CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase. - Test2 - elhamkhani - TriplyDB

CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase.

CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase.

http://www.wikidata.org/entity/Q34215301

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Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex.SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities The role and mechanism of CRL4 E3 ubiquitin ligase in cancer and its potential therapy implications Synthesis of lysine methyltransferase inhibitors PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription Regulation of Unperturbed DNA Replication by Ubiquitylation Sequential replication-coupled destruction at G1/S ensures genome stability.Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks CRL4-like Clr4 complex in Schizosaccharomyces pombe depends on an exposed surface of Dos1 for heterochromatin silencing Multivalent Interactions by the Set8 Histone Methyltransferase With Its Nucleosome Substrate The emerging role of lysine methyltransferase SETD8 in human diseases Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phase SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation CRL4Cdt2 E3 ubiquitin ligase and proliferating cell nuclear antigen (PCNA) cooperate to degrade thymine DNA glycosylase in S phase 14-3-3 proteins play a role in the cell cycle by shielding cdt2 from ubiquitin-mediated degradation Degradation of p12 subunit by CRL4Cdt2 E3 ligase inhibits fork progression after DNA damage.Regulation of TGF-β signaling, exit from the cell cycle, and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2.Efficient parvovirus replication requires CRL4Cdt2-targeted depletion of p21 to prevent its inhibitory interaction with PCNA CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration.Stress-stimulated mitogen-activated protein kinases control the stability and activity of the Cdt1 DNA replication licensing factor The SKP1-Cul1-F-box and leucine-rich repeat protein 4 (SCF-FbxL4) ubiquitin ligase regulates lysine demethylase 4A (KDM4A)/Jumonji domain-containing 2A (JMJD2A) protein.CRL4Cdt2: master coordinator of cell cycle progression and genome stability CUL4A overexpression as an independent adverse prognosticator in intrahepatic cholangiocarcinoma.The UBC9 E2 SUMO conjugating enzyme binds the PR-Set7 histone methyltransferase to facilitate target gene repression.MicroRNA binding site polymorphisms as biomarkers in cancer management and research.Thymine DNA glycosylase is a CRL4Cdt2 substrate.The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection.Role of β-catenin in post-meiotic male germ cell differentiation The stress phenotype makes cancer cells addicted to CDT2, a substrate receptor of the CRL4 ubiquitin ligase.Chromatin replication and epigenome maintenance.A role of tomato UV-damaged DNA binding protein 1 (DDB1) in organ size control via an epigenetic manner Checkpoint kinase ATR phosphorylates Cdt2, a substrate receptor of CRL4 ubiquitin ligase, and promotes the degradation of Cdt1 following UV irradiation.Proteome identification of proteins interacting with histone methyltransferase SET8.Histone H4 lysine 20 methylation: key player in epigenetic regulation of genomic integrity.Non-canonical CRL4A/4B(CDT2) interacts with RAD18 to modulate post replication repair and cell survival.Defining the replication program through the chromatin landscape CDK1-dependent inhibition of the E3 ubiquitin ligase CRL4CDT2 ensures robust transition from S Phase to Mitosis.Genetic variation in a microRNA-502 minding site in SET8 gene confers clinical outcome of non-small cell lung cancer in a Chinese population.Spontaneous development of hepatocellular carcinoma with cancer stem cell properties in PR-SET7-deficient livers.

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CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase.

http://www.wikidata.org/entity/Q34215301

description

2010 nî lūn-bûn

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2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2010 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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CRL4(Cdt2)-mediated destructio ...... romatin compaction in S phase.

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CRL4(Cdt2)-mediated destructio ...... romatin compaction in S phase.

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CRL4(Cdt2)-mediated destructio ...... romatin compaction in S phase.

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CRL4(Cdt2)-mediated destructio ...... romatin compaction in S phase.

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CRL4(Cdt2)-mediated destructio ...... romatin compaction in S phase.

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J.MOLCEL.2010.09.015

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CRL4(Cdt2)-mediated destructio ...... romatin compaction in S phase.

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Alice Tse

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Amity L Manning

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Courtney G Havens

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Jianping Jin

http://www.w3.org/2001/XMLSchema#string

Johannes C Walter

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Ju-Mei Li

http://www.w3.org/2001/XMLSchema#string

Lee Zou

http://www.w3.org/2001/XMLSchema#string

Nicholas J Dyson

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Rachel Litman Flynn

http://www.w3.org/2001/XMLSchema#string

Richard C Centore

http://www.w3.org/2001/XMLSchema#string

P2860

A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1

Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery

Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.

L3MBTL1, a histone-methylation-dependent chromatin lock

DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.

Modulation of p53 function by SET8-mediated methylation at lysine 382

PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression

Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes.

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

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10.1016/J.MOLCEL.2010.09.015

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1

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20932472

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