Intermediates in V(D)J recombination: a stable RAG1/2 complex sequesters cleaved RSS ends.
about
Distinct requirements for Ku in N nucleotide addition at V(D)J- and non-V(D)J-generated double-strand breaksXRCC4's interaction with XLF is required for coding (but not signal) end joiningThe response to and repair of RAG-mediated DNA double-strand breaksPutting the pieces together: identification and characterization of structural domains in the V(D)J recombination protein RAG1The taming of a transposon: V(D)J recombination and the immune systemAutoubiquitylation of the V(D)J recombinase protein RAG1A hypomorphic recombination-activating gene 1 (RAG1) mutation resulting in a phenotype resembling common variable immunodeficiency.Crystal structure of the V(D)J recombinase RAG1-RAG2RAG2's acidic hinge restricts repair-pathway choice and promotes genomic stability.Requirement for ubiquitin conjugation and 26S proteasome activity at an early stage in V(D)J recombinationNon-consensus heptamer sequences destabilize the RAG post-cleavage complex, making ends available to alternative DNA repair pathways.Effect of HIV integrase inhibitors on the RAG1/2 recombinase.Ordered assembly of the V(D)J synaptic complex ensures accurate recombinationA RAG-1/RAG-2 tetramer supports 12/23-regulated synapsis, cleavage, and transposition of V(D)J recombination signals.Mobilization of RAG-generated signal ends by transposition and insertion in vivoAtaxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation.In vivo transposition mediated by V(D)J recombinase in human T lymphocytes.The C-terminal portion of RAG2 protects against transposition in vitroDynamic mechanism of nick recognition by DNA ligase.Unique and redundant functions of ATM and DNA-PKcs during V(D)J recombinationV(D)J recombination in zebrafish: Normal joining products with accumulation of unresolved coding ends and deleted signal ends.The bounty of RAGs: recombination signal complexes and reaction outcomes.Artemis sheds new light on V(D)J recombination.V(D)J recombination: how to tame a transposase.New concepts in the regulation of an ancient reaction: transposition by RAG1/RAG2.Assembly Pathway and Characterization of the RAG1/2-DNA Paired and Signal-end Complexesvon Hippel Lindau binding protein 1-mediated degradation of integrase affects HIV-1 gene expression at a postintegration step.Real-time monitoring of RAG-catalyzed DNA cleavage unveils dynamic changes in coding end association with the coding end complex.Evidence for Ku70/Ku80 association with full-length RAG1.Restoration of ATM Expression in DNA-PKcs-Deficient Cells Inhibits Signal End Joining.Lymphocyte development: integration of DNA damage response signaling.Leaky severe combined immunodeficiency and aberrant DNA rearrangements due to a hypomorphic RAG1 mutation.Accessibility of chromosomal recombination breaks in nuclei of wild-type and DNA-PKcs-deficient cells.Initial stages of V(D)J recombination: the organization of RAG1/2 and RSS DNA in the postcleavage complex.Functional overlaps between XLF and the ATM-dependent DNA double strand break response.The structure-specific nicking of small heteroduplexes by the RAG complex: implications for lymphoid chromosomal translocations.Replication independent DNA double-strand break retention may prevent genomic instabilityModeling of the RAG reaction mechanism.The ATM Kinase Restrains Joining of Both VDJ Signal and Coding Ends.Repair of chromosomal RAG-mediated DNA breaks by mutant RAG proteins lacking phosphatidylinositol 3-like kinase consensus phosphorylation sites.
P2860
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P2860
Intermediates in V(D)J recombination: a stable RAG1/2 complex sequesters cleaved RSS ends.
description
2001 nî lūn-bûn
@nan
2001 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Intermediates in V(D)J recombi ...... x sequesters cleaved RSS ends.
@ast
Intermediates in V(D)J recombi ...... x sequesters cleaved RSS ends.
@en
type
label
Intermediates in V(D)J recombi ...... x sequesters cleaved RSS ends.
@ast
Intermediates in V(D)J recombi ...... x sequesters cleaved RSS ends.
@en
prefLabel
Intermediates in V(D)J recombi ...... x sequesters cleaved RSS ends.
@ast
Intermediates in V(D)J recombi ...... x sequesters cleaved RSS ends.
@en
P2860
P356
P1476
Intermediates in V(D)J recombi ...... x sequesters cleaved RSS ends.
@en
P2093
P2860
P304
12926-12931
P356
10.1073/PNAS.221471198
P407
P577
2001-10-23T00:00:00Z