Cloning and chromosomal mapping of a gene isolated from thymic stromal cells encoding a new mouse type II membrane serine protease, epithin, containing four LDL receptor modules and two CUB domains
about
Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substratesMatriptase and HAI-1 are expressed by normal and malignant epithelial cells in vitro and in vivoCatalytic domain structures of MT-SP1/matriptase, a matrix-degrading transmembrane serine proteinaseType II transmembrane serine proteases. Insights into an emerging class of cell surface proteolytic enzymesActivation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine proteaseThe activation of matriptase requires its noncatalytic domains, serine protease domain, and its cognate inhibitorSphingosine 1-phosphate, present in serum-derived lipoproteins, activates matriptaseInhibition of tumor invasion by genomic down-regulation of matriptase through suppression of activation of receptor-bound pro-urokinaseAssembly of adherens junctions is required for sphingosine 1-phosphate-induced matriptase accumulation and activation at mammary epithelial cell-cell contactsN-terminal processing is essential for release of epithin, a mouse type II membrane serine proteaseCloning and characterization of a transmembrane-type serine protease from rat kidney, a new sodium channel activatorSerase-1B, a new splice variant of polyserase-1/TMPRSS9, activates urokinase-type plasminogen activator and the proteolytic activation is negatively regulated by glycosaminoglycansMouse matriptase-2: identification, characterization and comparative mRNA expression analysis with mouse hepsin in adult and embryonic tissuesRegulation of the activity of matriptase on epithelial cell surfaces by a blood-derived factor.The ratio of Matriptase/HAI-1 mRNA is higher in colorectal cancer adenomas and carcinomas than corresponding tissue from control individuals.Matriptase activation, an early cellular response to acidosis.Matriptase zymogen supports epithelial development, homeostasis and regenerationDeregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation.Targeting zymogen activation to control the matriptase-prostasin proteolytic cascade.The protease inhibitor HAI-2, but not HAI-1, regulates matriptase activation and shedding through prostasin.Proteolytic cleavage of human acid-sensing ion channel 1 by the serine protease matriptaseMatriptase is involved in ErbB-2-induced prostate cancer cell invasionFilamin is essential for shedding of the transmembrane serine protease, epithin.Endogenous expression of matriptase in neural progenitor cells promotes cell migration and neuron differentiation.Matriptase: potent proteolysis on the cell surface.Suppression of Tumorigenicity-14, encoding matriptase, is a critical suppressor of colitis and colitis-associated colon carcinogenesisRecombinant CUB-1 domain polypeptide inhibits the cleavage of ULVWF strings by ADAMTS13 under flow conditions.Platelet-derived growth factor-C (PDGF-C) activation by serine proteases: implications for breast cancer progressionNatural Endogenous Human Matriptase and Prostasin Undergo Zymogen Activation via Independent Mechanisms in an Uncoupled Manner.Loss of proteolytically processed filaggrin caused by epidermal deletion of Matriptase/MT-SP1.Synergistic activation of ENaC by three membrane-bound channel-activating serine proteases (mCAP1, mCAP2, and mCAP3) and serum- and glucocorticoid-regulated kinase (Sgk1) in Xenopus OocytesTransmembrane serine protease TADG-15 (ST14/Matriptase/MT-SP1): expression and prognostic value in ovarian cancer.Prostasin expression is regulated by airway surface liquid volume and is increased in cystic fibrosis.Purification from human milk of matriptase complexes with secreted serpins: mechanism for inhibition of matriptase other than HAI-1.A matriptase-prostasin reciprocal zymogen activation complex with unique features: prostasin as a non-enzymatic co-factor for matriptase activation.Membrane-anchored serine proteases in health and disease.Matriptase: a culprit in cancer?Impact of suppression of tumorigenicity 14 (ST14)/serine protease 14 (Prss14) expression analysis on the prognosis and management of estrogen receptor negative breast cancer.Overexpression of matriptase correlates with poor prognosis in esophageal squamous cell carcinoma.Cleavage of hepatocyte growth factor activator inhibitor-1 by membrane-type MMP-1 activates matriptase.
P2860
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P2860
Cloning and chromosomal mapping of a gene isolated from thymic stromal cells encoding a new mouse type II membrane serine protease, epithin, containing four LDL receptor modules and two CUB domains
description
1999 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1999
@ast
im Mai 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1999/05/01)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/05/01)
@nl
наукова стаття, опублікована в травні 1999
@uk
مقالة علمية (نشرت في مايو 1999)
@ar
name
Cloning and chromosomal mappin ...... or modules and two CUB domains
@ast
Cloning and chromosomal mappin ...... or modules and two CUB domains
@en
Cloning and chromosomal mappin ...... or modules and two CUB domains
@nl
type
label
Cloning and chromosomal mappin ...... or modules and two CUB domains
@ast
Cloning and chromosomal mappin ...... or modules and two CUB domains
@en
Cloning and chromosomal mappin ...... or modules and two CUB domains
@nl
prefLabel
Cloning and chromosomal mappin ...... or modules and two CUB domains
@ast
Cloning and chromosomal mappin ...... or modules and two CUB domains
@en
Cloning and chromosomal mappin ...... or modules and two CUB domains
@nl
P2093
P3181
P356
P1433
P1476
Cloning and chromosomal mappin ...... or modules and two CUB domains
@en
P2093
R. H. Schwartz
P2888
P304
P3181
P356
10.1007/S002510050515
P407
P577
1999-05-01T00:00:00Z
P5875
P6179
1048959733