Lack of PTEN sequesters CHK1 and initiates genetic instability.
about
P90 RSK arranges Chk1 in the nucleus for monitoring of genomic integrity during cell proliferationChk1 phosphorylates the tumour suppressor Mig-6, regulating the activation of EGF signallingNovel control of S phase of the cell cycle by ubiquitin-conjugating enzyme H714-3-3gamma mediates Cdc25A proteolysis to block premature mitotic entry after DNA damageA clinical scoring system for selection of patients for PTEN mutation testing is proposed on the basis of a prospective study of 3042 probandsBRCAness: finding the Achilles heel in ovarian cancerSIRT6 in DNA repair, metabolism and ageingAKT/PKB signaling: navigating downstreamDNA damage response and prostate cancer: defects, regulation and therapeutic implicationsRoles of the PI3K/Akt pathway in Epstein-Barr virus-induced cancers and therapeutic implicationsDNA damage control: regulation and functions of checkpoint kinase 1A cell cycle regulatory network controlling NF-kappaB subunit activity and functionAberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing geneCheckpoint kinase 1 is essential for meiotic cell cycle regulation in mouse oocytesA secreted PTEN phosphatase that enters cells to alter signaling and survivalNuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifsOncogene-induced senescence is a DNA damage response triggered by DNA hyper-replicationCombined PDGFR and HDAC Inhibition Overcomes PTEN Disruption in ChordomaThe DNA-damage effector checkpoint kinase 1 is essential for chromosome segregation and cytokinesis.An overview of the role of cancer stem cells in spine tumors with a special focus on chordoma.Anti-tumor activity of olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, in cultured endometrial carcinoma cells.Akt/PKB suppresses DNA damage processing and checkpoint activation in late G2.A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy.PTEN is a negative regulator of mitotic checkpoint complex during the cell cycleTargeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy.Akt activation emulates Chk1 inhibition and Bcl2 overexpression and abrogates G2 cell cycle checkpoint by inhibiting BRCA1 fociDoes PTEN loss impair DNA double-strand break repair by homologous recombination?Targeting nonhomologous end-joining through epidermal growth factor receptor inhibition: rationale and strategies for radiosensitization.Role of AKT signaling in DNA repair and clinical response to cancer therapy.Akt: a double-edged sword in cell proliferation and genome stability.Genetically engineered mouse models of PI3K signaling in breast cancer.Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair.Novel functions of the phosphatase SHP2 in the DNA replication and damage checkpoints.An integrative analysis of cellular contexts, miRNAs and mRNAs reveals network clusters associated with antiestrogen-resistant breast cancer cells.Replication licensing and the DNA damage checkpoint.Multiple signal pathways in obesity-associated cancer.Histone methyltransferase EZH2 induces Akt-dependent genomic instability and BRCA1 inhibition in breast cancer.CREB is a novel nuclear target of PTEN phosphatase.Targeting the Akt/mTOR pathway in Brca1-deficient cancers.Inhibition of the PI3K/Akt/GSK3 pathway downstream of BCR/ABL, Jak2-V617F, or FLT3-ITD downregulates DNA damage-induced Chk1 activation as well as G2/M arrest and prominently enhances induction of apoptosis.
P2860
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P2860
Lack of PTEN sequesters CHK1 and initiates genetic instability.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Lack of PTEN sequesters CHK1 and initiates genetic instability.
@en
type
label
Lack of PTEN sequesters CHK1 and initiates genetic instability.
@en
prefLabel
Lack of PTEN sequesters CHK1 and initiates genetic instability.
@en
P2093
P1433
P1476
Lack of PTEN sequesters CHK1 and initiates genetic instability
@en
P2093
Hanina Hibshoosh
Helen Piwnica-Worms
Hong Shen Li
Janusz Puc
Lorenzo Memeo
Mahesh Mansukhani
Megan Keniry
Ramon Parsons
Sarah E M Meek
Tej K Pandita
P304
P356
10.1016/J.CCR.2005.01.009
P577
2005-02-01T00:00:00Z