Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.
about
NVP-LDE225, a potent and selective SMOOTHENED antagonist reduces melanoma growth in vitro and in vivoOxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cellsArsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effectorA small molecule that binds Hedgehog and blocks its signaling in human cellsSmall-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonistsAgonizing hedgehog.Roughing up Smoothened: chemical modulators of hedgehog signalingThe therapeutic potential of modulators of the Hedgehog-Gli signaling pathwayTargeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI InhibitorsThe Role of Hedgehog Signaling in Tumor Induced Bone DiseaseHedgehog Signaling in the Maintenance of Cancer Stem CellsCooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapyBasal cell carcinoma - molecular biology and potential new therapiesHedgehog signaling pathway and its targets for treatment in basal cell carcinomaNovel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation.Molecular pathways: novel approaches for improved therapeutic targeting of Hedgehog signaling in cancer stem cellsArsenic trioxide prevents osteosarcoma growth by inhibition of GLI transcription via DNA damage accumulationHedgehog signaling is critical for maintenance of the adult coronary vasculature in miceTargeting GLI1 expression in human inflammatory breast cancer cells enhances apoptosis and attenuates migration.Stem cell biology and drug discovery.Indian hedgehog signaling pathway: expression and regulation in pancreatic cancer.Gli-1 siRNA induced apoptosis in Huh7 cells.Converse conformational control of smoothened activity by structurally related small molecules.Recent patents for Hedgehog pathway inhibitors for the treatment of malignancy.Identification of Hedgehog signaling inhibitors with relevant human exposure by small molecule screening.Effects of inhibition of hedgehog signaling on cell growth and migration of uveal melanoma cells.Sustained Hedgehog signaling is required for basal cell carcinoma proliferation and survival: conditional skin tumorigenesis recapitulates the hair growth cycleNew hedgehog/GLI-signaling inhibitors from Adenium obesum.Targeting superficial or nodular Basal cell carcinoma with topically formulated small molecule inhibitor of smoothenedTargeting Hedgehog--a cancer stem cell pathwayRecent advances on skin-resident stem/progenitor cell functions in skin regeneration, aging and cancers and novel anti-aging and cancer therapies.Computational analysis of expression of human embryonic stem cell-associated signatures in tumors.Cleft lip and palate results from Hedgehog signaling antagonism in the mouse: Phenotypic characterization and clinical implicationsDose- and route-dependent teratogenicity, toxicity, and pharmacokinetic profiles of the hedgehog signaling antagonist cyclopamine in the mouse.Small-molecule modulators of the Sonic Hedgehog signaling pathway.Functional diversity of ESC-derived motor neuron subtypes revealed through intraspinal transplantation.Frequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies.Hedgehog and spinal cord injury.Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation.Hedgehog activity controls opening of the primary mouth.
P2860
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P2860
Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.
description
2003 nî lūn-bûn
@nan
2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Identification of a small mole ...... l cell carcinoma-like lesions.
@ast
Identification of a small mole ...... l cell carcinoma-like lesions.
@en
type
label
Identification of a small mole ...... l cell carcinoma-like lesions.
@ast
Identification of a small mole ...... l cell carcinoma-like lesions.
@en
prefLabel
Identification of a small mole ...... l cell carcinoma-like lesions.
@ast
Identification of a small mole ...... l cell carcinoma-like lesions.
@en
P2093
P2860
P356
P1476
Identification of a small mole ...... al cell carcinoma-like lesions
@en
P2093
Beatrice I Zaharian
Charlene Kon
Christine Gatchalian
Frank Y Wang
Hynek Wichterle
Jeffery A Porter
Juliet A Williams
Oivin M Guicherit
P2860
P304
P356
10.1073/PNAS.0732813100
P407
P50
P577
2003-04-04T00:00:00Z