Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage - Test2 - elhamkhani - TriplyDB

Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage

Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage

http://www.wikidata.org/entity/Q31160033

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Centrosome-associated regulators of the G(2)/M checkpoint as targets for cancer therapy The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination DNA-PK-dependent RPA2 hyperphosphorylation facilitates DNA repair and suppresses sister chromatid exchange Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation The cohesin complex is required for the DNA damage-induced G2/M checkpoint in mammalian cells Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1 Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stress Targeting ATR and Chk1 kinases for cancer treatment: a new model for new (and old) drugs The replication fork: understanding the eukaryotic replication machinery and the challenges to genome duplication Claspin promotes normal replication fork rates in human cells The combined status of ATM and p53 link tumor development with therapeutic response Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation Targeting DNA Replication Stress for Cancer Therapy Roles of the PI3K/Akt pathway in Epstein-Barr virus-induced cancers and therapeutic implications Rad53-Mediated Regulation of Rrm3 and Pif1 DNA Helicases Contributes to Prevention of Aberrant Fork Transitions under Replication Stress.Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene Gli1 protein regulates the S-phase checkpoint in tumor cells via Bid protein, and its inhibition sensitizes to DNA topoisomerase 1 inhibitors Regulation of Claspin degradation by the ubiquitin-proteosome pathway during the cell cycle and in response to ATR-dependent checkpoint activation Spy1 expression prevents normal cellular responses to DNA damage: inhibition of apoptosis and checkpoint activation Novel regulation of checkpoint kinase 1: Is checkpoint kinase 1 a good candidate for anti-cancer therapy?Checkpoint kinase 1 in DNA damage response and cell cycle regulation The cancer therapeutic potential of Chk1 inhibitors: how mechanistic studies impact on clinical trial design Roles of Chk1 in cell biology and cancer therapy HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability DNA damage response genes and the development of cancer metastasis Toxic effect of silica nanoparticles on endothelial cells through DNA damage response via Chk1-dependent G2/M checkpoint Circumvention of Mcl-1-dependent drug resistance by simultaneous Chk1 and MEK1/2 inhibition in human multiple myeloma cells DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer The effect of the intra-S-phase checkpoint on origins of replication in human cells.The DNA-damage effector checkpoint kinase 1 is essential for chromosome segregation and cytokinesis.H2AX is required for cell cycle arrest via the p53/p21 pathway DNA damage-induced cell death is enhanced by progression through mitosis Centromere fragmentation is a common mitotic defect of S and G2 checkpoint override.Chk1 inhibition in p53-deficient cell lines drives rapid chromosome fragmentation followed by caspase-independent cell death RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint.Global regulation of genome duplication in eukaryotes: an overview from the epifluorescence microscope.Apoptosis induced by replication inhibitors in Chk1-depleted cells is dependent upon the helicase cofactor Cdc45.ATR and Chk1 suppress a caspase-3-dependent apoptotic response following DNA replication stress.Enhanced H2AX phosphorylation, DNA replication fork arrest, and cell death in the absence of Chk1.Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability.

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Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage

http://www.wikidata.org/entity/Q31160033

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2005 nî lūn-bûn

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2005 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2005 թվականի մայիսին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Inhibition of human Chk1 cause ...... ATR targets, and DNA breakage

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Inhibition of human Chk1 cause ...... ATR targets, and DNA breakage

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type

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Inhibition of human Chk1 cause ...... ATR targets, and DNA breakage

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Inhibition of human Chk1 cause ...... ATR targets, and DNA breakage

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prefLabel

Inhibition of human Chk1 cause ...... ATR targets, and DNA breakage

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Inhibition of human Chk1 cause ...... ATR targets, and DNA breakage

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MCB.25.9.3553-3562.2005

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Molecular and Cellular Biology

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Inhibition of human Chk1 cause ...... ATR targets, and DNA breakage

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Cecilia Lundin

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Claus Storgaard Sørensen

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Fredrik Johansson

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Lasse Tengbjerg Hansen

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Maxwell Sehested

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Randi G Syljuåsen

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P2860

A role for ATR in the DNA damage-induced phosphorylation of p53

Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints.

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

DNA synthesis at individual replication forks requires the essential initiation factor Cdc45p

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

Formation of a preinitiation complex by S-phase cyclin CDK-dependent loading of Cdc45p onto chromatin

Checkpoints: controls that ensure the order of cell cycle events

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9

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Thomas Helleday

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15831461

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phosphorylation

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1084285

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