ATP binding at human P2X1 receptors. Contribution of aromatic and basic amino acids revealed using mutagenesis and partial agonists.
about
Molecular and functional properties of P2X receptors--recent progress and persisting challengesCrystal structure of the ATP-gated P2X(4) ion channel in the closed stateExploring the ATP-binding site of P2X receptorsA histidine scan to probe the flexibility of the rat P2X2 receptor zinc-binding siteP2X receptors: dawn of the post-structure era.A putative extracellular salt bridge at the subunit interface contributes to the ion channel function of the ATP-gated P2X2 receptorCovalent modification of mutant rat P2X2 receptors with a thiol-reactive fluorophore allows channel activation by zinc or acidic pH without ATP.A C-terminal lysine that controls human P2X4 receptor desensitization.Multiple roles of the extracellular vestibule amino acid residues in the function of the rat P2X4 receptor.An intersubunit zinc binding site in rat P2X2 receptorsAgonist trapped in ATP-binding sites of the P2X2 receptor.Nonspecific cytotoxic cell antimicrobial protein (NCAMP-1): a novel alarmin ligand identified in zebrafish.Activation and regulation of purinergic P2X receptor channelsRoles of the lateral fenestration residues of the P2X₄ receptor that contribute to the channel function and the deactivation effect of ivermectinGating mechanism of a P2X4 receptor developed from normal mode analysis and molecular dynamics simulationsInvolvement of the cysteine-rich head domain in activation and desensitization of the P2X1 receptor.Cysteine substitution mutants give structural insight and identify ATP binding and activation sites at P2X receptors.Secondary structure and gating rearrangements of transmembrane segments in rat P2X4 receptor channels.Cysteine substitution mutagenesis and the effects of methanethiosulfonate reagents at P2X2 and P2X4 receptors support a core common mode of ATP action at P2X receptors.Intracellular ATP binding is required to activate the slowly activating K+ channel I(Ks)Structural and molecular modeling features of P2X receptors.New structure enlivens interest in P2X receptors.Structural insights into the nucleotide base specificity of P2X receptors.Structural interpretation of P2X receptor mutagenesis studies on drug actionHeteromeric assembly of P2X subunits.Key sites for P2X receptor function and multimerization: overview of mutagenesis studies on a structural basis.Roles of conserved ectodomain cysteines of the rat P2X4 purinoreceptor in agonist binding and channel gating.Cysteine scanning mutagenesis (residues Glu52-Gly96) of the human P2X1 receptor for ATP: mapping agonist binding and channel gatingHighly conserved tyrosine 37 stabilizes desensitized states and restricts calcium permeability of ATP-gated P2X3 receptor.Ectodomain lysines and suramin block of P2X1 receptors.Characterisation of ATP analogues to cross-link and label P2X receptorsRole of aromatic and charged ectodomain residues in the P2X(4) receptor functions.Participation of the Lys313-Ile333 sequence of the purinergic P2X4 receptor in agonist binding and transduction of signals to the channel gate.Contribution of transmembrane regions to ATP-gated P2X2 channel permeability dynamics.Molecular basis of selective antagonism of the P2X1 receptor for ATP by NF449 and suramin: contribution of basic amino acids in the cysteine-rich loop.Contribution of the region Glu181 to Val200 of the extracellular loop of the human P2X1 receptor to agonist binding and gating revealed using cysteine scanning mutagenesis.Alanine substitution scanning of pannexin1 reveals amino acid residues mediating ATP sensitivity.P2X receptor chimeras highlight roles of the amino terminus to partial agonist efficacy, the carboxyl terminus to recovery from desensitization, and independent regulation of channel transitionsAmino acid residues constituting the agonist binding site of the human P2X3 receptorDeciphering the regulation of P2X4 receptor channel gating by ivermectin using Markov models.
P2860
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P2860
ATP binding at human P2X1 receptors. Contribution of aromatic and basic amino acids revealed using mutagenesis and partial agonists.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
ATP binding at human P2X1 rece ...... agenesis and partial agonists.
@en
ATP binding at human P2X1 rece ...... agenesis and partial agonists.
@nl
type
label
ATP binding at human P2X1 rece ...... agenesis and partial agonists.
@en
ATP binding at human P2X1 rece ...... agenesis and partial agonists.
@nl
prefLabel
ATP binding at human P2X1 rece ...... agenesis and partial agonists.
@en
ATP binding at human P2X1 rece ...... agenesis and partial agonists.
@nl
P2860
P356
P1476
ATP binding at human P2X1 rece ...... agenesis and partial agonists.
@en
P2093
Jonathan A Roberts
Richard J Evans
P2860
P304
P356
10.1074/JBC.M308964200
P407
P577
2003-12-29T00:00:00Z