NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation. - Wikidata - wikimedia - TriplyDB

NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation.

NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation.

http://www.wikidata.org/entity/Q34479707

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The spectrum of disease in chronic traumatic encephalopathy Is tau ready for admission to the prion club?Cytosolic prostaglandin E synthase: expression patterns in control and Alzheimer's disease brains Dysfunction of NMDA receptors in Alzheimer's disease Neuroimaging assessment of early and late neurobiological sequelae of traumatic brain injury: implications for CTE Tangles, Toxicity, and Tau Secretion in AD - New Approaches to a Vexing Problem Serine racemase: a key player in apoptosis and necrosis Early mechanisms of pathobiology are revealed by transcriptional temporal dynamics in hippocampal CA1 neurons of prion infected mice The dendritic hypothesis for Alzheimer's disease pathophysiology.Calpastatin modulates APP processing in the brains of β-amyloid depositing but not wild-type mice The amino terminus of tau inhibits kinesin-dependent axonal transport: implications for filament toxicity.Pharmacodynamics of memantine: an update.Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression.Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture.Postsynaptic density-95 (PSD-95) and calcineurin control the sensitivity of N-methyl-D-aspartate receptors to calpain cleavage in cortical neurons.Implicating calpain in tau-mediated toxicity in vivo.Alzheimer's proteins, oxidative stress, and mitochondrial dysfunction interplay in a neuronal model of Alzheimer's disease.Organization, control and function of extrasynaptic NMDA receptors.Tau phosphorylation and μ-calpain activation mediate the dexamethasone-induced inhibition on the insulin-stimulated Akt phosphorylation.Lysine methylation is an endogenous post-translational modification of tau protein in human brain and a modulator of aggregation propensity.Amyloid beta-mediated cell death of cultured hippocampal neurons reveals extensive Tau fragmentation without increased full-length tau phosphorylation.The role of the tripartite glutamatergic synapse in the pathophysiology of Alzheimer's disease.Calpain dysregulation in Alzheimer's disease Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation.Curcumin Improves Amyloid β-Peptide (1-42) Induced Spatial Memory Deficits through BDNF-ERK Signaling Pathway.Comparison of the neuropsychological mechanisms of 2,6-diisopropylphenol and N-methyl-D-aspartate receptor antagonist against electroconvulsive therapy-induced learning and memory impairment in depressed rats.The neuropathology of chronic traumatic encephalopathy.Caspase-3- and calpain-mediated tau cleavage are differentially prevented by estrogen and testosterone in beta-amyloid-treated hippocampal neurons.Neurotransmitter receptors and cognitive dysfunction in Alzheimer's disease and Parkinson's disease.Supplementation of Convolvulus pluricaulis attenuates scopolamine-induced increased tau and amyloid precursor protein (AβPP) expression in rat brain.Location, location, location: altered transcription factor trafficking in neurodegeneration.Glutamate system, amyloid ß peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathology Co-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomes A brief review of the pharmacologic and therapeutic aspects of memantine in Alzheimer's disease.Interferon gamma induces protective non-canonical signaling pathways in primary neurons The Tau/A152T mutation, a risk factor for frontotemporal-spectrum disorders, leads to NR2B receptor-mediated excitotoxicity.NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss.Accumulation of human full-length tau induces degradation of nicotinic acetylcholine receptor α4 via activating calpain-2.The role of tau in neurodegeneration Calpain-mediated signaling mechanisms in neuronal injury and neurodegeneration

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P2860

NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation.

http://www.wikidata.org/entity/Q34479707

description

2006 nî lūn-bûn

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2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2006 թվականի փետրվարին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation.

@ast

NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation.

@en

NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation.

@nl

type

label

NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation.

@ast

NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation.

@en

NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation.

@nl

prefLabel

NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation.

@ast

NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation.

@en

NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation.

@nl

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Proceedings of the National Academy of Sciences of the United States of America

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NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation

@en

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Marco Costanzi

http://www.w3.org/2001/XMLSchema#string

Maria Teresa Ciotti

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Nadia Canu

http://www.w3.org/2001/XMLSchema#string

Pietro Calissano

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Vincenzo Cestari

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P2860

Tau cleavage and dephosphorylation in cerebellar granule neurons undergoing apoptosis

The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1.

Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death

Regulation of NMDA receptor trafficking by amyloid-beta

Tau suppression in a neurodegenerative mouse model improves memory function

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy.

Proapoptotic effects of tau cleavage product generated by caspase-3.

Multiple forms of Ca-activated protease from rat brain and muscle.

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2892-2897

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10.1073/PNAS.0511065103

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103

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Giuseppina Amadoro

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7300014

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16477009

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1413822

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