Overexpression of Pim-1 during progression of prostatic adenocarcinoma - Wikidata - awgldk - TriplyDB

Overexpression of Pim-1 during progression of prostatic adenocarcinoma

Overexpression of Pim-1 during progression of prostatic adenocarcinoma

http://www.wikidata.org/entity/Q42835555

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PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers Molecular alterations in prostate cancer as diagnostic, prognostic, and therapeutic targets Cell-permeable Carboxyl-terminal p27Kip1 Peptide Exhibits Anti-tumor Activity by Inhibiting Pim-1 Kinase Flexibility of the P-loop of Pim-1 kinase: observation of a novel conformation induced by interaction with an inhibitor A small-molecule inhibitor of PIM kinases as a potential treatment for urothelial carcinomas Targeting Pim kinases for cancer treatment: opportunities and challenges PIM1 kinase as a target for cancer therapy Conditional transgenic expression of PIM1 kinase in prostate induces inflammation-dependent neoplasia Characterization of HJ-PI01 as a novel Pim-2 inhibitor that induces apoptosis and autophagic cell death in triple-negative human breast cancer PIM-1 kinase expression in adipocytic neoplasms: diagnostic and biological implications.Pim1 promotes human prostate cancer cell tumorigenicity and c-MYC transcriptional activity.Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases.Androgen deprivation therapy has no effect on Pim-1 expression in a mouse model of prostate cancer.In vitro evaluation of dihydropyridine-3-carbonitriles as potential cytotoxic agents through PIM-1 protein kinase inhibition.ERG deregulation induces PIM1 over-expression and aneuploidy in prostate epithelial cells.Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia.Targeting PIM kinase enhances the activity of sunitinib in renal cell carcinoma.PIM kinase isoform specific regulation of MIG6 expression and EGFR signaling in prostate cancer cells Inhibition of Pim1 kinase activation attenuates allergen-induced airway hyperresponsiveness and inflammation Differential regulation of androgen receptor by PIM-1 kinases via phosphorylation-dependent recruitment of distinct ubiquitin E3 ligases.Pim Kinase Interacts with Nonstructural 5A Protein and Regulates Hepatitis C Virus Entry.Functional role and therapeutic potential of the pim-1 kinase in colon carcinoma.PIM-1-specific mAb suppresses human and mouse tumor growth by decreasing PIM-1 levels, reducing Akt phosphorylation, and activating apoptosis.Identification of tumor-associated autoantigens for the diagnosis of colorectal cancer in serum using high density protein microarrays.Pim-3 is a Critical Risk Factor in Development and Prognosis of Prostate Cancer.Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells.Therapeutic Approaches Targeting MYC-Driven Prostate Cancer Why target PIM1 for cancer diagnosis and treatment?From oncoproteins/tumor suppressors to microRNAs, the newest therapeutic targets for pulmonary arterial hypertension.Pim kinases in hematological malignancies: where are we now and where are we going?PIM kinase (and Akt) biology and signaling in tumors.Loss of PIM2 enhances the anti-proliferative effect of the pan-PIM kinase inhibitor AZD1208 in non-Hodgkin lymphomas.Regulation of prostate stromal fibroblasts by the PIM1 protein kinase.Discovery and identification of PIM-1 kinase inhibitors through a hybrid screening approach.Phosphorylation of the androgen receptor by PIM1 in hormone refractory prostate cancer Transcription and translation are primary targets of Pim kinase inhibitor SGI-1776 in mantle cell lymphoma.Spectrum of T-lymphocyte activities regulating allergic lung inflammation.Pim kinase inhibitors sensitize prostate cancer cells to apoptosis triggered by Bcl-2 family inhibitor ABT-737.Clinical and therapeutic relevance of PIM1 kinase in gastric cancer.p53-dependent induction of prostate cancer cell senescence by the PIM1 protein kinase

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Overexpression of Pim-1 during progression of prostatic adenocarcinoma

http://www.wikidata.org/entity/Q42835555

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name

Overexpression of Pim-1 during progression of prostatic adenocarcinoma

@en

Overexpression of Pim-1 during progression of prostatic adenocarcinoma

@nl

type

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Overexpression of Pim-1 during progression of prostatic adenocarcinoma

@en

Overexpression of Pim-1 during progression of prostatic adenocarcinoma

@nl

prefLabel

Overexpression of Pim-1 during progression of prostatic adenocarcinoma

@en

Overexpression of Pim-1 during progression of prostatic adenocarcinoma

@nl

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JCP.2005.027672

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Journal of Clinical Pathology

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Overexpression of Pim-1 during progression of prostatic adenocarcinoma

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J N Eble

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L Ann Baldridge

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L Cheng

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L Li

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S R Malott

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T D Jones

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T L Cibull

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Y Luo

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The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG

Identification of the human pim-1 gene product as a 33-kilodalton cytoplasmic protein with tyrosine kinase activity

Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway

Cutting edge: Transcriptional activity of NFATc1 is enhanced by the Pim-1 kinase

Pim-1 kinase and p100 cooperate to enhance c-Myb activity

Characterization of the human PIM-1 gene: a putative proto-oncogene coding for a tissue specific member of the protein kinase family

Delineation of prognostic biomarkers in prostate cancer

Pim-1: a serine/threonine kinase with a role in cell survival, proliferation, differentiation and tumorigenesis.

Expression of E-cadherin in primary and metastatic prostate cancer.

Evidence of independent origin of multiple tumors from patients with prostate cancer.

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