Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structures - Wikidata - wikimedia - TriplyDB

Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structures

Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structures

http://www.wikidata.org/entity/Q34649104

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Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint Claspin promotes normal replication fork rates in human cells The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways Roles of Chk1 in cell biology and cancer therapy Importance of a C-terminal conserved region of Chk1 for checkpoint function.Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress.Drf1-dependent kinase interacts with Claspin through a conserved protein motif.Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair Direct Binding to Replication Protein A (RPA)-coated Single-stranded DNA Allows Recruitment of the ATR Activator TopBP1 to Sites of DNA Damage.Properties of internalization factors contributing to the uptake of extracellular DNA into tumor-initiating stem cells of mouse Krebs-2 cell line.APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress.The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM Estrogen inhibits ATR signaling to cell cycle checkpoints and DNA repair.Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways.The direct binding of Mrc1, a checkpoint mediator, to Mcm6, a replication helicase, is essential for the replication checkpoint against methyl methanesulfonate-induced stress.Reconstitution of human claspin-mediated phosphorylation of Chk1 by the ATR (ataxia telangiectasia-mutated and rad3-related) checkpoint kinase.Multiple functions of the S-phase checkpoint mediator.Mrc1/Claspin: a new role for regulation of origin firing.Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells ATR signaling at a glance.Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM.Phosphatase Type 2A-dependent and -independent Pathways for ATR Phosphorylation of Chk1

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P2860

Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structures

http://www.wikidata.org/entity/Q34649104

description

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2006 թվականի մարտին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Site-specific phosphorylation ...... es to different DNA structures

@ast

Site-specific phosphorylation ...... es to different DNA structures

@en

Site-specific phosphorylation ...... es to different DNA structures

@nl

type

label

Site-specific phosphorylation ...... es to different DNA structures

@ast

Site-specific phosphorylation ...... es to different DNA structures

@en

Site-specific phosphorylation ...... es to different DNA structures

@nl

prefLabel

Site-specific phosphorylation ...... es to different DNA structures

@ast

Site-specific phosphorylation ...... es to different DNA structures

@en

Site-specific phosphorylation ...... es to different DNA structures

@nl

P1433

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P2860

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P356

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Genes & Development

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Site-specific phosphorylation ...... es to different DNA structures

@en

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Hae Yong Yoo

http://www.w3.org/2001/XMLSchema#string

Seong-Yun Jeong

http://www.w3.org/2001/XMLSchema#string

William G Dunphy

http://www.w3.org/2001/XMLSchema#string

P2860

BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

Geminin, an inhibitor of DNA replication, is degraded during mitosis

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex.

An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication

Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1

Human claspin is required for replication checkpoint control

P304

772-783

http://www.w3.org/2001/XMLSchema#string

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scholarly article

P356

10.1101/GAD.1398806

http://www.w3.org/2001/XMLSchema#string

P433

7

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20

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2006-03-17T00:00:00Z

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7232092

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16547171

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phosphorylation

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1472281

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