Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity.
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Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos ArylpyrrolesStructural Plasticity of Malaria Dihydroorotate Dehydrogenase Allows Selective Binding of Diverse Chemical ScaffoldsNovel Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Anti-malarial Activity in the Mouse ModelKinetics and ligand-binding preferences of Mycobacterium tuberculosis thymidylate synthases, ThyA and ThyXDisruption of uridine homeostasis links liver pyrimidine metabolism to lipid accumulationTargeting purine and pyrimidine metabolism in human apicomplexan parasitesIdentification of inhibitors that dually target the new permeability pathway and dihydroorotate dehydrogenase in the blood stage of Plasmodium falciparumHigh-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.Babesia bovis dihydroorotate dehydrogenase (BboDHODH) is a novel molecular target of drug for bovine babesiosisAnalysis of flavin oxidation and electron-transfer inhibition in Plasmodium falciparum dihydroorotate dehydrogenase.Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy.Current therapeutics, their problems, and sulfur-containing-amino-acid metabolism as a novel target against infections by "amitochondriate" protozoan parasites.Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in miceVariation among Plasmodium falciparum strains in their reliance on mitochondrial electron transport chain functionInhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export.Novel tricyclic indeno[2,1-d]pyrimidines with dual antiangiogenic and cytotoxic activities as potent antitumor agents.Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenaseIonic liquid-functionalized magnetic nanostructures as an efficient catalyst for the synthesis of 6H-chromeno[4,3-b]quinolin-6-ones.Heterologous expression of plasmodial proteins for structural studies and functional annotation.Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial ActivityTriazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum.Recent highlights in antimalarial drug resistance and chemotherapy research.Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in miceNovel inhibitors of the Plasmodium falciparum electron transport chain.Inhibition of arenavirus by A3, a pyrimidine biosynthesis inhibitor.Targeting the mitochondrial electron transport chain of Plasmodium falciparum: new strategies towards the development of improved antimalarials for the elimination era.Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenaseHemozoin-free Plasmodium falciparum mitochondria for physiological and drug susceptibility studies.Crystallization and preliminary X-ray diffraction analysis of Leishmania major dihydroorotate dehydrogenase.De Novo Pyrimidine Biosynthesis Connects Cell Integrity to Amphotericin B Susceptibility in Cryptococcus neoformans.Detergent-dependent kinetics of truncated Plasmodium falciparum dihydroorotate dehydrogenase.Dihydroorotate Dehydrogenase: Knockdown Inhibits Cell Growth and Proliferation via Inducing Cell Cycle Arrest
P2860
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P2860
Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity.
@en
Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity.
@nl
type
label
Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity.
@en
Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity.
@nl
prefLabel
Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity.
@en
Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity.
@nl
P2093
P2860
P356
P1476
Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity
@en
P2093
Azizeh M Farajallah
Jeffrey Baldwin
Margaret A Phillips
Pradipsinh K Rathod
P2860
P304
41827-41834
P356
10.1074/JBC.M206854200
P407
P577
2002-08-19T00:00:00Z