The C-terminal portion of RAG2 protects against transposition in vitro - Wikidata - wikimedia - TriplyDB

The C-terminal portion of RAG2 protects against transposition in vitro

The C-terminal portion of RAG2 protects against transposition in vitro

http://www.wikidata.org/entity/Q34985848

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Lack of MSH2 involvement differentiates V(D)J recombination from other non-homologous end joining events RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination Putting the pieces together: identification and characterization of structural domains in the V(D)J recombination protein RAG1 Recombination-activating gene proteins: more regulation, please The taming of a transposon: V(D)J recombination and the immune system Autoubiquitylation of the V(D)J recombinase protein RAG1 A PHD finger motif in the C terminus of RAG2 modulates recombination activity Target DNA structure plays a critical role in RAG transposition.In vivo reinsertion of excised episomes by the V(D)J recombinase: a potential threat to genomic stability.Guanosine triphosphate acts as a cofactor to promote assembly of initial P-element transposase-DNA synaptic complexes.Mobilization of RAG-generated signal ends by transposition and insertion in vivo Autoinhibition of DNA cleavage mediated by RAG1 and RAG2 is overcome by an epigenetic signal in V(D)J recombination Regulation of RAG1/RAG2-mediated transposition by GTP and the C-terminal region of RAG2 Requirements for DNA hairpin formation by RAG1/2 DNA cleavage activity of the V(D)J recombination protein RAG1 is autoregulated.The bounty of RAGs: recombination signal complexes and reaction outcomes.V(D)J recombination: how to tame a transposase.New concepts in the regulation of an ancient reaction: transposition by RAG1/RAG2.Real-time monitoring of RAG-catalyzed DNA cleavage unveils dynamic changes in coding end association with the coding end complex.Chromosomal reinsertion of broken RSS ends during T cell development.Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice.Understanding how the V(D)J recombinase catalyzes transesterification: distinctions between DNA cleavage and transposition.RAG: a recombinase diversified.Ordered DNA release and target capture in RAG transposition DNA mismatches and GC-rich motifs target transposition by the RAG1/RAG2 transposase.V(D)J recombination: Born to be wild Full-length RAG-2, and not full-length RAG-1, specifically suppresses RAG-mediated transposition but not hybrid joint formation or disintegration.V(D)J Recombination: Mechanism, Errors, and Fidelity.New insights into the evolutionary origins of the recombination-activating gene proteins and V(D)J recombination.Mechanistic basis for RAG discrimination between recombination sites and the off-target sites of human lymphomas.Increased frequency of aberrant V(D)J recombination products in core RAG-expressing mice.In vitro processing of the 3'-overhanging DNA in the postcleavage complex involved in V(D)J joining.Discovery of an Active RAG Transposon Illuminates the Origins of V(D)J Recombination.Double-strand break formation by the RAG complex at the bcl-2 major breakpoint region and at other non-B DNA structures in vitro.RAG1/2 induces genomic insertions by mobilizing DNA into RAG1/2-independent breaks Cell cycle-dependent accumulation in vivo of transposition-competent complexes between recombination signal ends and full-length RAG proteins.ATP-dependent remodeling by SWI/SNF and ISWI proteins stimulates V(D)J cleavage of 5 S arrays.Evolution of RAG transposon unveiled.

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P2860

The C-terminal portion of RAG2 protects against transposition in vitro

http://www.wikidata.org/entity/Q34985848

description

2003 nî lūn-bûn

@nan

2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2003年の論文

@ja

2003年論文

@yue

2003年論文

@zh-hant

2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

@zh-tw

2003年论文

@wuu

name

The C-terminal portion of RAG2 protects against transposition in vitro

@ast

The C-terminal portion of RAG2 protects against transposition in vitro

@en

The C-terminal portion of RAG2 protects against transposition in vitro

@nl

type

label

The C-terminal portion of RAG2 protects against transposition in vitro

@ast

The C-terminal portion of RAG2 protects against transposition in vitro

@en

The C-terminal portion of RAG2 protects against transposition in vitro

@nl

prefLabel

The C-terminal portion of RAG2 protects against transposition in vitro

@ast

The C-terminal portion of RAG2 protects against transposition in vitro

@en

The C-terminal portion of RAG2 protects against transposition in vitro

@nl

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P1433

The EMBO Journal

P1476

The C-terminal portion of RAG2 protects against transposition in vitro

@en

P2093

Adam G Matthews

http://www.w3.org/2001/XMLSchema#string

Marjorie A Oettinger

http://www.w3.org/2001/XMLSchema#string

Sheryl K Elkin

http://www.w3.org/2001/XMLSchema#string

P2860

The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination

Expression and V(D)J recombination activity of mutated RAG-1 proteins

Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase

Evolution of antigen binding receptors.

Functional analysis of coordinated cleavage in V(D)J recombination.

Dual role of RAG2 in V(D)J recombination: catalysis and regulation of ordered Ig gene assembly.

Intermediates in V(D)J recombination: a stable RAG1/2 complex sequesters cleaved RSS ends.

RAG transposase can capture and commit to target DNA before or after donor cleavage

Assembly of the RAG1/RAG2 synaptic complex

Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice

P304

1931-1938

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1093/EMBOJ/CDG184

http://www.w3.org/2001/XMLSchema#string

P407

P433

8

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P478

22

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P577

2003-04-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

10816484

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P698

12682025

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P932

154476

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