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The kinetic basis of peptide exchange catalysis by HLA-DM

The kinetic basis of peptide exchange catalysis by HLA-DM

http://www.wikidata.org/entity/Q33947777

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Small molecules that enhance the catalytic efficiency of HLA-DM A step-by-step overview of the dynamic process of epitope selection by major histocompatibility complex class II for presentation to helper T cells An MHC class II restriction bias in CD4 T cell responses toward I-A is altered to I-E in DM-deficient mice Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange Disruption of Hydrogen Bonds between Major Histocompatibility Complex Class II and the Peptide N-Terminus Is Not Sufficient to Form a Human Leukocyte Antigen-DM Receptive State of Major Histocompatibility Complex Class II Achieving stability through editing and chaperoning: regulation of MHC class II peptide binding and expression Model for the peptide-free conformation of class II MHC proteins.HLA-DM mediates epitope selection by a "compare-exchange" mechanism when a potential peptide pool is available.Cutting edge: HLA-DM functions through a mechanism that does not require specific conserved hydrogen bonds in class II MHC-peptide complexes.The melting pot of the MHC II peptidome The convergent roles of tapasin and HLA-DM in antigen presentation.Evaluating the Role of HLA-DM in MHC Class II-Peptide Association Reactions.The Thermodynamic Mechanism of Peptide-MHC Class II Complex Formation Is a Determinant of Susceptibility to HLA-DM.The utility and limitations of current Web-available algorithms to predict peptides recognized by CD4 T cells in response to pathogen infection Resolving multiple protein-peptide binding events: implication for HLA-DQ2 mediated antigen presentation in celiac disease.Empty class II major histocompatibility complex created by peptide photolysis establishes the role of DM in peptide association.The impact of DM on MHC class II-restricted antigen presentation can be altered by manipulation of MHC-peptide kinetic stability The optimization of peptide cargo bound to MHC class I molecules by the peptide-loading complex.Right place, right time, right peptide: DO keeps DM focused.Conformational isomers of a peptide-class II major histocompatibility complex.The control of the specificity of CD4 T cell responses: thresholds, breakpoints, and ceilings HLA-DM mediates peptide exchange by interacting transiently and repeatedly with HLA-DR1.Conformational heterogeneity of MHC class II induced upon binding to different peptides is a key regulator in antigen presentation and epitope selection.Conformational variation in structures of classical and non-classical MHCII proteins and functional implications.Measurement of Peptide Binding to MHC Class II Molecules by Fluorescence Polarization.Structural Insights Into HLA-DM Mediated MHC II Peptide Exchange.A novel method to measure HLA-DM-susceptibility of peptides bound to MHC class II molecules based on peptide binding competition assay and differential IC(50) determination.Identification of the lateral interaction surfaces of human histocompatibility leukocyte antigen (HLA)-DM with HLA-DR1 by formation of tethered complexes that present enhanced HLA-DM catalysis Monoclonal antibodies specific for the empty conformation of HLA-DR1 reveal aspects of the conformational change associated with peptide binding.Antibody specific for the peptide.major histocompatibility complex. Is it T cell receptor-like?"Chemical analogues" of HLA-DM can induce a peptide-receptive state in HLA-DR molecules.Studying MHC class II peptide loading and editing in vitro.

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P2860

The kinetic basis of peptide exchange catalysis by HLA-DM

http://www.wikidata.org/entity/Q33947777

description

2001 nî lūn-bûn

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2001 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2001 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年论文

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name

The kinetic basis of peptide exchange catalysis by HLA-DM

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The kinetic basis of peptide exchange catalysis by HLA-DM

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The kinetic basis of peptide exchange catalysis by HLA-DM

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The kinetic basis of peptide exchange catalysis by HLA-DM

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The kinetic basis of peptide exchange catalysis by HLA-DM

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The kinetic basis of peptide exchange catalysis by HLA-DM

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Proceedings of the National Academy of Sciences of the United States of America

P1476

The kinetic basis of peptide exchange catalysis by HLA-DM

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P2093

E D Mellins

http://www.w3.org/2001/XMLSchema#string

J A Zarutskie

http://www.w3.org/2001/XMLSchema#string

L J Stern

http://www.w3.org/2001/XMLSchema#string

M Rushe

http://www.w3.org/2001/XMLSchema#string

R Busch

http://www.w3.org/2001/XMLSchema#string

Z Zavala-Ruiz

http://www.w3.org/2001/XMLSchema#string

P2860

HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides

An essential role for HLA-DM in antigen presentation by class II major histocompatibility molecules

The structure of HLA-DM, the peptide exchange catalyst that loads antigen onto class II MHC molecules during antigen presentation

Crystal structure of mouse H2-M

HLA-DMA and -DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells

Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM

Editing of the HLA-DR-peptide repertoire by HLA-DM

HLA-DM acts as a molecular chaperone and rescues empty HLA-DR molecules at lysosomal pH

Determination of the HLA-DM interaction site on HLA-DR molecules.

Conformational isomers of a class II MHC-peptide complex in solution.

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12450-12455

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10.1073/PNAS.211439398

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22

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98

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11606721

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60074

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