Parkin stabilizes microtubules through strong binding mediated by three independent domains.
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Neurodegeneration and microtubule dynamics: death by a thousand cutsMicrotubule-Binding Proteins as Promising Biomarkers of Paclitaxel Sensitivity in Cancer ChemotherapyRBR E3 ubiquitin ligases: new structures, new insights, new questionsMitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration.A Case for Microtubule Vulnerability in Amyotrophic Lateral Sclerosis: Altered Dynamics During DiseaseMorphological and bioenergetic demands underlying the mitophagy in post-mitotic neurons: the pink-parkin pathwayParkin occurs in a stable, non-covalent, approximately 110-kDa complex in brainMPTP and DSP-4 susceptibility of substantia nigra and locus coeruleus catecholaminergic neurons in mice is independent of parkin activity.Microtubule alterations occur early in experimental parkinsonism and the microtubule stabilizer epothilone D is neuroprotectiveA yeast two-hybrid screen reveals that osteopontin associates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain.Motor neuron synapse and axon defects in a C. elegans alpha-tubulin mutant.PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice.LRRK2 function on actin and microtubule dynamics in Parkinson diseaseMicrotubule destabilization is shared by genetic and idiopathic Parkinson's disease patient fibroblasts.Discovery of structural alterations in solid tumor oligodendroglioma by single molecule analysis.Parkin regulates kainate receptors by interacting with the GluK2 subunitBiochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity.Parkin mutations reduce the complexity of neuronal processes in iPSC-derived human neuronsDifferential programming of p53-deficient embryonic cells during rotenone block.Herpes simplex virus immediate-early protein ICP22 triggers loss of serine 2-phosphorylated RNA polymerase IIMitochondrial dynamics in cancer and neurodegenerative and neuroinflammatory diseases.Mitochondria: the next (neurode)generationNeurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson's Disease-Related LRRK2 G2019S Mutation.Microtubule: a common target for parkin and Parkinson's disease toxins.Parkin deficiency contributes to pancreatic tumorigenesis by inducing spindle multipolarity and misorientation.The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubulesMolecular pathways and genetic aspects of Parkinson's disease: from bench to bedside.Parkin protects dopaminergic neurons against microtubule-depolymerizing toxins by attenuating microtubule-associated protein kinase activationDirect binding with histone deacetylase 6 mediates the reversible recruitment of parkin to the centrosome.The role of PTEN-induced kinase 1 in mitochondrial dysfunction and dynamics.Mitochondrial dynamics in Parkinson's disease.Back to the tubule: microtubule dynamics in Parkinson's disease.The role of parkin in familial and sporadic Parkinson's disease.Parkin, A Top Level Manager in the Cell's Sanitation Department.Cross-functional E3 ligases Parkin and C-terminus Hsp70-interacting protein in neurodegenerative disorders.The interplay of neuronal mitochondrial dynamics and bioenergetics: implications for Parkinson's diseaseMechanisms underlying synaptic vulnerability and degeneration in neurodegenerative disease.Integrating pathways of Parkinson's disease in a molecular interaction map.An emerging role of PARK2 in cancer.Microtubule-Targeting Agents Enter the Central Nervous System (CNS): Double-edged Swords for Treating CNS Injury and Disease.
P2860
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P2860
Parkin stabilizes microtubules through strong binding mediated by three independent domains.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Parkin stabilizes microtubules ...... by three independent domains.
@en
type
label
Parkin stabilizes microtubules ...... by three independent domains.
@en
prefLabel
Parkin stabilizes microtubules ...... by three independent domains.
@en
P2093
P2860
P356
P1476
Parkin stabilizes microtubules ...... by three independent domains.
@en
P2093
Jinghui Zhao
Mark D Sutton
Qian Jiang
P2860
P304
17154-17162
P356
10.1074/JBC.M500843200
P407
P577
2005-02-28T00:00:00Z