The kinetic basis of peptide exchange catalysis by HLA-DM
about
Small molecules that enhance the catalytic efficiency of HLA-DMA step-by-step overview of the dynamic process of epitope selection by major histocompatibility complex class II for presentation to helper T cellsAn MHC class II restriction bias in CD4 T cell responses toward I-A is altered to I-E in DM-deficient miceEx vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramersHLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanismConformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchangeDisruption of Hydrogen Bonds between Major Histocompatibility Complex Class II and the Peptide N-Terminus Is Not Sufficient to Form a Human Leukocyte Antigen-DM Receptive State of Major Histocompatibility Complex Class IIAchieving stability through editing and chaperoning: regulation of MHC class II peptide binding and expressionModel for the peptide-free conformation of class II MHC proteins.HLA-DM mediates epitope selection by a "compare-exchange" mechanism when a potential peptide pool is available.Cutting edge: HLA-DM functions through a mechanism that does not require specific conserved hydrogen bonds in class II MHC-peptide complexes.The melting pot of the MHC II peptidomeThe convergent roles of tapasin and HLA-DM in antigen presentation.Evaluating the Role of HLA-DM in MHC Class II-Peptide Association Reactions.The Thermodynamic Mechanism of Peptide-MHC Class II Complex Formation Is a Determinant of Susceptibility to HLA-DM.The utility and limitations of current Web-available algorithms to predict peptides recognized by CD4 T cells in response to pathogen infectionResolving multiple protein-peptide binding events: implication for HLA-DQ2 mediated antigen presentation in celiac disease.Empty class II major histocompatibility complex created by peptide photolysis establishes the role of DM in peptide association.The impact of DM on MHC class II-restricted antigen presentation can be altered by manipulation of MHC-peptide kinetic stabilityThe optimization of peptide cargo bound to MHC class I molecules by the peptide-loading complex.Right place, right time, right peptide: DO keeps DM focused.Conformational isomers of a peptide-class II major histocompatibility complex.The control of the specificity of CD4 T cell responses: thresholds, breakpoints, and ceilingsHLA-DM mediates peptide exchange by interacting transiently and repeatedly with HLA-DR1.Conformational heterogeneity of MHC class II induced upon binding to different peptides is a key regulator in antigen presentation and epitope selection.Conformational variation in structures of classical and non-classical MHCII proteins and functional implications.Measurement of Peptide Binding to MHC Class II Molecules by Fluorescence Polarization.Structural Insights Into HLA-DM Mediated MHC II Peptide Exchange.A novel method to measure HLA-DM-susceptibility of peptides bound to MHC class II molecules based on peptide binding competition assay and differential IC(50) determination.Identification of the lateral interaction surfaces of human histocompatibility leukocyte antigen (HLA)-DM with HLA-DR1 by formation of tethered complexes that present enhanced HLA-DM catalysisMonoclonal antibodies specific for the empty conformation of HLA-DR1 reveal aspects of the conformational change associated with peptide binding.Antibody specific for the peptide.major histocompatibility complex. Is it T cell receptor-like?"Chemical analogues" of HLA-DM can induce a peptide-receptive state in HLA-DR molecules.Studying MHC class II peptide loading and editing in vitro.
P2860
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P2860
The kinetic basis of peptide exchange catalysis by HLA-DM
description
2001 nî lūn-bûn
@nan
2001 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
The kinetic basis of peptide exchange catalysis by HLA-DM
@ast
The kinetic basis of peptide exchange catalysis by HLA-DM
@en
type
label
The kinetic basis of peptide exchange catalysis by HLA-DM
@ast
The kinetic basis of peptide exchange catalysis by HLA-DM
@en
prefLabel
The kinetic basis of peptide exchange catalysis by HLA-DM
@ast
The kinetic basis of peptide exchange catalysis by HLA-DM
@en
P2093
P2860
P356
P1476
The kinetic basis of peptide exchange catalysis by HLA-DM
@en
P2093
E D Mellins
J A Zarutskie
Z Zavala-Ruiz
P2860
P304
12450-12455
P356
10.1073/PNAS.211439398
P407
P577
2001-10-16T00:00:00Z