The Rho family GTPase Cdc42 regulates the activation of Ras/MAP kinase by the exchange factor Ras-GRF.
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Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factorsDifferential actions of p60c-Src and Lck kinases on the Ras regulators p120-GAP and GDP/GTP exchange factor CDC25MmPhosphorylation of the Ras-GRF1 exchange factor at Ser916/898 reveals activation of Ras signaling in the cerebral cortexSpatial control of Cdc42 signalling by a GM130-RasGRF complex regulates polarity and tumorigenesisNeurotrophin-dependent tyrosine phosphorylation of Ras guanine-releasing factor 1 and associated neurite outgrowth is dependent on the HIKE domain of TrkA.Transcriptional profiling reveals functional links between RasGrf1 and Pttg1 in pancreatic beta cells.Physiologic properties and regulation of the actin cytoskeleton in vascular smooth muscleDefined spatiotemporal features of RAS-ERK signals dictate cell fate in MCF-7 mammary epithelial cells.Structural and spatial determinants regulating TC21 activation by RasGRF family nucleotide exchange factorsH-ras distribution and signaling in plasma membrane microdomains are regulated by acylation and deacylation events.The differential effects of wild-type and mutated K-Ras on MST2 signaling are determined by K-Ras activation kinetics.Ras subcellular localization defines extracellular signal-regulated kinase 1 and 2 substrate specificity through distinct utilization of scaffold proteinsFilamin A-mediated down-regulation of the exchange factor Ras-GRF1 correlates with decreased matrix metalloproteinase-9 expression in human melanoma cells.Distinct utilization of effectors and biological outcomes resulting from site-specific Ras activation: Ras functions in lipid rafts and Golgi complex are dispensable for proliferation and transformation.ERK1/2 MAP kinases promote cell cycle entry by rapid, kinase-independent disruption of retinoblastoma-lamin A complexes.Maintenance of CDC42 GDP-bound state by Rho-GDI inhibits MAP kinase activation by the exchange factor Ras-GRF. evidence for Ras-GRF function being inhibited by Cdc42-GDP but unaffected by CDC42-GTP.Differences on the inhibitory specificities of H-Ras, K-Ras, and N-Ras (N17) dominant negative mutants are related to their membrane microlocalization.RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation.Ras guanine nucleotide releasing factor 1 (RasGrf1) enhancement of Trk receptor-mediated neurite outgrowth requires activation of both H-Ras and Rac.Characterisation of HRas local signal transduction networks using engineered site-specific exchange factors.RAS at the Golgi antagonizes malignant transformation through PTPRκ-mediated inhibition of ERK activation
P2860
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P2860
The Rho family GTPase Cdc42 regulates the activation of Ras/MAP kinase by the exchange factor Ras-GRF.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
The Rho family GTPase Cdc42 re ...... y the exchange factor Ras-GRF.
@en
The Rho family GTPase Cdc42 re ...... y the exchange factor Ras-GRF.
@nl
type
label
The Rho family GTPase Cdc42 re ...... y the exchange factor Ras-GRF.
@en
The Rho family GTPase Cdc42 re ...... y the exchange factor Ras-GRF.
@nl
prefLabel
The Rho family GTPase Cdc42 re ...... y the exchange factor Ras-GRF.
@en
The Rho family GTPase Cdc42 re ...... y the exchange factor Ras-GRF.
@nl
P2093
P2860
P356
P1476
The Rho family GTPase Cdc42 re ...... y the exchange factor Ras-GRF.
@en
P2093
Aaronson DS
Arozarena I
Gutkind JS
Tenbaum SP
Teramoto H
P2860
P304
26441-26448
P356
10.1074/JBC.M002992200
P407
P577
2000-08-01T00:00:00Z