about
Shelterin complexExtended And Processed Telomere End and Associated DNA Binding and Packaging Protein ComplexExtended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order StructureIncorporation Of Extended And Processed Telomere End Into Associated Protein StructureIncorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein StructureTelomere shortening during replicative exhaustion
P527
P688
HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitmentTPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomeraseThe POT1-TPP1 telomere complex is a telomerase processivity factorPTOP interacts with POT1 and regulates its localization to telomeresA critical role for TPP1 and TIN2 interaction in high-order telomeric complex assemblyPOT1 as a terminal transducer of TRF1 telomere length controlHuman POT1 facilitates telomere elongation by telomeraseTelosome, a mammalian telomere-associated complex formed by multiple telomeric proteinsPOT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substratesHuman POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro.Telomere protection by mammalian Pot1 requires interaction with Tpp1Characterization of the DNA binding specificity of Shelterin complexesHuman protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitroPOT1 and TRF2 cooperate to maintain telomeric integrityThe human CST complex is a terminator of telomerase activitySingle-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangsTelomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to TelomeresRECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenancePOT1 inhibits the efficiency but promotes the fidelity of nonhomologous end joining at non-telomeric DNA regions.
P921
Q24293211-8D897329-B40F-4A94-A41D-663C6D0B55F4Q24293589-CFAEBBF5-1C05-460B-966A-90BBD17EF028Q24293607-BD168920-536C-49EE-A8A4-406789535440Q24295162-42BF1466-A9A9-4B43-B6EE-2F0768B95276Q24298475-ED56FD76-868F-453B-A9C9-F2667DDDA2DAQ24302841-BD9B54B9-E1B1-4668-BA6A-3496891BCE16Q24303687-ED37EC96-7951-40F3-BF9F-83C594FB0E0CQ24304989-454704E4-40B3-4F68-B3DD-726FF046A8C8Q24308828-A15CE402-CD5F-4F98-9177-13D107F29E69Q24310177-D9F4F33A-7DFF-4118-816E-E4F8ED7F5625Q24319841-0038467E-25FA-4FF8-84DD-A1A06466EEACQ24323345-B96F1692-B52A-48CD-A6AE-EF2301E7B2C9Q24337394-5E8C60FC-2A01-40EE-9BA2-6334F3B39FEEQ24338505-F745CF0C-AFAF-45FC-B2B5-9D9A36843D0EQ24339504-B9EE84E2-E5B8-45CD-838F-563AAAE5B0C7Q28115535-AE1B8175-2E6C-4B71-8929-52D3FF863F5EQ28116259-8E3A94EB-56E9-4001-B981-D28B431C9DBBQ28117859-A1201A45-1ABE-4426-BF01-61354112EB63Q28771762-5D422A37-7C52-4D6B-BAC7-30F481343857Q47307969-127360B6-F0C9-4D64-8DC4-1DDE11819582
P921
description
humanes Protein
@de
mammalian protein found in Homo sapiens
@en
menselijk eiwit
@nl
protein
@id
protein
@sv
proteinë
@sq
protèin
@ace
protéine humaine
@fr
بروتين بشري
@ar
name
Protection of telomeres 1
@en
Protection of telomeres 1
@nl
type
label
Protection of telomeres 1
@en
Protection of telomeres 1
@nl
altLabel
POT1
@en
POT1-like telomere end-binding protein
@en
protection of telomeres 1 homolog
@en
protection of telomeres protein 1
@en
prefLabel
Protection of telomeres 1
@en
Protection of telomeres 1
@nl
P637
P638
P680
P681
P682
P705
P352
P31
P352
P527
P637
NP_001036059
XP_006715980
XP_011514308
XP_011514309
XP_016867431
P638
P680
P681
P682
P702
P703
P705
ENSP00000350249
ENSP00000377002
ENSP00000388921
ENSP00000397632
ENSP00000403088
ENSP00000416820
ENSP00000476290
ENSP00000476371
ENSP00000476506
ENSP00000476673