The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process.
about
Internal IgH class switch region deletions are position-independent and enhanced by AID expressionEndonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regionsAlternative induction of meiotic recombination from single-base lesions of DNA deaminasesHepatitis C virus E2-CD81 interaction induces hypermutation of the immunoglobulin gene in B cells.Class switching and Myc translocation: how does DNA break?DNA-dependent protein kinase inhibits AID-induced antibody gene conversion.The whole-organism heavy chain B cell repertoire from Zebrafish self-organizes into distinct network featuresInduction of homologous recombination between sequence repeats by the activation induced cytidine deaminase (AID) proteinInduction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota.Msh6 protects mature B cells from lymphoma by preserving genomic stability.Targeting of somatic hypermutation.AID and mismatch repair in antibody diversification.AID to overcome the limitations of genomic information by introducing somatic DNA alterations.Accessibility control and machinery of immunoglobulin class switch recombination.Class-switch recombination: after the dawn of AID.Hyper-IgM syndrome type 4 with a B lymphocyte-intrinsic selective deficiency in Ig class-switch recombination.Lupus-prone MRL/faslpr/lpr mice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: concurrent upregulation of somatic hypermutation and class switch DNA recombination.What role for AID: mutator, or assembler of the immunoglobulin mutasome?The role of DNA breaks in genomic instability and tumorigenesis.Immunoglobulin somatic hypermutation: double-strand DNA breaks, AID and error-prone DNA repair.The role of the non-homologous end-joining pathway in lymphocyte development.V(H) replacement in rearranged immunoglobulin genes.Inhibition of the catalytic function of activation-induced cytidine deaminase promotes apoptosis of germinal center B cells in BXD2 mice.AID to overcome the limitations of genomic information.Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells.A role for the MutL mismatch repair Mlh3 protein in immunoglobulin class switch DNA recombination and somatic hypermutation.Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation.A role for AID in chromosome translocations between c-myc and the IgH variable region.The function of AID in somatic mutation and class switch recombination: upstream or downstream of DNA breaks.DNA damage: a trigger of innate immunity but a requirement for adaptive immune homeostasis.DNA repair in antibody somatic hypermutation.PARP activation promotes nuclear AID accumulation in lymphoma cellsE2A acts in cis in G1 phase of cell cycle to promote Ig gene diversification.A DNA break- and phosphorylation-dependent positive feedback loop promotes immunoglobulin class-switch recombination.NHEJ-deficient DT40 cells have increased levels of immunoglobulin gene conversion: evidence for a double strand break intermediate.Decoupling of normal CD40/interleukin-4 immunoglobulin heavy chain switch signal leads to genomic instability in SGH-MM5 and RPMI 8226 multiple myeloma cell lines.Overexpression of human DNA polymerase mu (Pol mu) in a Burkitt's lymphoma cell line affects the somatic hypermutation rate.Activation-induced cytosine deaminase (AID) is actively exported out of the nucleus but retained by the induction of DNA breaks.Activation-induced cytidine deaminase expression in follicular lymphoma: association between AID expression and ongoing mutation in FL.AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line.
P2860
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P2860
The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
The activation-induced deamina ...... somatic hypermutation process.
@en
The activation-induced deamina ...... somatic hypermutation process.
@nl
type
label
The activation-induced deamina ...... somatic hypermutation process.
@en
The activation-induced deamina ...... somatic hypermutation process.
@nl
prefLabel
The activation-induced deamina ...... somatic hypermutation process.
@en
The activation-induced deamina ...... somatic hypermutation process.
@nl
P2860
P356
P1476
The activation-induced deamina ...... somatic hypermutation process.
@en
P2093
David G Schatz
F Nina Papavasiliou
P2860
P304
P356
10.1084/JEM.20011858
P407
P577
2002-05-01T00:00:00Z