Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1.
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LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complexPhosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's diseaseNo dopamine cell loss or changes in cytoskeleton function in transgenic mice expressing physiological levels of wild type or G2019S mutant LRRK2 and in human fibroblastsLRRK2 inhibitors and their potential in the treatment of Parkinson's disease: current perspectivesBenchmarking substrate-based kinase activity inference using phosphoproteomic data.Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy.Lack of correlation between the kinase activity of LRRK2 harboring kinase-modifying mutations and its phosphorylation at Ser910, 935, and Ser955.Leucine-rich repeat kinase 2 modulates neuroinflammation and neurotoxicity in models of human immunodeficiency virus 1-associated neurocognitive disordersNeurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson's Disease-Related LRRK2 G2019S Mutation.Peptidomic Analysis of Rat Plasma: Proteolysis in Hemorrhagic ShockEffects of LRRK2 Inhibitors on Nigrostriatal Dopaminergic NeurotransmissionLRRK2, a puzzling protein: insights into Parkinson's disease pathogenesisCellular processes associated with LRRK2 function and dysfunctionLRRK2 Kinase Inhibition as a Therapeutic Strategy for Parkinson's Disease, Where Do We Stand?Targeting LRRK2 in Parkinson's disease: an update on recent developments.Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation.Selective LRRK2 kinase inhibition reduces phosphorylation of endogenous Rab10 and Rab12 in human peripheral mononuclear blood cells.Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice.LRRK2: dropping (kinase) inhibitions and seeking an (immune) response.Leucine-rich repeat kinase 2 positively regulates inflammation and down-regulates NF-κB p50 signaling in cultured microglia cells.Targeted kinase inhibition relieves slowness and tremor in a Drosophila model of LRRK2 Parkinson's disease.Set up of a protocol for rat plasma peptidomics in hemorrhagic shock model in presence of heparin.
P2860
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P2860
Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Phosphoproteomic evaluation of ...... target effects of LRRK-2-IN-1.
@en
Phosphoproteomic evaluation of ...... target effects of LRRK-2-IN-1.
@nl
type
label
Phosphoproteomic evaluation of ...... target effects of LRRK-2-IN-1.
@en
Phosphoproteomic evaluation of ...... target effects of LRRK-2-IN-1.
@nl
prefLabel
Phosphoproteomic evaluation of ...... target effects of LRRK-2-IN-1.
@en
Phosphoproteomic evaluation of ...... target effects of LRRK-2-IN-1.
@nl
P2093
P2860
P356
P1476
Phosphoproteomic evaluation of ...... target effects of LRRK-2-IN-1.
@en
P2093
Andres Hurtado-Lorenzo
Chuong Nguyen
Elie Needle
G Stephen Noell
Gregory C Luerman
Harry Samaroo
John Dunlop
Kieran F Geoghegan
Paul Galatsis
P2860
P304
P356
10.1111/JNC.12483
P407
P577
2013-11-11T00:00:00Z