Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway. - Test2 - elhamkhani - TriplyDB

Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway.

Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway.

http://www.wikidata.org/entity/Q34116956

about

Short telomeres initiate telomere recombination in primary and tumor cells SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins Shelterin complex and associated factors at human telomeres Roles of RECQ helicases in recombination based DNA repair, genomic stability and aging Human premature aging, DNA repair and RecQ helicases Telomere shortening in human diseases Evidence that a RecQ helicase slows senescence by resolving recombining telomeres Zscan4 regulates telomere elongation and genomic stability in ES cells Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer Werner syndrome: Clinical features, pathogenesis and potential therapeutic interventions Cell proliferation in the presence of telomerase The Werner syndrome helicase/exonuclease processes mobile D-loops through branch migration and degradation POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination Association of BLM and BRCA1 during Telomere Maintenance in ALT Cells WRN loss induces switching of telomerase-independent mechanisms of telomere elongation The DNA structure and sequence preferences of WRN underlie its function in telomeric recombination events WRN regulates pathway choice between classical and alternative non-homologous end joining Unwinding protein complexes in ALTernative telomere maintenance.Mechanism and substrate specificity of telomeric protein POT1 stimulation of the Werner syndrome helicase Telomerase deficiency affects the formation of chromosomal translocations by homologous recombination in Saccharomyces cerevisiae.Replication protein A stimulates the Werner syndrome protein branch migration activity.FANCC suppresses short telomere-initiated telomere sister chromatid exchange Human RECQL1 participates in telomere maintenance Telomeres: protecting chromosomes against genome instability Fission yeast Pot1 and RecQ helicase are required for efficient chromosome segregation.Strand exchange of telomeric DNA catalyzed by the Werner syndrome protein (WRN) is specifically stimulated by TRF2 ATR contributes to telomere maintenance in human cells Telomeric protein TRF2 protects Holliday junctions with telomeric arms from displacement by the Werner syndrome helicase.G-quadruplex nucleic acids and human disease Hyper telomere recombination accelerates replicative senescence and may promote premature aging.Multiple Mechanisms Contribute To Telomere Maintenance.Regulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T-SCE and stabilization of DNA-PKcs.The pur protein family: genetic and structural features in development and disease.Telomeres, chromosome instability and cancer Depletion of Ku70/80 reduces the levels of extrachromosomal telomeric circles and inhibits proliferation of ALT cells.Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis.Modulation of telomeres in alternative lengthening of telomeres type I like human cells by the expression of werner protein and telomerase.DNA helicases involved in DNA repair and their roles in cancer Caenorhabditis elegans POT-2 telomere protein represses a mode of alternative lengthening of telomeres with normal telomere lengths

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P2860

Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway.

http://www.wikidata.org/entity/Q34116956

description

2005 nî lūn-bûn

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2005 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2005 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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Elevated telomere-telomere rec ...... engagement of the ALT pathway.

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Elevated telomere-telomere rec ...... engagement of the ALT pathway.

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Elevated telomere-telomere rec ...... engagement of the ALT pathway.

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Elevated telomere-telomere rec ...... engagement of the ALT pathway.

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Elevated telomere-telomere rec ...... engagement of the ALT pathway.

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Elevated telomere-telomere rec ...... engagement of the ALT pathway.

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Elevated telomere-telomere rec ...... engagement of the ALT pathway.

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Elevated telomere-telomere rec ...... engagement of the ALT pathway.

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Elevated telomere-telomere rec ...... engagement of the ALT pathway.

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Genes & Development

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Elevated telomere-telomere rec ...... engagement of the ALT pathway.

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Asha S Multani

http://www.w3.org/2001/XMLSchema#string

Charles Kingsley

http://www.w3.org/2001/XMLSchema#string

Jin Ma

http://www.w3.org/2001/XMLSchema#string

Ling Wu

http://www.w3.org/2001/XMLSchema#string

Michel Lebel

http://www.w3.org/2001/XMLSchema#string

Purnima R Laud

http://www.w3.org/2001/XMLSchema#string

Ronald A DePinho

http://www.w3.org/2001/XMLSchema#string

Sandy Chang

http://www.w3.org/2001/XMLSchema#string

Sen Pathak

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Susan M Bailey

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P2860

The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes

POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates

Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro.

The Werner syndrome protein is a DNA helicase

Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseases

Telomere maintenance requires the RAD51D recombination/repair protein

Preferential binding of a G-quadruplex ligand to human chromosome ends.

SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, suppresses genome instability and homeologous recombination.

The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2

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2560-2570

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scholarly article

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10.1101/GAD.1321305

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21

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19

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2005-11-01T00:00:00Z

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7503521

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16264192

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1276730

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