Parkin mitochondrial translocation is achieved through a novel catalytic activity coupled mechanism.
about
Ubiquitin is phosphorylated by PINK1 to activate parkinUbiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysisRBR E3 ubiquitin ligases: new structures, new insights, new questionsMitophagy in hematopoietic stem cells: the case for explorationParkin structure and functionPhosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tetheringPhosphorylation by PINK1 releases the UBL domain and initializes the conformational opening of the E3 ubiquitin ligase ParkinActivation of the E3 ubiquitin ligase Parkin.Targeting Pink1-Parkin-mediated mitophagy for treating liver injuryGlutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagyStructural insights into Parkin substrate lysine targeting from minimal Miro substratesPINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activityKeeping the immune system in check: a role for mitophagy.A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differentlyPINK1 triggers autocatalytic activation of Parkin to specify cell fate decisionsQuantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis.Ubiquitination increases parkin activity to promote autophagic α-synuclein clearance.Identification and molecular characterization of Parkin in Clonorchis sinensis.Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy.Deubiquitinating enzymes regulate PARK2-mediated mitophagy.Structural and Functional Impact of Parkinson Disease-Associated Mutations in the E3 Ubiquitin Ligase ParkinThe roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's diseaseThe ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradationMiro phosphorylation sites regulate Parkin recruitment and mitochondrial motility.Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy.PINK1-dependent phosphorylation of PINK1 and Parkin is essential for mitochondrial quality control.Organellophagy: eliminating cellular building blocks via selective autophagy.Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity.Nilotinib-induced autophagic changes increase endogenous parkin level and ubiquitination, leading to amyloid clearancePhospho-ubiquitin: upending the PINK-Parkin-ubiquitin cascadeSpecificity and disease in the ubiquitin systemParkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.Dysregulation of Parkin-mediated mitophagy in thyroid Hürthle cell tumors.Phosphorylated ubiquitin chain is the genuine Parkin receptor.NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease.Parkin-catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation.How phosphoubiquitin activates Parkin.Lysine 63-linked polyubiquitination is dispensable for Parkin-mediated mitophagy.Mechanism of phospho-ubiquitin-induced PARKIN activation.Molecular insights into RBR E3 ligase ubiquitin transfer mechanisms.
P2860
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P2860
Parkin mitochondrial translocation is achieved through a novel catalytic activity coupled mechanism.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Parkin mitochondrial transloca ...... ic activity coupled mechanism.
@en
type
label
Parkin mitochondrial transloca ...... ic activity coupled mechanism.
@en
prefLabel
Parkin mitochondrial transloca ...... ic activity coupled mechanism.
@en
P2860
P356
P1433
P1476
Parkin mitochondrial transloca ...... ic activity coupled mechanism.
@en
P2093
Tony Hunter
Xinde Zheng
P2860
P2888
P304
P356
10.1038/CR.2013.66
P577
2013-05-14T00:00:00Z
P5875
P6179
1019039767