Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex. - Wikidata - awgldk - TriplyDB

Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex.

Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex.

http://www.wikidata.org/entity/Q44255903

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An induced rebinding model of antigen discrimination Structure of a complex of the human alpha/beta T cell receptor (TCR) HA1.7, influenza hemagglutinin peptide, and major histocompatibility complex class II molecule, HLA-DR4 (DRA*0101 and DRB1*0401): insight into TCR cross-restriction and alloreactiv Quantitative challenges in understanding ligand discrimination by alphabeta T cells Identifying Individual T Cell Receptors of Optimal Avidity for Tumor Antigens Lower Affinity T Cells are Critical Components and Active Participants of the Immune Response To affinity and beyond: harnessing the T cell receptor for cancer immunotherapy T cell antigen recognition at the cell membrane T cell activity correlates with oligomeric peptide-major histocompatibility complex binding on T cell surface Structure of CD84 provides insight into SLAM family function Epitope-specific TCR repertoire diversity imparts no functional advantage on the CD8+ T cell response to cognate viral peptides Different Thermodynamic Binding Mechanisms and Peptide Fine Specificities Associated with a Panel of Structurally Similar High-Affinity T Cell Receptors † ‡T-cell antagonism by short half-life pMHC ligands can be mediated by an efficient trapping of T-cell polarization toward the APC An integrated stochastic model of "inside-out" integrin activation and selective T-lymphocyte recruitment.Photocrosslinkable pMHC monomers stain T cells specifically and cause ligand-bound TCRs to be 'preferentially' transported to the cSMAC.A role for rebinding in rapid and reliable T cell responses to antigen Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function.Relating TCR-peptide-MHC affinity to immunogenicity for the design of tumor vaccines Immune complex-induced enhancement of bacterial antigen presentation requires Fcgamma receptor III expression on dendritic cells.The Goldilocks model for TCR-too much attraction might not be best for vaccine design Attenuated T cell responses to a high-potency ligand in vivo.The impact of TCR-binding properties and antigen presentation format on T cell responsiveness.Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time.Perspectives for computer modeling in the study of T cell activation Dynamic equilibrium of B7-1 dimers and monomers differentially affects immunological synapse formation and T cell activation in response to TCR/CD28 stimulation.Fast on-rates allow short dwell time ligands to activate T cells.T cell receptor binding kinetics required for T cell activation depend on the density of cognate ligand on the antigen-presenting cell.Mathematical modeling of chimeric TCR triggering predicts the magnitude of target lysis and its impairment by TCR downmodulation Dissociation of peripheral T cell responses from thymocyte negative selection by weak agonists supports a spare receptor model of T cell activation.Antigen potency and maximal efficacy reveal a mechanism of efficient T cell activation.T cell avidity and tumor immunity: problems and solutions Considerations for combined immune checkpoint modulation and radiation treatment.Equilibrium thermodynamics of cell-cell adhesion mediated by multiple ligand-receptor pairs.Antigen decoding by T lymphocytes: from synapses to fate determination.Specific increase in potency via structure-based design of a TCR.ITAMs versus ITIMs: striking a balance during cell regulation.How and why does the immunological synapse form? Physical chemistry meets cell biology.T-cell regulation by CD28 and CTLA-4.Molecular flexibility can influence the stimulatory ability of receptor-ligand interactions at cell-cell junctions.A detailed mathematical model predicts that serial engagement of IgE-Fc epsilon RI complexes can enhance Syk activation in mast cells.An evolutionary and structural perspective on T cell antigen receptor function.

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Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex.

http://www.wikidata.org/entity/Q44255903

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Nature Immunology

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Doucey MA

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Goyarts EC

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Kalergis AM

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Luescher IF

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Nathenson SG

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Vegh Z

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P2860

A functional hot spot for antigen recognition in a superagonist TCR/MHC complex

The immunological synapse: a molecular machine controlling T cell activation

Fidelity of T cell activation through multistep T cell receptor zeta phosphorylation

In vitro evolution of a T cell receptor with high affinity for peptide/MHC.

Structural basis of T cell recognition.

Kinetic proofreading in T-cell receptor signal transduction.

On defining the rules for interactions between the T cell receptor and its ligand: a critical role for a specific amino acid residue of the T cell receptor beta chain

Breaking the affinity ceiling for antibodies and T cell receptors

Effects of complementarity determining region mutations on the affinity of an alpha/beta T cell receptor: measuring the energy associated with CD4/CD8 repertoire skewing

T cell affinity maturation by selective expansion during infection

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