Dual role for the methyltransferase G9a in the maintenance of beta-globin gene transcription in adult erythroid cells.
about
Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineagesH3K9 histone methyltransferase G9a-mediated transcriptional activation of p21UTX mediates demethylation of H3K27me3 at muscle-specific genes during myogenesisRegulation and function of the NFE2 transcription factor in hematopoietic and non-hematopoietic cellsNF-E2 p45 is important for establishing normal function of platelets.The H3K27me3 demethylase UTX in normal development and disease.USF and NF-E2 cooperate to regulate the recruitment and activity of RNA polymerase II in the beta-globin gene locus.A case study in cross-talk: the histone lysine methyltransferases G9a and GLP.Identification of a PRMT5-dependent repressor complex linked to silencing of human fetal globin gene expressionThe Arabidopsis Mediator CDK8 module genes CCT (MED12) and GCT (MED13) are global regulators of developmental phase transitions.Recognition of H3K9 methylation by GLP is required for efficient establishment of H3K9 methylation, rapid target gene repression, and mouse viability.The distinctive roles of erythroid specific activator GATA-1 and NF-E2 in transcription of the human fetal γ-globin genes.A distinct mechanism for coactivator versus corepressor function by histone methyltransferase G9a in transcriptional regulationA novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2.G9a is essential for EMT-mediated metastasis and maintenance of cancer stem cell-like characters in head and neck squamous cell carcinomaInhibition of G9a methyltransferase stimulates fetal hemoglobin production by facilitating LCR/γ-globin looping.Gene-specific patterns of coregulator requirements by estrogen receptor-α in breast cancer cells.EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression.Effect of BIX-01294 on H3K9me2 levels and the imprinted gene Snrpn in mouse embryonic fibroblast cells.A Role for Widely Interspaced Zinc Finger (WIZ) in Retention of the G9a Methyltransferase on Chromatin.Maintenance of gene silencing by the coordinate action of the H3K9 methyltransferase G9a/KMT1C and the H3K4 demethylase Jarid1a/KDM5AG9a functions as a molecular scaffold for assembly of transcriptional coactivators on a subset of glucocorticoid receptor target genes.Histone H3K9 methyltransferase G9a represses PPARγ expression and adipogenesis.G9a, a multipotent regulator of gene expression.Haploinsufficiency of KDM6A is associated with severe psychomotor retardation, global growth restriction, seizures and cleft palate.MPN patients harbor recurrent truncating mutations in transcription factor NF-E2Chromatin looping as a target for altering erythroid gene expressionTranscription factor nuclear factor erythroid-2 mediates expression of the cytokine interleukin 8, a known predictor of inferior outcome in patients with myeloproliferative neoplasms.Functional and mechanistic diversity of distal transcription enhancers.Wiz binds active promoters and CTCF-binding sites and is required for normal behaviour in the mouse.G9a promotes proliferation and inhibits cell cycle exit during myogenic differentiation.Transcriptional environment and chromatin architecture interplay dictates globin expression patterns of heterospecific hybrids derived from undifferentiated human embryonic stem cells or from their erythroid progeny.The Lysine Methyltransferase G9a in Immune Cell Differentiation and Function.Histone demethylases in chromatin cross-talks.The expanding role of the Ehmt2/G9a complex in neurodevelopment.Identification of an NKX3.1-G9a-UTY transcriptional regulatory network that controls prostate differentiation.Activating and inhibitory functions for the histone lysine methyltransferase G9a in T helper cell differentiation and function.G9a/GLP-dependent histone H3K9me2 patterning during human hematopoietic stem cell lineage commitment.Pharmacologic control of chromatin looping.Recent progress in understanding and manipulating haemoglobin switching for the haemoglobinopathies.
P2860
Q24319742-977BCC0B-473B-4C19-8D8C-7780D9F9E817Q24329138-9F3BC3DD-54CE-49AB-A145-962F90DEF864Q28587655-1BC61EA1-077D-44B4-8615-89A54CECFD30Q29037128-52269225-9EB6-4D8A-B33C-241F64089653Q33407515-2859CD02-2797-4CD8-9442-786B31AE55EFQ33779153-E3DEC47F-926D-4B5D-BF69-F95D3E68F0CAQ33855140-E2BB04D4-7631-4EE4-AB84-CA628F05044EQ33922397-154F9B06-4BDD-44CD-AA37-473DBEAB3BE4Q34124980-B50724FA-BB45-4296-A861-0914AB506148Q34999378-9CC46638-9D5A-425B-8281-BC0648627BDEQ35104153-1855EDD9-2377-4FDB-B848-985E524D2E24Q35198410-2F8D3E65-B2CD-4E09-A061-84ECC401D778Q35604959-355A9956-4278-4835-8165-41D9DFD5D451Q35679582-E0558AD5-223B-4F58-9631-EF5E0A455616Q35740098-AC3470BC-2239-4ECE-83F0-85887ABD62E7Q35904956-12E9C682-8F1D-4C49-AEE4-2E15FE912F30Q35970098-879A329C-A41D-49DC-8E34-FB9B50260EDBQ36169265-6FC1F7D5-716F-434C-9D74-C28D8CFA8971Q36185202-AF1EE139-2F11-48FC-9FCF-8DA4820368B7Q36283537-2F3E7912-D0CE-46F0-A05E-129B404166CCQ36414731-D26ECED3-64D2-4EF7-8B5A-0F13F93B6642Q36438394-8A5E872D-F8A4-45BC-A0A3-EF768BFCA450Q36533638-FFF6A298-7B56-48E4-BB37-3F324A692809Q36548033-4F5936BF-2D6C-412C-AC27-93EB85B84969Q36770275-7ADD10E7-566E-476B-917E-24C4760651D8Q36822717-130DAE08-F62D-497A-AF49-146584190709Q36909398-1280222D-6F9F-4BCE-AA86-231E908C9268Q36967127-7F03877C-4526-4D07-B9FF-3F0A13EE2907Q37091409-6B02A731-4582-4406-AE68-45880C2FD6C2Q37159011-EC7EF823-7761-41C2-918A-53E1A7387913Q37294785-B9DDAAC0-9B66-4C83-A8C5-0C0A237FB664Q37333153-E76F7682-DA3C-45DF-A19C-C509852811E6Q37747182-C958EEBE-4046-4146-9110-C008C4F14EBFQ37898723-724A71E0-29E8-45BD-9ED8-EE5964ACAEF3Q38735095-F70A0A67-BBC8-445A-ABD8-1151ED8E73B4Q38762535-10CF6083-ABF1-4D8D-BB99-5D8B9A440B54Q40463701-DA54E427-385B-4152-A87B-5339A97DE30AQ42351641-1163EB20-B9CF-4A83-8A15-2848585570C8Q42408767-98FC9D19-1BF4-4836-B5FE-3C6247936F02Q45875308-EF02DFB6-D2A5-4A2E-9D8B-5D925B82CF05
P2860
Dual role for the methyltransferase G9a in the maintenance of beta-globin gene transcription in adult erythroid cells.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 12 October 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Dual role for the methyltransf ...... tion in adult erythroid cells.
@en
Dual role for the methyltransf ...... tion in adult erythroid cells.
@nl
type
label
Dual role for the methyltransf ...... tion in adult erythroid cells.
@en
Dual role for the methyltransf ...... tion in adult erythroid cells.
@nl
prefLabel
Dual role for the methyltransf ...... tion in adult erythroid cells.
@en
Dual role for the methyltransf ...... tion in adult erythroid cells.
@nl
P2093
P2860
P356
P1476
Dual role for the methyltransf ...... tion in adult erythroid cells.
@en
P2093
Alison M Hosey
Carmen Palii
Carolina Perez-Iratxeta
Chandra-Prakash Chaturvedi
F Jeffrey Dilworth
Jeffrey A Ranish
Marjorie Brand
Yoshihiro Nakatani
P2860
P304
18303-18308
P356
10.1073/PNAS.0906769106
P407
P577
2009-10-12T00:00:00Z