Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES) - Wikidata - awgldk - TriplyDB

Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES)

Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES)

http://www.wikidata.org/entity/Q39253539

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Targeting cellular metabolism to improve cancer therapeutics Mitochondria, cholesterol and cancer cell metabolism KRAS Mutant Pancreatic Cancer: No Lone Path to an Effective Treatment Dysregulated metabolism contributes to oncogenesis Coordination of nutrient availability and utilization by MAX- and MLX-centered transcription networks Rho GTPases and their roles in cancer metabolism Redox control of glutamine utilization in cancer Glutamine and cancer: cell biology, physiology, and clinical opportunities Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism Active Glutaminase C Self-assembles into a Supratetrameric Oligomer That Can Be Disrupted by an Allosteric Inhibitor Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism Chemical metabolic inhibitors for the treatment of blood-borne cancers Mechanistic Basis of Glutaminase Activation: A KEY ENZYME THAT PROMOTES GLUTAMINE METABOLISM IN CANCER CELLS Serial deletion reveals structural basis and stability for the core enzyme activity of human glutaminase 1 isoforms: relevance to excitotoxic neurodegeneration A novel glutaminase inhibitor-968 inhibits the migration and proliferation of non-small cell lung cancer cells by targeting EGFR/ERK signaling pathway.From Krebs to clinic: glutamine metabolism to cancer therapy.Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approaches Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism Glutaminolysis and Transferrin Regulate Ferroptosis.Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells.Inhibition of cancer cell proliferation by PPARγ is mediated by a metabolic switch that increases reactive oxygen species levels Mesenchymal phenotype predisposes lung cancer cells to impaired proliferation and redox stress in response to glutaminase inhibition Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells Simultaneously targeting tissue transglutaminase and kidney type glutaminase sensitizes cancer cells to acid toxicity and offers new opportunities for therapeutic intervention Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells.Small angle X-ray scattering studies of mitochondrial glutaminase C reveal extended flexible regions, and link oligomeric state with enzyme activity.Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth.Cancer metabolism: strategic diversion from targeting cancer drivers to targeting cancer suppliers MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism Effect of lysine to alanine mutations on the phosphate activation and BPTES inhibition of glutaminase The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.Vemurafenib resistance reprograms melanoma cells towards glutamine dependence.Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis.ErbB2 activation upregulates glutaminase 1 expression which promotes breast cancer cell proliferation Protein Kinase A Activation Promotes Cancer Cell Resistance to Glucose Starvation and Anoikis Proteomic and Metabolic Analyses of S49 Lymphoma Cells Reveal Novel Regulation of Mitochondria by cAMP and Protein Kinase A.Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia.Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition The Glutaminase-1 Inhibitor 968 Enhances Dihydroartemisinin-Mediated Antitumor Efficacy in Hepatocellular Carcinoma Cells

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P2860

Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES)

http://www.wikidata.org/entity/Q39253539

description

2007 nî lūn-bûn

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2007年の論文

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年學術文章

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2007年學術文章

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2007年學術文章

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name

Novel mechanism of inhibition ...... zol-2-yl)ethyl sulfide (BPTES)

@en

Novel mechanism of inhibition ...... ol-2-yl)ethyl sulfide (BPTES).

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type

label

Novel mechanism of inhibition ...... zol-2-yl)ethyl sulfide (BPTES)

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Novel mechanism of inhibition ...... ol-2-yl)ethyl sulfide (BPTES).

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prefLabel

Novel mechanism of inhibition ...... zol-2-yl)ethyl sulfide (BPTES)

@en

Novel mechanism of inhibition ...... ol-2-yl)ethyl sulfide (BPTES).

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Biochemical Journal

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Novel mechanism of inhibition ...... zol-2-yl)ethyl sulfide (BPTES)

@en

P2093

Camilo Rojas

http://www.w3.org/2001/XMLSchema#string

Jeffrey C Hansen

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Mary M Robinson

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Norman P Curthoys

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Sean K Hamilton

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Steven J McBryant

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Takashi Tsukamoto

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P2860

Cloning and analysis of unique human glutaminase isoforms generated by tissue-specific alternative splicing

Clinical experience with excitatory amino acid antagonist drugs

Mice lacking brain/kidney phosphate-activated glutaminase have impaired glutamatergic synaptic transmission, altered breathing, disorganized goal-directed behavior and die shortly after birth

Complexity and species variation of the kidney-type glutaminase gene.

Identification and interpretation of complexity in sedimentation velocity boundaries

Molecular cloning of a cDNA for rat hepatic glutaminase. Sequence similarity to kidney-type glutaminase.

Hepatic glutamine metabolism.

The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death.

Glutamate and the pathophysiology of hypoxic--ischemic brain damage.

Comparison of the hydrolytic and transfer activities of rat renal gamma-glutamyltranspeptidase.

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407-414

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10.1042/BJ20070039

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3

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406

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17581113

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2049044

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