RAG-1 mutations that affect the target specificity of V(D)j recombination: a possible direct role of RAG-1 in site recognition.
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Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences.Functional analysis of coordinated cleavage in V(D)J recombination.Stimulation of V(D)J cleavage by high mobility group proteins.RAG-2 promotes heptamer occupancy by RAG-1 in the assembly of a V(D)J initiation complex.Detection of RAG protein-V(D)J recombination signal interactions near the site of DNA cleavage by UV cross-linking.A RAG1 and RAG2 tetramer complex is active in cleavage in V(D)J recombination.Mechanistic basis for coding end sequence effects in the initiation of V(D)J recombinationConditional RAG-1 mutants block the hairpin formation step of V(D)J recombination.A C-terminal region of RAG1 contacts the coding DNA during V(D)J recombination.The RAG proteins in V(D)J recombination: more than just a nuclease.Deletion of the RAG2 C terminus leads to impaired lymphoid development in miceNicking is asynchronous and stimulated by synapsis in 12/23 rule-regulated V(D)J cleavage.Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination.Requirements for DNA hairpin formation by RAG1/2Distinct DNA sequence and structure requirements for the two steps of V(D)J recombination signal cleavage.Regulation of V(D)J recombination by nucleosome positioning at recombination signal sequencesDNA sequence and structure requirements for cleavage of V(D)J recombination signal sequencesCryptic signals and the fidelity of V(D)J joining.Understanding how the V(D)J recombinase catalyzes transesterification: distinctions between DNA cleavage and transposition.A RAG1 mutation found in Omenn syndrome causes coding flank hypersensitivity: a novel mechanism for antigen receptor repertoire restrictionPrimordial emergence of the recombination activating gene 1 (RAG1): sequence of the complete shark gene indicates homology to microbial integrases.Genetic evidence that the RAG1 protein directly participates in V(D)J recombination through substrate recognitionRAG1 and RAG2 cooperate in specific binding to the recombination signal sequence in vitro.Characterization of T and B cell repertoire diversity in patients with RAG deficiencyA highly ordered structure in V(D)J recombination cleavage complexes is facilitated by HMG1.A complex of RAG-1 and RAG-2 proteins persists on DNA after single-strand cleavage at V(D)J recombination signal sequences.Structural insights into the mechanism of double strand break formation by Hermes, a hAT family eukaryotic DNA transposase
P2860
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P2860
RAG-1 mutations that affect the target specificity of V(D)j recombination: a possible direct role of RAG-1 in site recognition.
description
1995 nî lūn-bûn
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1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh
1995年学术文章
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1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
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1995年學術文章
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1995年學術文章
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name
RAG-1 mutations that affect the target specificity of V
@nl
RAG-1 mutations that affect th ...... of RAG-1 in site recognition.
@en
type
label
RAG-1 mutations that affect the target specificity of V
@nl
RAG-1 mutations that affect th ...... of RAG-1 in site recognition.
@en
prefLabel
RAG-1 mutations that affect the target specificity of V
@nl
RAG-1 mutations that affect th ...... of RAG-1 in site recognition.
@en
P2093
P356
P1433
P1476
RAG-1 mutations that affect th ...... e of RAG-1 in site recognition
@en
P2093
D C van Gent
P304
P356
10.1101/GAD.9.17.2193
P577
1995-09-01T00:00:00Z