Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1. - Wikidata - awgldk - TriplyDB

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

http://www.wikidata.org/entity/Q39659066

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A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b Thrombospondin 2 potentiates notch3/jagged1 signaling When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease Tau Protein Hyperphosphorylation and Aggregation in Alzheimer's Disease and Other Tauopathies, and Possible Neuroprotective Strategies γ-Secretase inhibitors and modulators.Toward the structure of presenilin/γ-secretase and presenilin homologs Structural biology of presenilin 1 complexes Complex regulation of γ-secretase: from obligatory to modulatory subunits Assembly, trafficking and function of gamma-secretase The canonical Notch signaling pathway: unfolding the activation mechanism.Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase.Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780.Asrij maintains the stem cell niche and controls differentiation during Drosophila lymph gland hematopoiesis.Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.Differential regulation of amyloid precursor protein/presenilin 1 interaction during Aβ40/42 [corrected] production detected using fusion constructs.Metalloprotease ADAM10 is required for Notch1 site 2 cleavage.Physiologic and pathologic events mediated by intramembranous and juxtamembranous proteolysis.An overview of notch signaling in adult tissue renewal and maintenance.Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane re Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein Notch Transmembrane Domain: Secondary Structure and Topology.The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous system.Chemical Biology, Molecular Mechanism and Clinical Perspective of γ-Secretase Modulators in Alzheimer's Disease Notch signaling and Notch signaling modifiers.Presenilin function and gamma-secretase activity.Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production.Protease inhibitors as potential disease-modifying therapeutics for Alzheimer's disease.Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1 The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloid Signal integration during development: mechanisms of EGFR and Notch pathway function and cross-talk.A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis A gamma-secretase inhibitor and quinacrine reduce prions and prevent dendritic degeneration in murine brains Signal peptide peptidases and gamma-secretase: cousins of the same protease family?Ero1L, a thiol oxidase, is required for Notch signaling through cysteine bridge formation of the Lin12-Notch repeats in Drosophila melanogaster.Notch1 hallmarks fibrillary depositions in sporadic Alzheimer's disease.Substrate specificity of gamma-secretase and other intramembrane proteases.

P2860

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P2860

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

http://www.wikidata.org/entity/Q39659066

description

2002 nî lūn-bûn

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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2002年论文

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2002年论文

@zh-cn

name

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

@en

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

@nl

type

label

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

@en

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

@nl

prefLabel

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

@en

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

@nl

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P1433

The EMBO Journal

P1476

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

@en

P2093

Akio Fukumori

http://www.w3.org/2001/XMLSchema#string

Harald Steiner

http://www.w3.org/2001/XMLSchema#string

Hisashi Tanii

http://www.w3.org/2001/XMLSchema#string

Masatoshi Takeda

http://www.w3.org/2001/XMLSchema#string

Takashi Kudo

http://www.w3.org/2001/XMLSchema#string

Takeshi Iwatsubo

http://www.w3.org/2001/XMLSchema#string

Toshihisa Tanaka

http://www.w3.org/2001/XMLSchema#string

P2860

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions.

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

Alzheimer's disease: genes, proteins, and therapy

Notch signaling: from the outside in

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

P304

5408-5416

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scholarly article

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10.1093/EMBOJ/CDF541

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P433

20

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P478

21

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Christian Haass

Masayasu Okochi

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2002-10-01T00:00:00Z

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P698

12374741

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129073

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