The first ATPase domain of the yeast 246-kDa protein is required for in vivo unwinding of the U4/U6 duplex.
about
Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosomeDistinct activities of the DExD/H-box splicing factor hUAP56 facilitate stepwise assembly of the spliceosomeProteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs.p68 RNA helicase is an essential human splicing factor that acts at the U1 snRNA-5' splice site duplex.The network of protein-protein interactions within the human U4/U6.U5 tri-snRNPPrediction of the archaeal exosome and its connections with the proteasome and the translation and transcription machineries by a comparative-genomic approachFunctional roles of DExD/H-box RNA helicases in Pre-mRNA splicingSki2-like RNA helicase structures: common themes and complex assembliesRNA helicases in splicingStructural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2Structural Basis of Brr2-Prp8 Interactions and Implications for U5 snRNP Biogenesis and the Spliceosome Active SiteInhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8A noncanonical PWI domain in the N-terminal helicase-associated region of the spliceosomal Brr2 proteinThe DExD/H-box ATPase Prp2p destabilizes and proofreads the catalytic RNA core of the spliceosome.Inhibition of a spliceosome turnover pathway suppresses splicing defects.Genetic analysis reveals a role for the C terminus of the Saccharomyces cerevisiae GTPase Snu114 during spliceosome activationCharacterization of U4 and U6 interactions with the 5' splice site using a S. cerevisiae in vitro trans-splicing systemThe 100-kda U5 snRNP protein (hPrp28p) contacts the 5' splice site through its ATPase siteSingle-Molecule Pull-Down FRET to Dissect the Mechanisms of Biomolecular MachinesMutations in spliceosomal proteins and retina degenerationA bird's-eye view of post-translational modifications in the spliceosome and their roles in spliceosome dynamicsDistinct domains of splicing factor Prp8 mediate different aspects of spliceosome activationTls1 regulates splicing of shelterin components to control telomeric heterochromatin assembly and telomere length.Dominant negative mutants of the yeast splicing factor Prp2 map to a putative cleft region in the helicase domain of DExD/H-box proteins.A novel missense SNRNP200 mutation associated with autosomal dominant retinitis pigmentosa in a Chinese family.Cell cycle abnormalities associated with differential perturbations of the human U5 snRNP associated U5-200kD RNA helicase.A conformational rearrangement in the spliceosome sets the stage for Prp22-dependent mRNA release.Brr2 plays a role in spliceosomal activation in addition to U4/U6 unwinding.Functional roles of protein splicing factors.The Ski2-family helicase Obelus regulates Crumbs alternative splicing and cell polarity.Brr2p-mediated conformational rearrangements in the spliceosome during activation and substrate repositioningSpliceosome activation: U4 is the path, stem I is the goal, and Prp8 is the keeper. Let's cheer for the ATPase Brr2!Retinitis Pigmentosa Mutations in Bad Response to Refrigeration 2 (Brr2) Impair ATPase and Helicase ActivitySubstrate-assisted mechanism of RNP disruption by the spliceosomal Brr2 RNA helicase.The EF-G-like GTPase Snu114p regulates spliceosome dynamics mediated by Brr2p, a DExD/H box ATPaseContribution of SNRNP200 sequence variations to retinitis pigmentosa.ATP-dependent unwinding of U4/U6 snRNAs by the Brr2 helicase requires the C terminus of Prp8.A role for ubiquitin in the spliceosome assembly pathway.Autosomal-dominant retinitis pigmentosa caused by a mutation in SNRNP200, a gene required for unwinding of U4/U6 snRNAs.Sad1 counteracts Brr2-mediated dissociation of U4/U6.U5 in tri-snRNP homeostasis.
P2860
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P2860
The first ATPase domain of the yeast 246-kDa protein is required for in vivo unwinding of the U4/U6 duplex.
description
1999 nî lūn-bûn
@nan
1999 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
The first ATPase domain of the ...... unwinding of the U4/U6 duplex.
@ast
The first ATPase domain of the ...... unwinding of the U4/U6 duplex.
@en
The first ATPase domain of the ...... unwinding of the U4/U6 duplex.
@nl
type
label
The first ATPase domain of the ...... unwinding of the U4/U6 duplex.
@ast
The first ATPase domain of the ...... unwinding of the U4/U6 duplex.
@en
The first ATPase domain of the ...... unwinding of the U4/U6 duplex.
@nl
prefLabel
The first ATPase domain of the ...... unwinding of the U4/U6 duplex.
@ast
The first ATPase domain of the ...... unwinding of the U4/U6 duplex.
@en
The first ATPase domain of the ...... unwinding of the U4/U6 duplex.
@nl
P2860
P1433
P1476
The first ATPase domain of the ...... unwinding of the U4/U6 duplex.
@en
P2093
P2860
P304
P356
10.1017/S135583829999012X
P407
P577
1999-07-01T00:00:00Z