Substitution on the A-ring confers to bryopyran analogues the unique biological activity characteristic of bryostatins and distinct from that of the phorbol esters.
about
Molecular modeling, total synthesis, and biological evaluations of C9-deoxy bryostatin 1Total synthesis of bryostatin 7 via C-C bond-forming hydrogenationCapturing Biological Activity in Natural Product Fragments by Chemical SynthesisMolecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes.Total synthesis of bryostatin 16 using a Pd-catalyzed diyne coupling as macrocyclization method and synthesis of C20-epi-bryostatin 7 as a potent anticancer agent.Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivityBryostatins: biological context and biotechnological prospects.Total synthesis of bryostatin 9Synthesis of seco-B-ring bryostatin analogue WN-1 via C-C bond-forming hydrogenation: critical contribution of the B-ring in determining bryostatin-like and phorbol 12-myristate 13-acetate-like properties.Synthesis of a des-B-ring bryostatin analogue leads to an unexpected ring expansion of the bryolactone coreTranslating Nature's Library: The Bryostatins and Function-Oriented SynthesisMarine antitumor drugs: status, shortfalls and strategies.Total synthesis of bryostatin 1The bryostatin 1 A-ring acetate is not the critical determinant for antagonism of phorbol ester-induced biological responses.The synthetic bryostatin analog Merle 23 dissects distinct mechanisms of bryostatin activity in the LNCaP human prostate cancer cell lineSome phorbol esters might partially resemble bryostatin 1 in their actions on LNCaP prostate cancer cells and U937 leukemia cellsComparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogs in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of action.Probing the biology of natural products: molecular editing by diverted total synthesis.The medicinal potential of promising marine macrolides with anticancer activity.Challenges to the development of bryostatin-type anticancer drugs based on the activation mechanism of protein kinase Cδ.Protein kinase C pharmacology: refining the toolbox.Synthesis and biological activities of simplified analogs of the natural PKC ligands, bryostatin-1 and aplysiatoxin.Structural insights into the interactions of phorbol ester and bryostatin complexed with protein kinase C: a comparative molecular dynamics simulation study.Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity.Evaluation of Chromane-Based Bryostatin Analogues Prepared via Hydrogen-Mediated C-C Bond Formation: Potency Does Not Confer Bryostatin-like Biology.Replacement of the Bryostatin A- and B-Pyran Rings With Phenyl Rings Leads to Loss of High Affinity Binding With PKC.Concise synthesis of the bryostatin A-ring via consecutive C-C bond forming transfer hydrogenations.Total synthesis of a 20-deoxybryostatin.Biological activity of the bryostatin analog Merle 23 on mouse epidermal cells and mouse skin.
P2860
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P2860
Substitution on the A-ring confers to bryopyran analogues the unique biological activity characteristic of bryostatins and distinct from that of the phorbol esters.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh-hant
name
Substitution on the A-ring con ...... om that of the phorbol esters.
@en
Substitution on the A-ring con ...... om that of the phorbol esters.
@nl
type
label
Substitution on the A-ring con ...... om that of the phorbol esters.
@en
Substitution on the A-ring con ...... om that of the phorbol esters.
@nl
prefLabel
Substitution on the A-ring con ...... om that of the phorbol esters.
@en
Substitution on the A-ring con ...... om that of the phorbol esters.
@nl
P2093
P2860
P356
P1433
P1476
Substitution on the A-ring con ...... om that of the phorbol esters.
@en
P2093
Anh P Truong
Dennie S Welch
Gary E Keck
Jeffrey C Stephens
Matthew B Kraft
Nancy E Lewin
Noemi Kedei
Peter M Blumberg
Yam B Poudel
P2860
P304
P356
10.1021/OL8027253
P407
P577
2009-02-01T00:00:00Z