Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39. - Test2 - elhamkhani - TriplyDB

Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39.

Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39.

http://www.wikidata.org/entity/Q46244118

about

Advances in targeted and immunobased therapies for colorectal cancer in the genomic era Ins and outs of GPCR signaling in primary cilia Pharmacology and physiology of gastrointestinal enteroendocrine cells Not so Fast: Co-Requirements for Sonic Hedgehog Induced Brain Tumorigenesis Primary cilium and sonic hedgehog signaling during neural tube patterning: role of GPCRs and second messengers GPR39 marks specific cells within the sebaceous gland and contributes to skin wound healing Synthetic Small Molecule Inhibitors of Hh Signaling As Anti-Cancer Chemotherapeutics.Novel Zn2+ Modulated GPR39 Receptor Agonists Do Not Drive Acute Insulin Secretion in Rodents.An in vivo multiplexed small-molecule screening platform.An essential role for Grk2 in Hedgehog signalling downstream of Smoothened.Recent advances in the design of Hedgehog pathway inhibitors for the treatment of malignancies.Herbal Medicine Offered as an Initiative Therapeutic Option for the Management of Hepatocellular Carcinoma.Solasonine, A Natural Glycoalkaloid Compound, Inhibits Gli-Mediated Transcriptional Activity.Nuclear/cytoplasmic transport defects in BBS6 underlie congenital heart disease through perturbation of a chromatin remodeling protein.Discovery of 2-Pyridylpyrimidines as the First Orally Bioavailable GPR39 Agonists.Discovery of new GPCR ligands to illuminate new biology.Discovery of a Novel Inhibitor of the Hedgehog Signaling Pathway through Cell-based Compound Discovery and Target Prediction.A Photoaffinity Labeling-Based Chemoproteomics Strategy for Unbiased Target Deconvolution of Small Molecule Drug Candidates.Targeting G Protein-Coupled Receptors by Capture Compound Mass Spectrometry: A Case Study with Sertindole.

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P2860

Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39.

http://www.wikidata.org/entity/Q46244118

description

2014 nî lūn-bûn

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2014年の論文

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2014年学术文章

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2014年学术文章

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2014年学术文章

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2014年学术文章

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2014年學術文章

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2014年學術文章

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name

Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39.

@en

Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39.

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type

label

Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39.

@en

Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39.

@nl

prefLabel

Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39.

@en

Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39.

@nl

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Nature Chemical Biology

P1476

Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39.

@en

P2093

Aaron Bourret

http://www.w3.org/2001/XMLSchema#string

Adam Carlson

http://www.w3.org/2001/XMLSchema#string

Arun Ramamurthy

http://www.w3.org/2001/XMLSchema#string

Barbara Wilmeringwetter

http://www.w3.org/2001/XMLSchema#string

Bianka Grosshans

http://www.w3.org/2001/XMLSchema#string

Fred Harbinski

http://www.w3.org/2001/XMLSchema#string

Heinz Ruffner

http://www.w3.org/2001/XMLSchema#string

Jeffrey A Porter

http://www.w3.org/2001/XMLSchema#string

Jennifer A DaSilva

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John A Tallarico

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P2860

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

Activating Smoothened mutations in sporadic basal-cell carcinoma

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

Mechanisms and functions of Hedgehog signalling across the metazoa

Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma

Isolation of Zn2+ as an endogenous agonist of GPR39 from fetal bovine serum

GPR39 signaling is stimulated by zinc ions but not by obestatin

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343-349

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scholarly article

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10.1038/NCHEMBIO.1481

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5

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10

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Jeremy L. Jenkins

Timothy N Showalter

Frédéric Bassilana

Andreas W Sailer

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2014-03-16T00:00:00Z

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24633354

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