Phosphorylation and activation of Bub1 on unattached chromosomes facilitate the spindle checkpoint.
about
Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1Bub1 regulates chromosome segregation in a kinetochore-independent mannerMPS1-dependent mitotic BLM phosphorylation is important for chromosome stabilityLinking kinetochore-microtubule binding to the spindle checkpointBub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesisKinetochore function is controlled by a phospho-dependent coexpansion of inner and outer components.Structure and Substrate Recruitment of the Human Spindle Checkpoint Kinase Bub1Mad1 kinetochore recruitment by Mps1-mediated phosphorylation of Bub1 signals the spindle checkpoint.Bub1 autophosphorylation feeds back to regulate kinetochore docking and promote localized substrate phosphorylationThe function of a spindle checkpoint gene bub-1 in C. elegans development.Impaired Bub1 function in vivo compromises tension-dependent checkpoint function leading to aneuploidy and tumorigenesis.Mutual regulation between the spindle checkpoint and APC/C.Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression.Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524.Making an effective switch at the kinetochore by phosphorylation and dephosphorylation.Kinetochore targeting of fission yeast Mad and Bub proteins is essential for spindle checkpoint function but not for all chromosome segregation roles of Bub1p.Overcoming inhibition in the spindle checkpoint.BUB1 and BUBR1: multifaceted kinases of the cell cycle.Bub1 and BubR1: at the interface between chromosome attachment and the spindle checkpointMonitoring the fidelity of mitotic chromosome segregation by the spindle assembly checkpoint.Kinase signaling in the spindle checkpoint.The kinetochore protein Bub1 participates in the DNA damage response.A sequential multi-target Mps1 phosphorylation cascade promotes spindle checkpoint signaling.BRK1, a Bub1-related kinase, is essential for generating proper tension between homologous kinetochores at metaphase I of rice meiosis.Role of Hcn1 and its phosphorylation in fission yeast anaphase-promoting complex/cyclosome function.Kinase and Phosphatase Cross-Talk at the Kinetochore.
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Phosphorylation and activation of Bub1 on unattached chromosomes facilitate the spindle checkpoint.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 08 July 2004
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Phosphorylation and activation ...... litate the spindle checkpoint.
@en
Phosphorylation and activation ...... litate the spindle checkpoint.
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type
label
Phosphorylation and activation ...... litate the spindle checkpoint.
@en
Phosphorylation and activation ...... litate the spindle checkpoint.
@nl
prefLabel
Phosphorylation and activation ...... litate the spindle checkpoint.
@en
Phosphorylation and activation ...... litate the spindle checkpoint.
@nl
P2860
P356
P1433
P1476
Phosphorylation and activation ...... litate the spindle checkpoint.
@en
P2093
Rey-Huei Chen
P2860
P304
P356
10.1038/SJ.EMBOJ.7600308
P407
P577
2004-07-08T00:00:00Z