's disease: curse or blessing PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2.Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy.Lrrk2 localization in the primate basal ganglia and thalamus: a light and electron microscopic analysis in monkeys Recent advances in the genetics of Parkinson's disease.Role of LRRK2 kinase dysfunction in Parkinson disease Sequences located within the N-terminus of the PD-linked LRRK2 lead to increased aggregation and attenuation of 6-hydroxydopamine-induced cell death.Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo.LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice.The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling.Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning Cellular effects of LRRK2 mutations.Decoding Parkinson's Disease Pathogenesis: The Role of Deregulated mRNA Translation.Understanding the molecular basis of Parkinson's disease, identification of biomarkers and routes to therapy.Autophagic pathways in Parkinson disease and related disorders.Mechanisms of LRRK2-mediated neurodegeneration.Lysosome-dependent pathways as a unifying theme in Parkinson's disease.Human leucine-rich repeat kinase 1 and 2: intersecting or unrelated functions?A link between LRRK2, autophagy and NAADP-mediated endolysosomal calcium signalling.Prediction of the repeat domain structures and impact of parkinsonism-associated variations on structure and function of all functional domains of leucine-rich repeat kinase 2 (LRRK2).The role of autophagy in Crohn's disease.LRRK2, a puzzling protein: insights into Parkinson's disease pathogenesis Genes associated with Parkinson's disease: regulation of autophagy and beyond.LRRK2 at the Crossroad Between Autophagy and Microtubule Trafficking: Insights into Parkinson's Disease.The G2019S LRRK2 mutation increases myeloid cell chemotactic responses and enhances LRRK2 binding to actin-regulatory proteins.A Link between Autophagy and the Pathophysiology of LRRK2 in Parkinson's Disease.Surfactant secretion in LRRK2 knock-out rats: changes in lamellar body morphology and rate of exocytosis.LRRK2 secretion in exosomes is regulated by 14-3-3.Connecting Ca2+ and lysosomes to Parkinson disease.Convergent pathways in Parkinson's disease.Human R1441C LRRK2 regulates the synaptic vesicle proteome and phosphoproteome in a Drosophila model of Parkinson's disease.Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression.Linking Neuroinflammation and Neurodegeneration in Parkinson's Disease.

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Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease.

http://www.wikidata.org/entity/Q37402225

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on September 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Abnormal localization of leuci ...... partment in lewy body disease.

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Abnormal localization of leuci ...... partment in lewy body disease.

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type

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Abnormal localization of leuci ...... partment in lewy body disease.

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Abnormal localization of leuci ...... partment in lewy body disease.

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prefLabel

Abnormal localization of leuci ...... partment in lewy body disease.

@en

Abnormal localization of leuci ...... partment in lewy body disease.

@nl

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NEN.0B013E3181B44ED8

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Journal of Neuropathology & Experimental Neurology

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Abnormal localization of leuci ...... partment in lewy body disease.

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Darren J Moore

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Eizo Iseki

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Hiroaki Hino

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Hirotake Uchikado

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Keiji Wada

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Kenji Kosaka

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Kiyoshi Sato

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Michiko Minegishi

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Omi Katsuse

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Piers C Emson

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P2860

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

Kinase activity of mutant LRRK2 mediates neuronal toxicity

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

The familial Parkinsonism gene LRRK2 regulates neurite process morphology

Localization of LRRK2 to membranous and vesicular structures in mammalian brain

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

LRRK2 regulates synaptic vesicle endocytosis

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

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994-1005

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9

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2009-09-01T00:00:00Z

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