Mutations in the S4 domain of a pacemaker channel alter its voltage dependence.
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Regulation of hyperpolarization-activated HCN channel gating and cAMP modulation due to interactions of COOH terminus and core transmembrane regionsThe VGL-Chanome: A Protein Superfamily Specialized for Electrical Signaling and Ionic HomeostasisA single histidine residue determines the pH sensitivity of the pacemaker channel HCN2.The carboxyl-terminal region of cyclic nucleotide-modulated channels is a gating ring, not a permeation path.The S4-S5 linker couples voltage sensing and activation of pacemaker channels.Helical secondary structure of the external S3-S4 linker of pacemaker (HCN) channels revealed by site-dependent perturbations of activation phenotype.The Role of HCN Channels on Membrane Excitability in the Nervous SystemVoltage sensor movement and cAMP binding allosterically regulate an inherently voltage-independent closed-open transition in HCN channels.S4 movement in a mammalian HCN channel.Changes in local S4 environment provide a voltage-sensing mechanism for mammalian hyperpolarization-activated HCN channels.The pacemaker current: from basics to the clinics.C terminus-mediated control of voltage and cAMP gating of hyperpolarization-activated cyclic nucleotide-gated channels.Integrated allosteric model of voltage gating of HCN channels.Pacemaker channels produce an instantaneous current.Niflumic acid alters gating of HCN2 pacemaker channels by interaction with the outer region of S4 voltage sensing domains.Voltage-sensing mechanism is conserved among ion channels gated by opposite voltages.Identification of a surface charged residue in the S3-S4 linker of the pacemaker (HCN) channel that influences activation gating.The role of pacemaker currents in neuropathic pain.HCN Channels: New Therapeutic Targets for Pain Treatment
P2860
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P2860
Mutations in the S4 domain of a pacemaker channel alter its voltage dependence.
description
2000 nî lūn-bûn
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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2000年论文
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name
Mutations in the S4 domain of a pacemaker channel alter its voltage dependence.
@en
type
label
Mutations in the S4 domain of a pacemaker channel alter its voltage dependence.
@en
prefLabel
Mutations in the S4 domain of a pacemaker channel alter its voltage dependence.
@en
P2093
P2860
P1433
P1476
Mutations in the S4 domain of a pacemaker channel alter its voltage dependence.
@en
P2093
P2860
P356
10.1016/S0014-5793(00)01837-8
P407
P577
2000-08-01T00:00:00Z