Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells. - Wikidata - awgldk - TriplyDB

Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells.

Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells.

http://www.wikidata.org/entity/Q42271523

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Role for Msh5 in the regulation of Ig class switch recombination Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination DNA ligase IV syndrome; a review IgH class switching and translocations use a robust non-classical end-joining pathway The histone methyltransferase MMSET regulates class switch recombination The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination ATAD5 deficiency decreases B cell division and Igh recombination MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings A regulatory role for NBS1 in strand-specific mutagenesis during somatic hypermutation Extreme growth failure is a common presentation of ligase IV deficiency.Molecular characterization of hybridoma subclones spontaneously switching at high frequencies in vitro.The Mre11/Rad50/Nbs1 complex functions in resection-based DNA end joining in Xenopus laevis Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70 Origin of chromosomal translocations in lymphoid cancer.Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair.Cernunnos influences human immunoglobulin class switch recombination and may be associated with B cell lymphomagenesis A new type of radiosensitive T-B-NK+ severe combined immunodeficiency caused by a LIG4 mutation.The DSIF subunits Spt4 and Spt5 have distinct roles at various phases of immunoglobulin class switch recombination Pathway choice in DNA double strand break repair: observations of a balancing act.Mechanisms of double-strand break repair in somatic mammalian cells.Impaired induction of DNA lesions during immunoglobulin class-switch recombination in humans influences end-joining repair.APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination.Mechanism and regulation of class switch recombination Mismatch repair proteins MSH2, MLH1, and EXO1 are important for class-switch recombination events occurring in B cells that lack nonhomologous end joining.Choosing the right path: does DNA-PK help make the decision?Aberrant recombination and repair during immunoglobulin class switching in BRCA1-deficient human B cells An inherited immunoglobulin class-switch recombination deficiency associated with a defect in the INO80 chromatin remodeling complex.XRCC1 suppresses somatic hypermutation and promotes alternative nonhomologous end joining in Igh genes.Role of transgene regulation in ex vivo lentiviral correction of artemis deficiency Successful bone marrow transplantation in a patient with DNA ligase IV deficiency and bone marrow failure RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling A primary immunodeficiency characterized by defective immunoglobulin class switch recombination and impaired DNA repair.Role for DNA repair factor XRCC4 in immunoglobulin class switch recombination.DCLRE1C (ARTEMIS) mutations causing phenotypes ranging from atypical severe combined immunodeficiency to mere antibody deficiency.Fixing DNA breaks during class switch recombination.Regulation of AID, the B-cell genome mutator.Immunoglobulin class-switch recombination deficiencies.Ligase-4 Deficiency Causes Distinctive Immune Abnormalities in Asymptomatic Individuals.Class switch recombination efficiency and junction microhomology patterns in Msh2-, Mlh1-, and Exo1-deficient mice depend on the presence of mu switch region tandem repeats.

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P2860

Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells.

http://www.wikidata.org/entity/Q42271523

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P2093

Aleksi Lähdesmäki

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Andrew R Gennery

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Anne-Marie Jones

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Lennart Hammarström

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Richard A Gatti

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Wei Zhou

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P2860

Requirement for XRCC4 and DNA ligase IV in alignment-based gap filling for nonhomologous DNA end joining in vitro

Class-switch recombination: interplay of transcription, DNA deamination and DNA repair

A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching

Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient.

Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination.

Lucky breaks: analysis of recombination in Saccharomyces.

DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency.

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Michael R Ehrenstein

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8074713

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