Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase
about
VHL type 2B mutations retain VBC complex form and functionCullin-RING ubiquitin ligases: global regulation and activation cyclesRING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitinationThe ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1BAR: An apoptosis regulator at the intersection of caspases and Bcl-2 family proteinsStem-loop binding protein, the protein that binds the 3' end of histone mRNA, is cell cycle regulated by both translational and posttranslational mechanismsTracheal development and the von Hippel-Lindau tumor suppressor homolog in DrosophilaThe RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complexInsights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complexUV-damaged DNA-binding proteins are targets of CUL-4A-mediated ubiquitination and degradationUbiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor proteinAPC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complexTIP120A associates with cullins and modulates ubiquitin ligase activityASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexesThe TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathwayStructural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHLCdc123 and checkpoint forkhead associated with RING proteins control the cell cycle by controlling eIF2gamma abundanceMammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase.SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) proteinMEX is a testis-specific E3 ubiquitin ligase that promotes death receptor-induced apoptosisE2-RING expansion of the NEDD8 cascade confers specificity to cullin modificationVHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligasesNARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF)Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7Analysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machinery.The p127 subunit (DDB1) of the UV-DNA damage repair binding protein is essential for the targeted degradation of STAT1 by the V protein of the paramyxovirus simian virus 5Ariadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteinsThe CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitinationNedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalphaSCFSkp2 complex targeted by Epstein-Barr virus essential nuclear antigenKeap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2HECT and RING finger families of E3 ubiquitin ligases at a glanceCdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34Systemic VHL gene functions and the VHL diseasevon Hippel-Lindau disease: a clinical and scientific reviewLigand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteinsIdentification of Ror2 as a hypoxia-inducible factor target in von Hippel-Lindau-associated renal cell carcinomaThe VHL tumor suppressor: master regulator of HIF
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P2860
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase
description
1999 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Science
@fr
artículu científicu espublizáu en 1999
@ast
im April 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1999/04/23)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/04/23)
@nl
наукова стаття, опублікована у квітні 1999
@uk
name
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase
@ast
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase
@en
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase
@nl
type
label
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase
@ast
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase
@en
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase
@nl
prefLabel
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase
@ast
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase
@en
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase
@nl
P2093
P3181
P1433
P1476
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase
@en
P2093
D. M. Koepp
D. Skowyra
J. W. Conaway
J. W. Harper
M. N. Conrad
O. Iliopoulos
R. C. Conaway
R. J. Moreland
S. J. Elledge
P304
P3181
P356
10.1126/SCIENCE.284.5414.657
P407
P577
1999-04-23T00:00:00Z