Conformational disturbance in Abl kinase upon mutation and deregulation. - Test2 - elhamkhani - TriplyDB

Conformational disturbance in Abl kinase upon mutation and deregulation.

Conformational disturbance in Abl kinase upon mutation and deregulation.

http://www.wikidata.org/entity/Q30485823

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Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors Mechanisms of drug resistance in kinases.Hydrogen exchange mass spectrometry: are we out of the quicksand?Allosteric interactions between the myristate- and ATP-site of the Abl kinase A yeast-based chemical screen identifies a PDE inhibitor that elevates steroidogenesis in mouse Leydig cells via PDE8 and PDE4 inhibition c-Abl Tyrosine Kinase Adopts Multiple Active Conformational States in Solution A Discovery Strategy for Selective Inhibitors of c-Src in Complex with the Focal Adhesion Kinase SH3/SH2-binding Region.Differential sensitivity of Src-family kinases to activation by SH3 domain displacement.Partial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometry.Enhanced SH3/linker interaction overcomes Abl kinase activation by gatekeeper and myristic acid binding pocket mutations and increases sensitivity to small molecule inhibitors Hierarchical modeling of activation mechanisms in the ABL and EGFR kinase domains: thermodynamic and mechanistic catalysts of kinase activation by cancer mutations.Hydrogen/deuterium exchange reveals distinct agonist/partial agonist receptor dynamics within vitamin D receptor/retinoid X receptor heterodimer Computational modeling of allosteric communication reveals organizing principles of mutation-induced signaling in ABL and EGFR kinases.The energy landscape analysis of cancer mutations in protein kinases Simultaneous reduction and digestion of proteins with disulfide bonds for hydrogen/deuterium exchange monitored by mass spectrometry.Affinity reagents that target a specific inactive form of protein kinases.Expression of a Src family kinase in chronic myelogenous leukemia cells induces resistance to imatinib in a kinase-dependent manner.Solvent accessibility of betaB2-crystallin and local structural changes due to deamidation at the dimer interface.Changes in signal transducer and activator of transcription 3 (STAT3) dynamics induced by complexation with pharmacological inhibitors of Src homology 2 (SH2) domain dimerization.Evidence for increased exposure of the Notch1 metalloprotease cleavage site upon conversion to an activated conformation DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex.Differential hydrogen/deuterium exchange mass spectrometry analysis of protein-ligand interactions Structure-guided optimization of small molecule c-Abl activators Pocketome: an encyclopedia of small-molecule binding sites in 4D Anchor-based classification and type-C inhibitors for tyrosine kinases.Structure and dynamic regulation of Abl kinases.Noncanonical role of the PDZ4 domain of the adaptor protein PDZK1 in the regulation of the hepatic high density lipoprotein receptor scavenger receptor class B, type I (SR-BI).Automated hydrogen/deuterium exchange electron transfer dissociation high resolution mass spectrometry measured at single-amide resolution.SH2 domains: modulators of nonreceptor tyrosine kinase activity.Biochemical mechanisms of resistance to small-molecule protein kinase inhibitors.Nitric oxide-induced conformational changes in soluble guanylate cyclase Advances in treatment of chronic myeloid leukemia with tyrosine kinase inhibitors: the evolving role of Bcr-Abl mutations and mutational analysis.HDX-MS takes centre stage at unravelling kinase dynamics.Advanced molecular dynamics simulation methods for kinase drug discovery.Choosing the best second-line tyrosine kinase inhibitor in imatinib-resistant chronic myeloid leukemia patients harboring Bcr-Abl kinase domain mutations: how reliable is the IC₅₀?Allosteric Communication Networks in Proteins Revealed through Pocket Crosstalk Analysis Electron transfer control in soluble methane monooxygenase.Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7.Detection of allosteric kinase inhibitors by displacement of active site probes.Interrogating the hidden phosphoproteome.

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P2860

Conformational disturbance in Abl kinase upon mutation and deregulation.

http://www.wikidata.org/entity/Q30485823

description

2009 nî lūn-bûn

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2009 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հունվարին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

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2009年論文

@zh-tw

2009年论文

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name

Conformational disturbance in Abl kinase upon mutation and deregulation.

@ast

Conformational disturbance in Abl kinase upon mutation and deregulation.

@en

type

label

Conformational disturbance in Abl kinase upon mutation and deregulation.

@ast

Conformational disturbance in Abl kinase upon mutation and deregulation.

@en

prefLabel

Conformational disturbance in Abl kinase upon mutation and deregulation.

@ast

Conformational disturbance in Abl kinase upon mutation and deregulation.

@en

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PNAS.0811912106

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Conformational disturbance in Abl kinase upon mutation and deregulation.

@en

P2093

Jianming Zhang

http://www.w3.org/2001/XMLSchema#string

Nathanael S Gray

http://www.w3.org/2001/XMLSchema#string

Roxana E Iacob

http://www.w3.org/2001/XMLSchema#string

Teodora Pene-Dumitrescu

http://www.w3.org/2001/XMLSchema#string

Thomas E Smithgall

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P2860

Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation

High-speed and high-resolution UPLC separation at zero degrees Celsius

Crystal structures of c-Src reveal features of its autoinhibitory mechanism

Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor

Structural basis for the autoinhibition of c-Abl tyrosine kinase

Crystal structure of the T315I Abl mutant in complex with the aurora kinases inhibitor PHA-739358

Activation of tyrosine kinases by mutation of the gatekeeper threonine

Three-dimensional structure of the tyrosine kinase c-Src

Crystal structure of the Src family tyrosine kinase Hck

Hydrogen exchange mass spectrometry for the analysis of protein dynamics

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