A role for the human DNA repair enzyme HAP1 in cellular protection against DNA damaging agents and hypoxic stress.
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SIRT1 deacetylates APE1 and regulates cellular base excision repairA functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimersAPE1 overexpression in XRCC1-deficient cells complements the defective repair of oxidative single strand breaks but increases genomic instabilityIsolation of a small molecule inhibitor of DNA base excision repair.Dynamic Regulation of APE1/Ref-1 as a Therapeutic Target ProteinSynthesis, characterization and solution structure of tethered oligonucleotides containing an internal 3'-phosphoglycolate, 5'-phosphate gapped lesionOverexpression of the human HAP1 protein sensitizes cells to the lethal effect of bioreductive drugsGenetic and biochemical characterization of human AP endonuclease 1 mutants deficient in nucleotide incision repair activityTranscriptional regulatory functions of mammalian AP-endonuclease (APE1/Ref-1), an essential multifunctional protein.The many functions of APE1/Ref-1: not only a DNA repair enzymeAn 'environment to nucleus' signaling system operates in B lymphocytes: redox status modulates BSAP/Pax-5 activation through Ref-1 nuclear translocation.Nuclear exclusion of transcription factors associated with apoptosis in developing nervous tissue.Human apurinic/apyrimidinic endonuclease (APE1) is a prognostic factor in ovarian, gastro-oesophageal and pancreatico-biliary cancers.Prognostic value of human apurinic/apyrimidinic endonuclease 1 (APE1) expression in breast cancer.Redox regulation of DNA repair: implications for human health and cancer therapeutic development.Overexpression of enzymes that repair endogenous damage to DNA.Identification and characterization of human apurinic/apyrimidinic endonuclease-1 inhibitorsAP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1Highly mutagenic exocyclic DNA adducts are substrates for the human nucleotide incision repair pathway.Killing effect of Ad5/F35-APE1 siRNA recombinant adenovirus in combination with hematoporphrphyrin derivative-mediated photodynamic therapy on human nonsmall cell lung cancerDevelopment and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell linesIdentification and quantification of DNA repair protein apurinic/apyrimidinic endonuclease 1 (APE1) in human cells by liquid chromatography/isotope-dilution tandem mass spectrometry.Uracil in duplex DNA is a substrate for the nucleotide incision repair pathway in human cells.Inhibition of APE1/Ref-1 redox activity rescues human retinal pigment epithelial cells from oxidative stress and reduces choroidal neovascularization.Nitric oxide controls nuclear export of APE1/Ref-1 through S-nitrosation of cysteines 93 and 310Age-related instability in spermatogenic cell nuclear and mitochondrial DNA obtained from Apex1 heterozygous mice.Levels of the DNA repair enzyme human apurinic/apyrimidinic endonuclease (APE1, APEX, Ref-1) are associated with the intrinsic radiosensitivity of cervical cancers.Psoralen-induced DNA adducts are substrates for the base excision repair pathway in human cellsDNA Repair and Cancer Therapy: Targeting APE1/Ref-1 Using Dietary AgentsHuman AP endonuclease 1 (HAP1) protein expression in breast cancer correlates with lymph node status and angiogenesisKnockdown of the DNA repair and redox signaling protein Ape1/Ref-1 blocks ovarian cancer cell and tumor growthCorrection of anaemia through the use of darbepoetin alfa improves chemotherapeutic outcome in a murine model of Lewis lung carcinoma.Evidence for base excision repair processing of DNA interstrand crosslinks.Suppression of oxidative phosphorylation in mouse embryonic fibroblast cells deficient in apurinic/apyrimidinic endonuclease.Role of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1Ape1/Ref-1 induces glial cell-derived neurotropic factor (GDNF) responsiveness by upregulating GDNF receptor alpha1 expressionDNA repair proteins as molecular targets for cancer therapeutics.Oxidative stress alters base excision repair pathway and increases apoptotic response in apurinic/apyrimidinic endonuclease 1/redox factor-1 haploinsufficient mice.Going ape as an approach to cancer therapeutics.Potent inhibition of human apurinic/apyrimidinic endonuclease 1 by arylstibonic acids.
P2860
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P2860
A role for the human DNA repair enzyme HAP1 in cellular protection against DNA damaging agents and hypoxic stress.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
A role for the human DNA repai ...... ing agents and hypoxic stress.
@en
type
label
A role for the human DNA repai ...... ing agents and hypoxic stress.
@en
prefLabel
A role for the human DNA repai ...... ing agents and hypoxic stress.
@en
P2093
P2860
P356
P1476
A role for the human DNA repai ...... ing agents and hypoxic stress.
@en
P2093
P2860
P304
P356
10.1093/NAR/22.23.4884
P577
1994-11-01T00:00:00Z