Targeted disruption of Np95 gene renders murine embryonic stem cells hypersensitive to DNA damaging agents and DNA replication blocks. - Wikidata - awgldk - TriplyDB

Targeted disruption of Np95 gene renders murine embryonic stem cells hypersensitive to DNA damaging agents and DNA replication blocks.

Targeted disruption of Np95 gene renders murine embryonic stem cells hypersensitive to DNA damaging agents and DNA replication blocks.

http://www.wikidata.org/entity/Q40722198

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Recognition of multivalent histone states associated with heterochromatin by UHRF1 protein NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein UHRF1 plays a role in maintaining DNA methylation in mammalian cells Critical role of the ubiquitin ligase activity of UHRF1, a nuclear RING finger protein, in tumor cell growth.Np95 is a histone-binding protein endowed with ubiquitin ligase activity ICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cells Mechanisms of interstrand DNA crosslink repair and human disorders The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications The retinoblastoma gene and its product are targeted by ICBP90: a key mechanism in the G1/S transition during the cell cycle Poly(ADP-ribose) polymerase 1 (PARP1) associates with E3 ubiquitin-protein ligase UHRF1 and modulates UHRF1 biological functions Conservation and divergence of methylation patterning in plants and animals.UHRF1 is a genome caretaker that facilitates the DNA damage response to gamma-irradiation ORTH/VIM proteins that regulate DNA methylation are functional ubiquitin E3 ligases.DNA hypomethylation induces a DNA replication-associated cell cycle arrest to block hepatic outgrowth in uhrf1 mutant zebrafish embryos Uhrf2 is important for DNA damage response in vascular smooth muscle cells.VIM1, a methylcytosine-binding protein required for centromeric heterochromatinization.Liver growth in the embryo and during liver regeneration in zebrafish requires the cell cycle regulator, uhrf1 UHRF1 phosphorylation by cyclin A2/cyclin-dependent kinase 2 is required for zebrafish embryogenesis.Np95 is implicated in pericentromeric heterochromatin replication and in major satellite silencing A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choice UHRF1 contributes to DNA damage repair as a lesion recognition factor and nuclease scaffold.UHRF1 regulation of Dnmt1 is required for pre-gastrula zebrafish development.Limoniastrum guyonianum aqueous gall extract induces apoptosis in human cervical cancer cells involving p16 INK4A re-expression related to UHRF1 and DNMT1 down-regulation.Mammalian DNA methyltransferases: a structural perspective.Characterization of Np95 expression in mouse brain from embryo to adult: A novel marker for proliferating neural stem/precursor cells.Adenovirus-mediated expression of UHRF1 reduces the radiosensitivity of cervical cancer HeLa cells to gamma-irradiation Epigenetics, development, and cancer: zebrafish make their mark..Epigenetic drug discovery: targeting DNA methyltransferases.The role of methyl-binding proteins in chromatin organization and epigenome maintenance.DNA methylation and its basic function.Inhibiting UHRF1 expression enhances radiosensitivity in human esophageal squamous cell carcinoma.Clinicopathological analysis of UHRF1 expression in medulloblastoma tissues and its regulation on tumor cell proliferation.Quantitative phosphoproteome analysis of embryonic stem cell differentiation toward blood Genetic Studies on Mammalian DNA Methyltransferases.The nuclear protein UHRF2 is a direct target of the transcription factor E2F1 in the induction of apoptosis DNA damage regulates UHRF1 stability via the SCF(β-TrCP) E3 ligase.UHRF1 is a sensor for DNA interstrand crosslinks and recruits FANCD2 to initiate the Fanconi anemia pathway.Gene therapy with RNAi targeting UHRF1 driven by tumor-specific promoter inhibits tumor growth and enhances the sensitivity of chemotherapeutic drug in breast cancer in vitro and in vivo.UHRF1 depletion causes a G2/M arrest, activation of DNA damage response and apoptosis.

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P2860

Targeted disruption of Np95 gene renders murine embryonic stem cells hypersensitive to DNA damaging agents and DNA replication blocks.

http://www.wikidata.org/entity/Q40722198

description

2002 nî lūn-bûn

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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2002年论文

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2002年论文

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name

Targeted disruption of Np95 ge ...... ts and DNA replication blocks.

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type

label

Targeted disruption of Np95 ge ...... ts and DNA replication blocks.

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prefLabel

Targeted disruption of Np95 ge ...... ts and DNA replication blocks.

@en

P1433

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P1433

Journal of Biological Chemistry

P1476

Targeted disruption of Np95 ge ...... ts and DNA replication blocks.

@en

P2093

Akira Fujimori

http://www.w3.org/2001/XMLSchema#string

Eiko Kubo

http://www.w3.org/2001/XMLSchema#string

Kouichi Tatsumi

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Masahiro Muto

http://www.w3.org/2001/XMLSchema#string

Takayuki Kurihara

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Tamami Takabe

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Yasuyoshi Kanari

http://www.w3.org/2001/XMLSchema#string

P2860

Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21WAF1

cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange

Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA

Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair.

Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway.

Checkpoints: controls that ensure the order of cell cycle events

The DNA damage response: putting checkpoints in perspective

Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies

P304

34549-34555

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scholarly article

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10.1074/JBC.M205189200

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P407

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37

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P478

277

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P577

2002-06-25T00:00:00Z

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P698

12084726

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