Synergistic regulation of human beta-globin gene switching by locus control region elements HS3 and HS4.
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Distinct domains of erythroid Krüppel-like factor modulate chromatin remodeling and transactivation at the endogenous beta-globin gene promoterLocus control regionsThe human beta-globin locus control regionRescue of the embryonic lethal hematopoietic defect reveals a critical role for GATA-2 in urogenital developmentEffect of deletion of 5'HS3 or 5'HS2 of the human beta-globin locus control region on the developmental regulation of globin gene expression in beta-globin locus yeast artificial chromosome transgenic mice.A negative cis-element regulates the level of enhancement by hypersensitive site 2 of the beta-globin locus control region.Fine tuning of globin gene expression by DNA methylation.Mutation of a transcriptional motif of a distant regulatory element reduces the expression of embryonic and fetal globin genes.Requirements for utilization of CREB binding protein by hypersensitive site two of the beta-globin locus control regionAll of the human beta-type globin genes compete for LCR enhancer activity in embryonic erythroid cells of yeast artificial chromosome transgenic miceAdult stage gamma-globin silencing is mediated by a promoter direct repeat element.Developmental specificity of the interaction between the locus control region and embryonic or fetal globin genes in transgenic mice with an HS3 core deletionSubstitution of the human beta-spectrin promoter for the human agamma-globin promoter prevents silencing of a linked human beta-globin gene in transgenic miceDNase I hypersensitivity and epsilon-globin transcriptional enhancement are separable in locus control region (LCR) HS1 mutant human beta-globin YAC transgenic miceLocalization of distant urogenital system-, central nervous system-, and endocardium-specific transcriptional regulatory elements in the GATA-3 locus.Dividing the empire: boundary chromatin elements delimit the territory of enhancers.Synergistic and additive properties of the beta-globin locus control region (LCR) revealed by 5'HS3 deletion mutations: implication for LCR chromatin architecture.Activation of beta-major globin gene transcription is associated with recruitment of NF-E2 to the beta-globin LCR and gene promoter.Hypersensitive site 2 specifies a unique function within the human beta-globin locus control region to stimulate globin gene transcription.Enhancement of beta-globin locus control region-mediated transactivation by mitogen-activated protein kinases through stochastic and graded mechanismsSequences flanking hypersensitive sites of the beta-globin locus control region are required for synergistic enhancementEvolution of hemoglobin and its genesThe beta-globin locus control region versus gene therapy vectors: a struggle for expression.Cooperative activities of hematopoietic regulators recruit RNA polymerase II to a tissue-specific chromatin domain.Promoters of the murine embryonic beta-like globin genes Ey and betah1 do not compete for interaction with the beta-globin locus control region.Histone acetylation beyond promoters: long-range acetylation patterns in the chromatin world.Multiple interactions between regulatory regions are required to stabilize an active chromatin hub.Evaluation of beta-globin gene therapy constructs in single copy transgenic mice.The world according to MafBeta-globin locus control region HS2 and HS3 interact structurally and functionallySequences in the (A)gamma-delta intergenic region are not required for stage-specific regulation of the human beta-globin gene locusFurther understanding of the beta-globin locus regulation at the molecular level: looping or linking models?Plasticity of hematopoietic stem cells and cellular memory.Human beta-globin locus control region HS5 contains CTCF- and developmental stage-dependent enhancer-blocking activity in erythroid cells.Context-dependent EKLF responsiveness defines the developmental specificity of the human epsilon-globin gene in erythroid cells of YAC transgenic mice.The beta-globin promoter is important for recruitment of erythroid Krüppel-like factor to the locus control region in erythroid cellsStudying the recruitment of Sp1 to the beta-globin promoter with an in vivo method: protein position identification with nuclease tail (PIN*POINT)Deletion of the core region of 5' HS2 of the mouse beta-globin locus control region reveals a distinct effect in comparison with human beta-globin transgenesMutation of gene-proximal regulatory elements disrupts human epsilon-, gamma-, and beta-globin expression in yeast artificial chromosome transgenic miceThe hypersensitive sites of the murine β-globin locus control region act independently to affect nuclear localization and transcriptional elongation.
P2860
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P2860
Synergistic regulation of human beta-globin gene switching by locus control region elements HS3 and HS4.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh-hant
name
Synergistic regulation of huma ...... l region elements HS3 and HS4.
@en
Synergistic regulation of huma ...... l region elements HS3 and HS4.
@nl
type
label
Synergistic regulation of huma ...... l region elements HS3 and HS4.
@en
Synergistic regulation of huma ...... l region elements HS3 and HS4.
@nl
prefLabel
Synergistic regulation of huma ...... l region elements HS3 and HS4.
@en
Synergistic regulation of huma ...... l region elements HS3 and HS4.
@nl
P2093
P356
P1433
P1476
Synergistic regulation of huma ...... l region elements HS3 and HS4.
@en
P2093
P304
P356
10.1101/GAD.9.24.3083
P577
1995-12-01T00:00:00Z