Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex.
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ATM-Dependent Phosphorylation of All Three Members of the MRN Complex: From Sensor to AdaptorThe Mre11/Rad50/Nbs1 complex: recent insights into catalytic activities and ATP-driven conformational changesATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signalingEnvisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repairTel1 and Rif2 Regulate MRX Functions in End-Tethering and Repair of DNA Double-Strand BreaksThe Ctf18RFC clamp loader is essential for telomere stability in telomerase-negative and mre11 mutant alleles.ATM alters the otherwise robust chromatin mobility at sites of DNA double-strand breaks (DSBs) in human cells.Interdependence of the rad50 hook and globular domain functionsBridging the gap between in vitro and in vivo: Dose and schedule predictions for the ATR inhibitor AZD6738Functional Analysis of the Bacteriophage T4 Rad50 Homolog (gp46) Coiled-coil DomainProcessing by MRE11 is involved in the sensitivity of subtelomeric regions to DNA double-strand breaks.ATP-dependent DNA binding, unwinding, and resection by the Mre11/Rad50 complexVisualization of local DNA unwinding by Mre11/Rad50/Nbs1 using single-molecule FRET.Disease-associated MRE11 mutants impact ATM/ATR DNA damage signaling by distinct mechanisms.Targeting homologous recombination-mediated DNA repair in cancer.Structural studies of DNA end detection and resection in homologous recombination.ATP puts the brake on DNA double-strand break repair: a new study shows that ATP switches the Mre11-Rad50-Nbs1 repair factor between signaling and processing of DNA ends.Eukaryotic Rad50 functions as a rod-shaped dimer.Structural mechanism of ATP-dependent DNA binding and DNA end bridging by eukaryotic Rad50.Rad50 ATPase activity is regulated by DNA ends and requires coordination of both active sites.Post-translational methylations of the archaeal Mre11:Rad50 complex throughout the DNA damage response.Structure of the Rad50 DNA double-strand break repair protein in complex with DNA.Regulation of the DNA Damage Response by DNA-PKcs Inhibitory Phosphorylation of ATM.ATM directs DNA damage responses and proteostasis via genetically separable pathways.Single-Molecule Imaging Reveals How Mre11-Rad50-Nbs1 Initiates DNA Break Repair.Mre11-Rad50-dependent activity of ATM/Tel1 at DNA breaks and telomeres in the absence of Nbs1.Homeodomain Proteins Directly Regulate ATM Kinase ActivityATM in breast and brain tumors: a comprehensive review
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P2860
Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Ataxia telangiectasia-mutated ...... re11/Rad50/Nbs1 (MRN) complex.
@ast
Ataxia telangiectasia-mutated ...... re11/Rad50/Nbs1 (MRN) complex.
@en
type
label
Ataxia telangiectasia-mutated ...... re11/Rad50/Nbs1 (MRN) complex.
@ast
Ataxia telangiectasia-mutated ...... re11/Rad50/Nbs1 (MRN) complex.
@en
prefLabel
Ataxia telangiectasia-mutated ...... re11/Rad50/Nbs1 (MRN) complex.
@ast
Ataxia telangiectasia-mutated ...... re11/Rad50/Nbs1 (MRN) complex.
@en
P2093
P2860
P356
P1476
Ataxia telangiectasia-mutated ...... Mre11/Rad50/Nbs1 (MRN) complex
@en
P2093
Claire Wyman
Eri Kinoshita
Ji-Hoon Lee
Michael R Mand
Soo-Hyun Yang
Tanya T Paull
P2860
P304
12840-12851
P356
10.1074/JBC.M113.460378
P407
P577
2013-03-22T00:00:00Z